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    The Relationship of Cognitive Performance with Oxidative Stress in Alzheimer's Disease
    (Taiwan Soc Geriatric Emergency & Critical Care Medicine-Tsgecm, 2022) Yakaryilmaz, Funda Datli; Ozturk, Zeynel Abidin; Ulusal, Hasan; Tarakicoglu, Mehmet
    Aims: Alzheimer's disease (AD) has a complex neurodegenerative etiology and pathogenesis. In addition to oxidative stress, inflammation also plays an important role in the development of AD. In this study, we aimed to determine the total antioxidant status (TAS), total oxidation status (TOS) and oxidative stress index (OSI) levels in AD patients. We also planned to evaluate the relationship of OSI with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha). Methods: A total of 33 subjects with AD (mean age 78.9 +/- 7.8) and 33 subjects as control (mean age 72.3 +/- 2.6) were enrolled in this cross-sectional study. TAS and TOS were assessed with commercial kits using an autoanalyzer. TNF-alpha and IL-1 beta were measured with commercial ELISA kits. Results: The AD group demonstrated significantly higher TNF-alpha, IL-1 beta, and TOS levels compared to the control group (p = 0.001, p = 0.029, p = 0.005). The mean TAS level was significantly lower in the AD group than in the control group (p = 0.007). There was a statistically significant negative correlation between TNF-alpha and ADL, IADL, MMSE (p = 0.001, p =0.003, p = 0.003). There was a statistically significant negative correlation between IL-1 beta and AIDL, as well as a positive correlation between IL-1 beta and GDS (p = 0.029, p = 0.016). Conclusion: Our study contributes to the understanding of the situation by showing that the oxidative balance is impaired in favor of oxidants in AD. A negative correlation was found between functional capacity and TNF-alpha and IL-1 beta levels in AD patients. Different therapeutic interventions that reduce the oxidant load can be considered in the treatment of AD. Copyright (C) 2022, Taiwan Society of Geriatric Emergency & Critical Care Medicine.
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    Salivary cortisol and total antioxidant capacity levels of children with untreated dental caries
    (2020) Keskin, Gul; Ucar Gundogar, Zubeyde; Ozdogru, Hakan; Ulusal, Hasan; Gundogar, Hasan
    Aim: The study aimed to evaluate the relationship between the caries frequency, which was determined using different caries indexes and biological parameters such as salivary cortisol and total antioxidant capacity (TAC).Materials and Methods: 140 patients between the ages of 5-13 without systemic disease were included in the study. Saliva samples were collected from patients whose DMFT (dmft) and PUFA (pufa) indexes were recorded, and these samples were centrifuged at 5,000 rpm for 10 minutes. All samples were stored at -20 °C until measurement. Saliva cortisol and TAC levels were measured using the ELISA kit. All data were analyzed with SPSS v.22.Results: The mean DMFT/dmft and PUFA/pufa values were estimated as 6.72±4.37, 1.39±2.08, respectively. There was no significant correlation between caries indexes and biochemical parameters.However, there was a correlation between TAC and cortisol levels in saliva. Conclusion: Within the limitations of this study, it was determined that high risk of caries in patients could not affect salivary cortisol and TAC levels; however, there was a positive correlation between salivary cortisol and TAC levels. Further studies are needed to better understand the background of the pathophysiological changes in these biochemical parameters and their relationship with caries.