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    Antioxidant Effect of a Dihydropyridine Calcium Antagonist Nitrendipine in Streptozotocin-Induced Diabetes
    (Pleiades Publishing Inc, 2020) Unuvar, S.; Gursoy, S.; Berk, A.; Kaymaz, B.; Ilhan, N.; Aktay, G.
    The present study aims to evaluate the effects of a dihydropyridine (DHP) derivative calcium channel antagonist nitrendipine (NIT) on lipid peroxidation (LPO), liver enzyme markers, glucose and lipid profile in rats with streptozotocin (STZ)-induced diabetes. A total of 24 female Sprague Dawley rats were classified into three groups as controls, STZ and STZ+NIT. Fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC) and high-density lipoprotein (HDL) levels, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity were measured seven weeks after the administration of STZ and NIT. The levels of thiobarbituric acid substance (TBARS), glutathione (GSH) and total thiol content (T-SH), as well as the levels of nitric oxide and metabolites (NO, nitrate, nitrite), were evaluated to assess the level of lipid peroxidation in liver, brain, kidney, heart and eye tissues. STZ significantly increased FBG levels, ALT and AST activity, and TBARS levels (p < 0.001, for all), and significantly reduced the levels of GSH and T-SH (p < 0.05), as well as total NO and nitrate (p < 0.001). STZ triggered LPO in tissues, while simultaneously causing a marked decrease in endogenous antioxidant content. NIT administration protect the kidney (p < 0.05), heart (p < 0.01), brain (p < 0.001) and eye (p < 0.05) tissues from LPO, and also normalized the elevated FBG levels and the activity of ALT and AST (p < 0.001, for all). NIT further stimulated GSH and T-SH production, particularly in the liver, kidney and heart tissues. The results of the present study suggest that NIT shows hypoglycemic activity in STZ-DM rats by increasing insulin sensitivity in the peripheral target tissues.
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    Antioxidant Effect of a Dihydropyridine Calcium Antagonist Nitrendipine in Streptozotocin-Induced Diabetes (vol 57, pg 126, 2020)
    (Pleiades Publishing Inc, 2021) Unuvar, S.; Gursoy, S.; Berk, A.; Kaymaz, B.; Ilhan, N.; Aktay, G.
    [Abstract Not Available]
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    Apoptotic, Cytotoxic and Antimigratory Activities of Phenolic Compounds
    (Pleiades Publishing Inc, 2022) Yuce, H.; Sahin, Y.; Turkmen, N. Basak; Ozek, D. Askin; Unuvar, S.; Ciftci, O.
    The objective of this study was to evaluate the biological activities of chrysin (CRY), curcumin (CUR), and ellagic acid (EA) by comparing the anti-proliferative, anti-migration effects, and apoptotic gene expressions between the three human cancer cell lines: lung (A549), liver (HEP3B), and breast (MCF-7) compared to normal human fibroblast cell line (L929). Antiproliferative effects of certain phenolic compounds were determined by the MTS assay. Cells were treated with different concentrations of the compounds for two consecutive days. Their effect on cell migration was evaluated using the wound-healing assay. Apoptosis was evaluated by Bax, Bcl-2, Cas-3, Cas-8, Cas-9, Cas-10, CDK 2, CDK4, CDK6, CCNB1, and CCND2 gene expressions. The MTS assay showed that the compounds had antiproliferative effects on A549, HEP3B, and MCF-7 cell lines in a dose- and time-dependent manner. All three compounds also suppressed the migration of the tumor cell lines, significantly increased the levels of apoptotic gene expression, and induced apoptotic cell death. This study shows that chrysin, curcumin, and ellagic acid could be considered promising chemotherapeutic agents in the treatment of lung, liver, and breast cancers.