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Öğe Ceftazidime-Avibactam: A Retrospective Analysis of Multicenter Real-World Data and Factors Affecting Mortality(Doc Design Informatics Co Ltd, 2025) Aktug-Demir, Nazlim; Temocin, Fatih; Ural, Onur; Gulten, Ezgi; Inal, Ayse Seza; Kader, Cigdem; Ersoy, YaseminObjective: Multidrug-resistant Gram-negative bacteria cause difficult-to-treat infections associated with high mortality. Carbapenems are widely used; however, their overuse has led to the emergence of carbapenem-resistant bacteria. This study aimed to evaluate the indications, clinical and microbiological efficacy, and side effects of ceftazidime-avibactam (CAZ-AVI) and to identify factors influencing mortality, based on data from a large multicenter patient cohort in T & uuml;rkiye. Materials and Methods: Patients with carbapenem-resistant but CAZ-AVI-susceptible Gram-negative bacterial infections who received CAZ-AVI treatment were retrospectively reviewed. Results: A total of 1245 patients were included. The most common indication for CAZ-AVI use was hospital-acquired pneumonia (47.8%). Klebsiella pneumoniae was the predominant pathogen (81.3%). CAZ-AVI was used as a monotherapy in 80% of cases. Clinical side effects were observed in 8 (0.64%) patients, while laboratory abnormalities occurred in 73 (5.86%). The 7-day, 14-day, and 28-day all-cause mortality rates were 13.8%, 28.9%, and 45.2%, respectively. Microbiological eradication was achieved in 82.3% of patients. Higher Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores at admission, requirement for continuous renal replacement therapy, mechanical ventilation, and elevated C-reactive protein levels were identified as independent risk factors for mortality. Conclusion: This large multicenter real-world analysis demonstrates that CAZ-AVI is an effective treatment option for severe infections with high mortality, such as those caused by carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa.Öğe Erythema Chronicum Migrans Lezyonu ile Karakterize Üç Lyme Olgusu(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2008) Güler, Selma; Ural, OnurLyme hastalığı ve bu hastalığın bulgusu olan Erythema chronicum migransı literatür bilgileri ışığında tartışmak. Konu: Lyme hastalığı kenelerle taşınan ve Borrellia burgdorferi tarafından oluşturulan, multisistemik bir hastalıktır. Genellikle erythema chronicum migrans (ECM) olarak bilinen anüler lezyon ile başlar. Bu makalede serolojik olarak ELİSA ile doğrulanmış, ECM bulgusu ile karakterize Lyme hastalığı tanısı alan üç hasta sunulmuştur. Sonuç: Kırsal bölgelerde yaşayan, kene ile temas hikayesi ve deri bulguları olan hastalarda ülkemiz şartlarında lyme hastalığı akılda bulundurulmalıdır.Öğe Management of Chronic Hepatitis B Infection: A Consensus Report of the Study Group for Viral Hepatitis of the Turkish Society of Clinical Microbiology and Infectious Diseases-2023 Update (vol 36, pg 1, 2023)(Doc Design Informatics Co Ltd, 2025) Demirturk, Nese; Kose, Adem; Ural, Onur; Asan, Ali; Barut, Sener; Sumer, Sua; Simsek, Funda[No abstract available]
