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    Bacterial colonization in uninfected pilonidal cyst and its role in developing recurrence in postoperative period: Prospective study
    (2019) Ureyen, Orhan; Tekeli, Mehmet Tahsin; Ustuner, Mehmet Akif; Gungor, Hilmi; Bayram, Emine Deniz
    Aim: To determine the bacterial prevalence and its susceptibility to antibiotics, and additionally, to investigate the relationship between bacterial status and recurrence and complications with regard to whether bacteria reproduce in the cyst cavity in uninfected pilonidal cyst. Material and Methods: The cases included in the study were those who applied to our clinic due to pilonidal sinus and surgical operation was decided. Before the operation, culture specimen was taken using a sterile swab stick from the cyst hole. The cyst was excised with a safety margin. The excised material was opened under the guidance of the cyst hole and the cavity was entered and samples of cyst tissue and content were collected for culture-antibiogram. Results: Totally 46 cases were included in our study, Average age was 26 (18-47) years. Limberg flap was performed to 37 (78%) of the cases, and primary repair to 9 (22%) cases. Average follow-up period was 27.1 (sd±7.6) months. Normal bacterial skin flora was determined in 6 (13%) cases and significant bacterial reproduction in 4 (8.6%) cases (Enterococcus faecalis, Streptococcus anginosus, MRSA, Streptococcus dysgalactiae ) in the cyst cavity culture. In tissue culture however, skin bacterial flora was observed in 9 (19.5%) cases, while bacterial growth only in 1 case. Recurrence was determined in 3 (3.6%) cases in total. Bacterial growth, and other factors were not associated with recurrence (p> 0.05) Conclusion: In this study, non-infected pilonidal sinus surgery does not require bacterial culture to prevent recurrence
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    Mean Platelet Volume Is a Poor Prognostic Factor in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma
    (Aves, 2025) Senturk, Mustafa; Ince, Volkan; Ureyen, Orhan; Eyvaz, Kemal; Isik, Burak; Carr, Brian, I; Yilmaz, Sezai
    Background/Aims: Mean platelet volume (MPV) reflects platelet activation. Platelets have an important role in tumor progression and metastasis. In this study, we wanted to investigate the effect of MPV on survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). Materials and Methods: All data of 376 patients who underwent LT and pathologically diagnosed with HCC were analyzed. Bydetermin- ing the cut-off of MPV (10.2 fL), 2 groups with high and low MPV were formed. The groups were compared within themselves. Factors affecting survival were determined by univariate and multivariate analysis. Results: When the groups were compared, patients with low MPV had significantly higher platelet counts, larger tumor sizes, lower BMI, and higher recurrence rates. In multivariate analysis, GGT >104, AFP >200 mu g/L, largest tumor diameter >5 cm, and lower MPV were found to be independent risk factors that affected the prognosis. Tumor-free survival was significantly worse in the lower MPV group (P = .002). Conclusion: Pre-transplant low MPV maybe useful in predicting poor prognosis and a high rate of tumor recurrence in patients with HCC after liver transplantation.