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    Otolin-1 as a biomarker for the evaluation of the effectiveness of betahistine treatment for benign paroxysmal positional vertigo
    (Wolters Kluwer Medknow Publications, 2023) Karaer, Isil Cakmak; Urhan, Ayca; Akalin, Yahya
    ObjectiveBenign paroxysmal positional vertigo (BPPV) is the most common vertigo disorder. Betahistine is the most commonly used drug in the treatment of vertigo, however its effect on the inner ear is not fully known. Otolin-1 is an inner ear-specific glycoprotein that can be identified in peripheral blood. The aim of the study was to determine the effect of treatment of betahistine for BPPV on serum otolin-1 levels.MethodsThirty (30) patients with BPPV and 30 healthy controls were enrolled in the study. Serum otolin-1 levels were measured before and 14 days after perioral (po) betahistine treatment in the BPPV group, whereas otolin-1 level was examined once in controls. The efficacy of treatment was evaluated with Dizziness Handicap Index (DHI) and Visual Analog Scale (VAS) in the BPPV group.ResultsOtolin-1 levels were statistically significantly higher in patients with BPPV than controls. In the BPPV group, serum otolin-1 level was found to be statistically significantly lower after betahistine treatment. There was a statistically significantly difference between pre-treatment and posttreatment groups regarding to both DHI and VAS scores.ConclusionSerum otolin-1 can be used as a biomarker in monitoring the effectiveness of treatment of BPPV with betahistine as well as diagnosis of BPPV.
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    Stress and recurrent aphthous stomatitis
    (2020) Karaer Cakmak, Isil; Urhan, Ayca; Reyhani, Ismail
    Abstract: Recurrent aphthous stomatitis (RAS) is a commonly-encountered oral lesion. The aim of this study was to identify the levels of stress, anxiety and depression in patients with RAS .Fourty (40) patients with RAS and 40 age-matched controls were enrolled in this study. Blood and salivary levels were analyzed electrochemiluminescence technique. The Beck Depression Rating Scale (BDRS) and Beck Anxiety Scale (BAS), Perceived Stress Scale (PSS), and State-Trait Anxiety Inventory (STAI-S and STAI-T) were applied to all participants. There was no statistically significant differences levels between two groups regarding to BDRS, BAS, PSS, STAI-S and STAI-T level. Blood cortisol levels were statistically significantly higher in patients with RAS than controls (12.45 ± 0.74 ?g/dL vs. 9.8± 0.68,respectively,p=0.01), wheras there was no statistically significant difference between women with RAS than controls regarding to salivary cortisol levels (0.33± 0.03 ?g/dL vs. 0.34± 0.03, respectively. Patients with RAS have not higher depression and anxiety levels compared to the control.