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    Detection of Pancreatic Beta Cell Reserve and Its Relationship with Metabolic Markers and Anthropometric Measurements in Patients with Active Psychotic and Mood Disorders
    (2024) Gürok, Mehmet Gürkan; Kilinc, Faruk; Kurt, Osman; Afsar Karatepe, Bercem; Ustundag, Bilal; Uslu, Muhammed Fuad
    Objective: In this research, our objective is to explore how pancreatic beta cell reserve is determined and its correlation with metabolic markers among individuals receiving active treatment for psychotic and mood disorders. Materials and Methods: The study included 60 healthy controls and 60 psychiatrically treated patients on regular antipsychotic medication. Insulin, c-peptide, cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, vitamin D, HbA1c, parathormone, prolactin, TSH levels were analyzed after anthropometric measurements of all participants. Results: The Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) value was notably greater in the case group compared to the control group, with a significant difference observed (p=0.041). Triglyceride (TG), Very low density lipoprotein (VLDL), Total cholesterol and Low density lipoprotein (LDL) values of the case group were significantly higher than the control group. During the correlation analysis, a noteworthy positive correlation was identified between weight and BMI, waist circumference, waist-to-neck ratio, waist-to-hip ratio, insulin levels, and c-peptide levels. Conclusion: We believe that individuals with high-risk factors should undergo regular monitoring for conditions such as obesity, insulin resistance, hyperlipidemia, prediabetes, and diabetes, which can be beneficial.
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    Inflammatory markers and delirium in the intensive care unit
    (Mre Press, 2025) Yildiz, Sevler; Uslu, Muhammed Fuad; Emir, Burcu Sirlier; Kurt, Osman
    Background: Delirium is an important complication in patients admitted to intensive care unit (ICU). However, delirium prediction in patients admitted to the ICU is difficult. Considering the role of neuroinflammation in delirium, peripheral blood-based biomarkers of inflammation pressure could predict delirium. The aim of study was to retrospectively analyze ratios of neutrophil/high density lipoprotein (HDL) (NHR), lymphocyte/HDL (LHR), platelet/HDL (PHR), monocyte/HDL (MHR), as well as systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) in ICU patients diagnosed with delirium. Methods: The study included a total of 2141 patients with or without delirium. The risk factors for delirium development and the predictive power of individual laboratory parameters were evaluated with the Pearson chi-square test, Mann-Whitney U test, Spearman correlation test, logistic regression, and receiver operating characteristic analyses. Results: Length of ICU stay (p < 0.001), NHR (p = 0.035), LHR (p < 0.001), PHR (p = 0.047), MHR (p < 0.001), SIRI (p < 0.001), and SII (p < 0.001) were significantly higher in patients who developed delirium compared to those who did not. A significant negative correlation was found between the duration of delirium and SII (r = -0.260; p = 0.004). Older age, a history of psychiatric treatment, prolonged hospitalization, and high LHR, SIRI, and SII values were determined as risk factors for delirium (p < 0.05 for all). Conclusions: Elevated LHR, SIRI, and SII levels before ICU admission are associated with an increased risk of hyperactive delirium. If confirmed by prospective evidence, readily available biomarkers for inflammation could be used to evaluate the hyperactive delirium risk in ICUs.