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Öğe Assessing safety and efficacy of TNFi treatment in late onset ankylosing spondylitis: a TURKBIO registry study(Nature Portfolio, 2024) Uslu, Sadettin; Gulle, Semih; Sen, Gercek; Cefle, Ayse; Yilmaz, Sema; Kocaer, Sinem Burcu; Yuce Inel, TubaClinical data on the use of tumour necrosis factor inhibitors (TNFi) in late-onset ankylosing spondylitis (LoAS) are limited. The present study aimed to evaluate efficacy, safety, and treatment adherence associated with the initial use of TNFi therapy in biologic naive patients diagnosed with LoAS. Patients whose age of onset was >= 45 years and < 45 years were classified as having LoAS and YoAS, respectively, based on the age of symptom onset. There were 2573 patients with YoAS and 281 LoAS. Baseline disease activity measures were similar between the groups. No significant differences were seen between the two groups in response to treatment and in remaining on the first TNFi at 6, 12 and 24 months. In the LoAS group, the analysis showed that TNFi discontinuation was linked to VAS pain score (HR 1.04; 95% CI 1.01-1.06). Patient groups had similar rates of adverse events (YoAS: 8.7% vs. LoAS: 11.7%). In both biologic naive LoAS and YoAS patients, the study showed that the initial TNFi therapy was equally effective and safe.Öğe Biological treatment in elderly and young patients with ankylosing spondylitis: TURKBIO real-life data results(Turkish League Against Rheumatism, 2024) Uslu, Sadettin; Gulle, Semih; Urak, Ozkan; Sen, Gercek; Dalkilic, Ediz; Senel, Soner; Akar, ServetObjectives: This study aims to investigate the effect of age on disease activity and biological treatment in patients with ankylosing spondylitis (AS). Patients and methods: A total of 811 AS patients registered in the TURKBIO registry database between 2011 and 2019 were categorized according to their age at the time of entry into the registry and assigned to one of two groups: young patients, defined as <60 years of age (n=610), and those aged >= 60 years (n=201) were recorded as elderly patients. Demographic, clinical, and laboratory characteristics, along with disease activity markers and other follow-up parameters, as well as current and prior treatments, were electronically recorded during each visit using open -source software. Results: The mean age of the elderly patients was 67 +/- 5.8 years, while the mean age of the younger patients was 49.2 +/- 10.9 years. Male predominance was lower in the older AS group compared to the younger AS group (p=0.002). During follow-up period, 397 patients (comprising 318 young and 79 elderly individuals) had a history of using at least one biological disease -modifying agent (bDMARD). There was no significant difference between the groups in terms of DMARD and bDMARD-use distributions. First tumor necrosis factor inhibitor (TNFi) retention rates were found to be similar in both groups over 10 years of follow-up. Adverse events were found to be similar in young (19.9%) and elderly (26.8%) AS patients. Conclusion: Research in the TURKBIO cohort reveals that both older and younger patients with AS exhibited similar disease activity levels with comparable treatment approaches. Moreover, the results of TNFi treatments in elderly patients were the same as those observed in younger patients, with no notable increase in safety concerns.Öğe THE EFFICACY AND SAFETY OF ANTI-TNF A TREATMENT IN ANKYLOSING SPONDYLITIS PATIENTS WITH LATE ONSET COMPARED TO THOSE WITH ADULT ONSET; THE DATA FROM TURKBIO REGISTRY(Bmj Publishing Group, 2019) Uslu, Sadettin; Can, Gercek; Cefle, Ayse; Yilmaz, Sema; Kocaer, Sinem Burcu; Inel, Tuba Yuce; Gulle, Semih[Abstract Not Available]Öğe The Efficacy and Safety of Anti-TNF? Treatment in Ankylosing Spondylitis Patients with Late Onset Compared to Those with Adult Onset; The Data from TURKBIO Registry(Wiley, 2019) Uslu, Sadettin; Can, Gercek; Cefle, Ayse; Yilmaz, Sema; Kocaer, Sinem Burcu; Inel, Tuba Yuce; Gulle, Semih[Abstract Not Available]Öğe The Efficacy and Safety of CT-P13 as First-line and Subsequent-line Therapy in Patients with Ankylosing Spondylitis: Real-life Data from TURKBIO Cohort(Wiley, 2022) Uslu, Sadettin; Gulle, Semih; Can, Gercek; Senel, Soner; Capar, Sedat; Dalkilic, Huseyin Ediz; Akar, Servet[Abstract Not Available]
