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    Etiology of Cirrhosis in Turkey: A National Cohort Study
    (Elsevier, 2021) Yildirim, Abdullah Emre; Ucbilek, Enver; Oruncu, M. Berk; Turan, Ilker; Demir, Mehmet; Koksal, Aydin; Uyanikoglu, Ahmet
    [Abstract Not Available]
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    Serum prolidase, urotensin-2 and nesfatin levels in patients with compensated or uncompensated cirrhosis
    (2019) Aydin, Ferzan; Cindoglu, Cigdem; Kirhan, Idris; Uyanikoglu, Ahmet; Yenice, Necati
    Aim: To assess the feasibility of serum prolidase, urotensin-2, and nesfatin measurements as diagnostic and follow-up markers of compensated or uncompensated cirrhosis. Material and Methods: The study included 97 cirrhosis patients and 51 healthy individuals who were admitted to the Internal Medicine and Gastroenterology Clinics of Harran University Research and Application Hospital between May 2014 and June 2015. Patients with esophageal variceal bleeding, ascites, hepatic encephalopathy were considered as having decompensated cirrhosis. Blood samples obtained from patient and control groups were stored at -85 C. ELISA methodology was used for measurements.Results: A total of 97 cirrhotic patients (43 with compensated and 54 with decompensated cirrhosis) with a median age of 53.98±15.67 years (range: 19-89) were included in the study. Serum prolidase, urotensin-2, and nesfatin in patients with cirrhosis compared to 51 healthy controls. Serum prolidase levels were significantly lower in the overall group of patients with cirrhosis as well as in the decompensated cirrhotic patients as compared to controls (p0.001). Urotensin-2 was significantly lower in the compensated cirrhosis group than in controls (p0.05). Nesfatin was significantly higher in the overall and decompensated cirrhotic than in controls (p0.05).Conclusion: Our results suggest that serum prolidase levels can be used as a marker for diagnosis and follow-up in patients with decompensated cirrhosis and that urotensin-2 may play a role in the pathogenesis of cirrhosis. Again, a higher nesfatin level in the overall and decompensated cirrhosis patients was suggestive of its potential role in the development of loss of appetite and cachexia characteristic of advanced cirrhosis as well as a role as a potential marker.Keywords: Cirrhosis; prolidase; urotensin-2; nesfatin.
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    Should colonoscopy screening be performed in patients with adnexal mass?
    (2018) Uyanikoglu, Hacer; Tatli, Faik; Uyanikoglu, Ahmet
    Aim: Besides primary ovarian tumor, a part of adnexal masses are metastatic colorectal cancers (CRC). Additionally, the risk of CRC is increased if the genitourinary cancers are present. In this study, we want to examine the separation of primer ovarian tumor and colorectal tumor metastasis and we investigated whether the routine colonoscopy is necessary in patients with adnexal mass. Material and Methods: This study included 58 women who underwent colonoscopy due to adnexal mass (Group 1) and 438 women who underwent colonoscopy for other reasons (Group 2). The colonoscopy results compared retrospectively in both groups between March 2014 and June 2016 at Harran University, Faculty of Medicine. Results: DThe mean age were 46.18 ± 16.89 (range 20-84) and 48.72± 17.95 (range 20-94) years in group 1 and 2, respectively. CRC was seen in two women (3.4%) and polyp in five (8.6%) in group 1. However, CRC was detected in 22 women (5%) and polyp in 71 (16.3) in group 2. The incidences of CRC and polyp were found to be lower in women with adnexal mass than group 2. Conclusions: The incidences of CRC and polyp were found to be lower in women with adnexal mass than those of without adnexal mass. Nevertheless, routine colonoscopy screening should be considered for women with adnexal mass due to the difficulties in the discrimination of primary and metastatic ovarian cancer in preoperative period.