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Öğe Anticonvulsant activity of some new Nafimidone derivatives: Effects on GABA metabolism(Wiley-Blackwell, 2015) Uyumlu, A. B.; Satilmis, B.; Batcioglu, K.; Alagoz, M. A.; Karakurt, A.; Genc, M. F.[Abstract Not Available]Öğe The effects of different industrial sugars on royal jelly production(Hellenic Veterinary Medical Soc, 2022) Karlidag, S.; Koseman, A.; Akyol, A.; Yil, G.; Seker, I.; Uyumlu, A. B.; Yilmaztekin, M.In this study, the larval acceptance rate and the royal jelly yield in honeybee (Apis mellifera L.) colonies supplemented with different industrial sugars at different locations were determined. For this purpose, feeding groups (1. Sucrose group, 2. Glucose group, 3. Bee feed syrup group, 4. Control group) and locations (1. Battalgazi, 2. Dogansehir) were formed. In queenless colonies that produce royal jelly, in order to sustain 5-15 day-old young feeder worker bees, two sealed frames with brood from support colonies were added. The royal jelly yield was harvested seven times. Based on the location, the feeding groups, and the location x feeding groups interaction, 12600 larvae were grafted, 9054 larvae were accepted, and the larval acceptance rate was determined as 71.86%. Based on the location, feeding groups and the location x feeding group interaction, the yield per cell was calculated as 213.15 +/- 11.53 mg/ cell, the yield per colony as 6.88 +/- 0.38 g/app., and the total yield per colony as 34.40 +/- 1.91 g/colony. In the study, no statistically significant difference was determined between feeding with sucrose, bee feed and the supplementary feeding with glucose. On the other hand, it was determined that the location where the royal jelly was produced affected both the larval acceptance and the royal jelly yield.Öğe Investigation of in vivo radioprotective and in vitro antioxidant and antimicrobial activity of garlic (Allium Sativum)(Verduci Publisher, 2012) Batcioglu, K.; Yilmaz, Z.; Satilmis, B.; Uyumlu, A. B.; Erkal, H. S.; Yucel, N.; Gunal, S.OBJECTIVE, In this study, we aimed to assess the in vivo antioxidant potential via evaluating radioprotective effects in kidney and liver tissues of rats and in vitro antimicrobial and radical scavenger activity of garlic extract. MATERIALS AND METHODS, Thirty-two mature female Wistar rats were divided into four groups, each consisting of eight rats. Experimental groups were control group (1), GE group (2), irradiation group (3) and both GE and irradiation group (4). For the rats in two groups (group 3 and 4), irradiation was performed on a Cobalt-60 unit using a single fraction of 20 Gy. The GE was given to rats once a day during the month before irradiation and continued for five days after irradiation. The garlic cloves were peeled on crushed ice and 50 g of garlic was cut into small pieces and homogenized in 75 mL of 0.9% NaCl. The concentration of this garlic preparation was considered to be 500 mg/mL on the basis of weight of the starting material (0.5 g/mL). This extract was administered to rats by oral gavage. RESULTS, Our findings suggest that the use of garlic extract could be useful for addressing the limited therapeutic gain due to the radiation sensitivity of normal tissues adjacent to the tumour which are exposed to radiation, by strengthening the antioxidant system. In vitro and in vivo experiments seem to yield similar conclusions. CONCLUSIONS, It can be stated that garlic is may be recommended to be sufficiently included in the diets of radiotherapy patients considering its antioxidant and antimicrobial efficacy.Öğe Liver lipid peroxidation and antioxidant capacity in cerulein-induced acute pancreatitis(Assoc Bras Divulg Cientifica, 2009) Batcioglu, K.; Gul, M.; Uyumlu, A. B.; Esrefoglu, M.The aim of this study was to evaluate the role of oxidative damage in pancreatitis-induced hepatic injury. Thirty-five rats were divided into five groups (each of 7 rats): control, cerulein (100 mu g/kg body weight), cerulein and pentoxifylline (12 mg/kg body weight), cerulein plus L-NAME (10 mg/kg body weight) and cerulein plus L-arginine (160 mg/kg body weight). The degree of hepatic cell degeneration differed significantly between groups. Mean malondialdehyde levels were 7.00 +/- 2.29, 20.89 +/- 10.13, 11.52 +/- 4.60, 18.69 +/- 8.56, and 8.58 +/- 3.68 nmol/mg protein for the control, cerulein, pentoxifylline, L-NAME, and L-arginine groups, respectively. Mean catalase activity was 3.20 +/- 0.83, 1.09 +/- 0.35, 2.05 +/- 0.91, 1.70 +/- 0.60, and 2.85 +/- 0.47 U/mg protein for the control, cerulein, pentoxifylline, L-NAME, and L-arginine groups, respectively, and mean glutathione peroxidase activity was 0.72 +/- 0.25, 0.33 +/- 0.09, 0.37 +/- 0.04, 0.34 +/- 0.07 and 0.42 +/- 0.1 U/mg protein for the control, cerulein, pentoxifylline, L-NAME, and L-arginine groups, respectively. Cerulein-induced liver damage was accompanied by a significant increase in tissue malondialdehyde levels (P < 0.05) and a significant decrease in catalase (P < 0.05) and GPx activities (P < 0.05). L-arginine and pentoxifylline, but not L-NAME, protected against this damage. Oxidative injury plays an important role not only in the pathogenesis of AP but also in pancreatitis-induced hepatic damage.
