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Öğe Akondrogenezis Tip 1A: Olgu Sunumu(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2007) Güler, Ekrem; Karabiber, Hamza; Uzel, Murat; Mehmet Davutoğlu, Mehmetİntrauterin kemik kırıklarına neden olan ve fatal seyreden bir iskelet displazi sendromu akondrogenezisin literatür eşliğinde tartışılması. Akondrogenezis ileri derecede kısa ekstremiteler, gövdede kısalık ve makrosefali ile karakterize, otozomal resesif kalıtımla geçiş gösteren, nadir görülen fatal seyirli bir hastalıktır. Doğum sonrasında solunum sıkıntısı, ekstremitelerinde aşırı kısalık ve kafa büyüklüğü nedeniyle kliniğimize sevk edilen ve bir kardeşinde de cücelik nedeniyle terapötik abortus yapılan klinik ve radyolojik olarak akondrogenezis tip 1A düşünülen bir hasta sunuldu. Akondrogenezisler otozomal resesif geçiş gösterirler ve letal displazilerdir, bu nedenle aile hikâyesi ve prenatal tanı önemlidir.Öğe Epidemiology and outcomes of Candida-associated osteoarticular infections: A multicentre retrospective study from Turkey(Oxford Univ Press, 2025) Guler, Ozlem; Uzel, Murat; Tepe, Dilsat; Aksoy, Firdevs; Cinar, Gule; Memikoglu, Kemal Osman; Durdu, BulentThis multicentre retrospective study investigated the epidemiology, clinical characteristics, and fluconazole resistance rates of Candida species in osteoarticular infections across Turkey as well as the factors influencing complete recovery. Data were gathered from 73 adult patients diagnosed with proven or probable Candida-associated osteoarticular infections between 2015 and 2025 from 20 healthcare centres. The most common clinical presentation was spondylodiscitis, followed by the involvement of phalangeal bones in the hands and feet. Non-albicansCandida species accounted for 37/73 cases (50.7%), with Candida parapsilosis being the most frequent. Fluconazole resistance was low among C. albicans isolates (3%) but higher among non-albicans yeasts (27%). Bacterial co-infection, predominantly Gram-positive bacteria, was detected in 52.1% of cases. Diabetes was present in 50/73 patients (68.5%), particularly insulin-dependent diabetes, and was a prominent comorbidity that may have also contributed as a predisposing factor. Radiological detection of osteomyelitis was achieved in 69.9% of patients. Fluconazole was the most commonly used antifungal agent (74%) with a median treatment duration of 90 days. Multivariate analysis revealed that surgical debridement was significantly associated with a higher odds of clinical recovery (adjusted odds ratio [aOR], 5.764; 95% confidence interval [CI], 1.360-24.434; P = .017), whereas diabetes mellitus was significantly associated with a lower odds of total recovery (aOR, 0.205; 95% CI, 0.053-0.792; P = .022). In conclusion, this multicentre study provides epidemiological data and fluconazole resistance rates of Candida species causing osteoarticular infections in Turkey, highlights the occurrence of C. auris in this cohort, and identifies surgical intervention and diabetes mellitus as factors significantly associated with recovery. This study analysed bone and joint infections with the yeast Candida from multiple Turkish hospitals over 10 years. Non-Candida albicans species were the most common (50.7%). The spine bones and discs were mostly affected. Diabetes was a key risk factor. Treatment generally lasted around 90 days.Öğe Hand Grip and Pinch Strength in Patients With Nocturnal Enuresis: Is There a Role of Muscle Strength in Pathogenesis of Enuresis?(Wiley, 2011) Karabiber, Hamza; Garipardic, Mesut; Uzel, Murat; Davutoglu, Mehmet; Ozer, Ali; Hasturk, Ziyadeddin; Guler, EkremAims: To examine the association of muscle strength with nocturnal enuresis. Subjects and Methods: One hundred sixty-three patients with monosymptomatic nocturnal enuresis (8-14 years old) were recruited from outpatient clinics. Two hundred eight healthy students served as the control group (8-14 years old) from two primary schools. Physical examinations and the age, gender, height, weight, dominant hand, and body mass of these children index were recorded. A calibrated, Jamar dynamometer was used to assess grip strength at the first two settings. A pinch gauge was used to assess the key pinch of the right and left hands of these children. Two measurements of each grip and pinch were obtained at 15 sec intervals and mean values were analyzed. Results: The hand grip strength test and pinch was significantly lower in the enuretic group compared with the control group. These low results of the muscle strength in the enuretic group showed that whole body muscle weakness may contribute to the pathogenesis of enuresis as a possible etiological factor. Conclusions: In this first study on the association of muscle strength with nocturnal enuresis, it was found that neuromuscular function is abnormal in enuretic patients. In this neuromuscular abnormality, the motor activity is affected. Neurourol. Urodynam. 30:525-528, 2011. (C) 2011 Wiley-Liss, Inc.Öğe Rare presentation of human orf as multiple lesions(Wiley-Blackwell, 2011) Sasmaz, Sezai; Uzel, Murat; Sener, Serpil; Ucmak, Hasan[Abstract Not Available]
