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    Evaluation of sleep quality and daytime sleepiness in nurses
    (2019) Uzer, Fatih; Kirhan, Idris
    Aim: In this study, it was aimed to experimentally investigate the protective effects of melatonin in the cisplatin-induced ototoxicity.Material and Methods: Ten Wistar-albino rats were included in the study. Two equal groups were generated randomly as cisplatin and melatonin groups. Rats’ underwent Auditory Brainstem Response (ABR) and Distortion Product Otoacoustic Emission (DPOAE) testing before the drug administration and the results were recorded. Both tests were repeated 72 hours after the cisplatin administration in all rats.Results: Significant difference was found between the I-IV interval values before the treatment and after the treatment both in cisplatin and melatonin group. As well as the significant difference in hearing threshold value changes, statistically, significant differences in ABR-I and ABR-IV interval variations were also seen between the cisplatin and melatonin groups. A statistically significant decrease was found between the initial and final control SNR (signal-to-noise ratio) levels within the cisplatin group in the evaluations at 2000Hz, 3000Hz and 4000Hz. Statistically, significant differences were observed between SNR levels when the melatonin group was compared with the cisplatin group. Conclusion: Melatonin appears to reduce cisplatin-induced ototoxicity in rats. Although, the use of supplementary therapies targeting to reduce the toxic effects in clinical studies is still a controversial point.
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    Examination of pulmonary embolism in patients in a university hospital
    (2020) Kirhan, Idris; Uzer, Fatih; Hocanli, Iclal; Turan, Hamdiye
    Aim: Pulmonary embolism (PE) is responsible for 5-15% of hospital deaths. The rate of mortality from PE in untreated cases is about 25-30%, while this rate drops down to 2-8% in treated cases. In this study, we aimed to investigate general features of the patients hospitalized in our center due to PE and the factors affecting prognosis. Material and Methods: Patients hospitalized due to PE in Harran University Medical Faculty Hospital between January 2015 and December 2017. Patients’ demographic data, comorbidities, hemogram outcomes at the time of admission, liver function tests, renal function tests, electrolytes and cardiac markers, status of the patients during follow-up (referral to intensive care unit, exitus, ward follow-up) and PE clinical picture (massive, submassive, nonmassive) were recorded. All patients requiring hospitalization due to PE were included in the study, while patients with chronic thromboembolic pulmonary disease, those requiring recurrent hospitalization and patients discharged on own demand were excluded from the study.Results: The study included 40 (38.8%) male and 63 (61.2%) female patients with a mean age of 66±18.1 years. The mean duration of hospitalization was found as 11 days. Of the patients included in this study, 7.7% (n=8) were diagnosed with massive, 10.6% (n=11) with submassive, and 81.5% (n=84) with non-massive PE. Four patients (3.8%) were accepted as in-hospital exitus, 30 (29.1%) patients were transferred to the intensive care unit and 69 (66.9%) patients were followed-up in the thoracic diseases service. When patients diagnosed with non-massive PE were compared with those diagnosed with submassive and massive PE; the levels of magnesium (p=0.003), and troponin (p=0.000) were statistically significantly higher in the group diagnosed with submassive and massive PE. When the groups with and without the need for intensive care were compared, platelet counts were statistically lower in the group which required intensive care (p=0.038).Conclusion: More often hospitalization is needed in female patients due to PE. Although routine laboratory tests give a partial information about the prognosis of PE, cardiac markers are the most commonly used in clinical practice.