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    Clinicopathologic features of operated gastric cancer patients, single center nine years experience
    (2020) Yol, Sinan; Uzun, Orhan; Senger, Aziz Serkan; Dincer, Mursit; Polat, Erdal; Duman, Mustafa; Deger, Kamuran Cumhur; Cigiltepe, Huseyin; Gundes, Ebubekir; Cetin, Durmus Ali; Aday, Ulas
    Aim: Gastric cancer is one of most common malignancies in the world. In developed countries including Europe and United States, despite the advanced technology, advanced stages of gastric cancer are still common with a poor survival. In this study, we aimed to describe clinicopathological characteristics and outcomes of gastric cancer in patients who were operated in our clinic.Material and Methods: We respectively evaluated a total of 200 patients who underwent gastrectomy, D2 lymph node dissection due to gastric cancer between November 2006 and December 2015. Data including clinicopathologic features, postoperative complications, overall survival and prognostic factors affecting prognosis were analyzed and statistical analysis was performed. Data including clinicopathologic features, postoperative complications, overal survival and prognostic factors affecting prognosis were analyzed and statistical analysis was performed.Results: Of the patients, 134 (67%) were males and 66 (33%) were females. The mean age was 61.36±11.92 (28-91) years. Tumor localization was frequently low (57%). The most common postoperative complication, regardless of the type of gastrectomy, was the surgical site infection. The major of the patients had Stage 3 disease. The median overall survival was 24.9 (0.07-116.3) months and overall survival was 43.7%.Conclusion: Except for early stage, the chance of curative treatment is low in gastric cancer. Early diagnosis and treatment can yield improved outcomes for this patient population. Therefore, it is important to develop national programs for early diagnosis and to develop experienced endoscopists
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    Comparison of first-line eradication therapy protocols for Helicobacter pylori in regions with high clarithromycin resistance
    (2019) Bozkurt, Hilmi; Sert, Ozlem Zeliha; Kaplan, Esin; Aray, Emre; Olmez, Tolga; Uzun, Orhan; Koksal, Rabia; Polat, Erdal; Duman, Mustafa
    Aim: First-line eradication therapy protocols for Helicobacter pylori infection and their success rates still prove to be matter of interest for researchers. The aim of this study was to examine retrospectively eradication therapy protocols used in patients infected with H. pylori in our region with high resistance to clarithromycin, compare success rates and determine the factors affecting success rates. Material and Methods: Eradication therapies for dyspeptic patients who were found to be Helicobacter pylori positive as revealed by upper gastrointestinal endoscopy and biopsy results and success rates attained in the microscopic examination of stool in the 4th week after the therapy were analyzed. Group 1 (legacy triple therapy): clarithromycin 500 mg film-coated tablet 2x1, lansoprazole 30 mg capsule 2x1, amoxicillin 1000 mg tablet 2x1, 14-day therapy period; Group 2 (bismuth-free quadruple therapy): clarithromycin 500 mg film tablet 2x1, rabeprazole 20 mg tablet 2*1, amoxicillin 1000 mg tablet 2x1, metronidazole 500mg 2x1 tablet, 14-day therapy period; Group 3 (bismuthal quadruple therapy): bismuth subsalicylate 262 mg tablet 2x2, metronidazole 500 mg tablet 3x1, tetracycline 500 mg capsule 3x1, pantoprazole 40mg tablet 2x1, 10-day therapy period.Results: Data of 168 patients were analyzed. The patients were divided into Group 1 (classical therapy) with 80 patients, Group 2 (bismuth-free quadruple therapy) with 46 patients and Group 3 (bismuthal quadruple therapy) with 42 patients. Eradication success rates were as follows: Group 1 (80%), Group 2 (80.4%) and Group 3 (83.3%).Conclusion: Antibiotic resistance is the sole reason for the low success rate in eradication therapy for Helicobacter pylori. In regions with high clarithromycin resistance bismuth-free quadruple therapy can be employed as an alternative. In regions with metronidazole resistance in addition to clarithromycin resistance bismuthal therapy protocols can be employed. Keywords: Helicobacter pylori; eradication therapy; clarithromycin resistance.
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    A rare submucosal gastric tumor: Gastric schwannoma
    (2018) Cetin, Durmus Ali; Ciyiltepe, Huseyin; Aday, Ulaş; Gundes, Ebubekir; Bozdag, Emre; Uzun, Orhan
    Schwannomas, which arise from the Schwann cells of the neural plexus on the gastric wall, are slow-growing, generally asymptomatic and frequently benign neoplasms. Gastric schwannomas account for only 0.2% of all gastric tumors. Gastrointestinal stromal tumors (GIST) should firstly be taken into consideration in the differential diagnosis of submucosal mass lesions originating from the gastric wall. Gastric schwannomas and GISTs are generally seen in middle-aged patients and they have similar clinical characteristics. Surgical resection is the selected treatment method for gastric schwannomas. Definitive diagnosis is achieved through histopathological and immunohistochemical analyses. The aim of this study was to present the case of a patient who had presented with anemia symptoms, received laparoscopic resection because of gastric submucosal mass lesion, and diagnosed with gastric schwannoma.
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    A rare submucosal gastric tumor: Gastric schwannoma
    (2018) Uzun, Orhan; Bozdağ, Emre; Gündeş, Ebubekir; Aday, Ulaş; Çiyiltepe, Hüseyin; Çetin, Durmuş Ali
    Abstract:Schwannomas, which arise from the Schwann cells of the neural plexus on the gastric wall, are slow-growing, generally asymptomatic and frequently benign neoplasms. Gastric schwannomas account for only 0.2% of all gastric tumors. Gastrointestinal stromal tumors (GIST) should firstly be taken into consideration in the differential diagnosis of submucosal mass lesions originating from the gastric wall. Gastric schwannomas and GISTs are generally seen in middle-aged patients and they have similar clinical characteristics. Surgical resection is the selected treatment method for gastric schwannomas. Definitive diagnosis is achieved through histopathological and immunohistochemical analyses. The aim of this study was to present the case of a patient who had presented with anemia symptoms, received laparoscopic resection because of gastric submucosal mass lesion, and diagnosed with gastric schwannoma.
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    Report of case: Fluoxetine-associated symptomatic hyponatremia in the young woman without comorbidity
    (2020) Gundogmus, Ibrahim; Tasci, Azize Beril; Akgun, Abdullah; Kaymak Polat, Derya; Bolu, Abdullah; Uzun, Orhan