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Öğe Concentrations of copper, zinc and various elements in serum of patients with bronchial asthma(Gustav Fischer Verlag, 2000) Vural, H; Uzun, K; Uz, E; Koçyigit, A; Çigli, A; Akyol, ÖIn this study, serum copper, zinc, magnesium, iron and calcium concentrations were investigated in 40 patients with bronchial asthma (BA) and in 43 healthy subjects. Copper and calcium levels were found to be increased in patients with BA compared to the control group (p<0.001 and p<0.001 respectively). On the other hand, the serum zinc level was significantly lower in healthy subjects (p<0.01). No changes were found in serum magnesium and iron levels in patients with BA compared to controls. In addition to various elements, certain serum proteins such as albumin, transferrin and ferritin were also assessed to determine whether there was a relationship between the elements and proteins in patients with BA. There was only a significant decrease in albumin concentration in patients with BA (p<0.05).Öğe Concentrations of trace elements in larynx and skin tissues with epidermoid cancer(Dustri-Verlag Dr Karl Feistle, 2004) Kizilay, A; Kalcioglu, MT; Ozyurt, H; Vural, H; Sogut, S; Cokkeser, Y; Akyol, OBackground and objectives: Playing a crucial role in a number of biological processes, trace elements are an essential part of the body. Up to now, trace elements-cancer relationships have not had a definitive explanation. This study was scheduled to investigate the trace element content of squamous cell carcinoma of the larynx and skin. Methods: The study was designed as a prospective controlled study. Tissue concentrations of iron, selenium, copper and zinc were studied in 30 patients with squamous cell carcinoma (19 larynx and 11 skin), while 20 tissues (12 larynx and 8 neck) of non-cancerous patients served as control. All samples were taken during surgical operations. Tissue element concentrations were measured by atomic absorption spectrophotometer after tissues were digested in an acid mixture. Results: No meaningful differences were interpreted in copper and zinc in epidermoid cancer and non-cancerous tissues. However, iron and selenium concentrations were found to be decreased significantly in cancer tissues than in control values. Conclusion: Decreased selenium and iron concentrations in the cancerous tissue from the patients with epidermoid cancer may result in increased oxidative stress because of the requirements of these elements for activities of some antioxidant enzymes.Öğe Effect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic children(Humana Press Inc, 2004) Armutcu, F; Ozerol, E; Gurel, A; Kanter, M; Vural, H; Yakinci, C; Akyol, OAntiepileptic drugs could cause changes in the trace element status of the body. Valproic acid (VPA) is a very effective anticonvulsant agent widely used in the management of various forms of epilepsy. Nail trace element content is a reliable index of trace element nutritional status of the body. To determine whether some of the side effects of antiepileptic drugs could be the result of zinc (Zn) depletion within tissues, Zn concentrations as well as copper (Cu) concentrations in nail and serum in 59 children having various types of epilepsy receiving valproate and 31 controls were assessed. Although serum Zn level in epileptic patients was found to be decreased, there was no difference in nail samples when compared to controls. There was a statistically significant increase in nail Cu level in epileptic patients when compared to controls. On the other hand, serum Cu levels were not different between the groups. Although none of our patients showed any symptoms of Cu elevation and Zn depletion, we should pay attention to potential body trace element changes in patients with epilepsy under VPA treatment. In conclusion, our results indicate that serum trace metal homeostasis might be affected by VPA therapy, but not by the convulsive disorder itself.Öğe Effects of interesterified vegetable oils and sugar beet fibre on the quality of Turkish-type salami(Wiley, 2005) Javidipour, I; Vural, H; Özbas, ÖÖ; Tekin, ATurkish-type salami is an emulsion type product that is only shelf stable at chilling temperature. The use of three interesterified vegetable oils (IVOs) prepared from either palm, cottonseed or olive oil (IPO, ICO and IOO, respectively) together with 2% sugar beet fibre (SBF) (<425 mum) was studied in the production of Turkish-type salami. These compounds were used to modify the fatty acid composition and increase the dietary fibre content of the traditional product. Beef fat (10%) was replaced by one of the IVOs at either 60 or 100%. The addition of SBF significantly increased (P < 0.05) the total dietary fibre content and water-holding capacity of salamis. Incorporation of IVOs improved the nutritional content of the product because it altered the fatty acid composition. It was found that total or partial replacement of beef fat by IVOs, as well as the presence of 2% SBF, did not lead to significant changes in appearance, colour, texture, flavour or sensory score. The use of IVO and SBF as fat substitutes could be used to obtain a low fat product with high dietary fibre and a modified fatty acid composition.Öğe Effects of interesterified vegetable oils and sugarbeet fiber on the quality of frankfurters(Elsevier Sci Ltd, 2004) Vural, H; Javidipour, I; Ozbas, OOThe effects of interesterified vegetable oils (IVOs) prepared from palm, cottonseed and olive oil, respectively, and sugarbeet fiber (SBF) on quality of frankfurters have been studied. Beef fat (10%) was replaced by one of the IVOs for 60% and 100%. Incorporation of IVOs in frankfurters improved the nutritional content of product due to altering the fatty acid composition. The oleic acid content of frankfurters increased from 28.76% to 45.57% and 47.15% as the interesterified palm oil (IPO) and interesterified olive oil (100) contents increased from 0% to 10% and 6%, respectively. The linoleic acid contents of 6% and 10% interesterified cottonseed oil (ICO) added frankfurters were, respectively, 10- and 19.6-fold higher than treatments without ICO. Addition of SBF (<425 mum size and 1% level) significantly increased (p < 0.05) the total dietary fiber content and water-holding capacity (WHC) of frankfurters. Incorporation of IVOs and SBF did not lead to significant changes in appearance, colour, texture, flavour or sensory scores. It is concluded that IVOs and SBF may be successfully applied as beef fat substitute in frankfurters since this combination offset some of the changes brought about by beef fat replacement. (C) 2003 Elsevier Ltd. All rights reserved.Öğe Effects of sugarbeet fiber on the quality of Frankfurters(Verlag Dr Albert Bartens, 2003) Özboy-Özbas, Ö; Vural, H; Javidipour, IThe effects of sugarbeet fiber (SBF) on the quality and dietary fiber content of Frankfurters have been investigated. Dried and ground sugarbeet fiber was added to emulsions at addition rates of 1-3%. SBF preparations of fine (< 425 mm), medium (425-850 mm) and coarse (850-1000 mm) particle sizes were used in the production of Frankfurters. SBF was produced from beet pulp collected after pressing. The protein and the dietary fiber contents (acid detergent fiber, neutral detergent fiber and total dietary fiber) increased as the particle size of the SBF samples increased. The dietary fiber content results on SBF samples indicate that the beet pulp may be used as an attractive dietary fiber source. The fat content of Frankfurters to which SBF had been added decreased significantly as the level of SBF increased. The water content of Frankfurters with SBF incorporated increased significantly (p < 0.05) as the percentage of SBF increased. As expected, with the total dietary fiber content of Frankfurters increased significantly (level of significance p < 0.05) as the SBF level increased. Frankfurters containing fine SBF gave higher consumer acceptability than batches to which coarse and medium SBF had been added especially at lower addition levels. The use of SBF as a fat substitute could be a good alternative to offer both high DF and low-fat food products.Öğe Hair lead and cadmium concentrations in patients with epilepsy and migraine(Wiley, 2003) Sasmaz, S; Uz, E; Pinar, T; Vural, H; Eiri, M; Ilhan, A; Akyol, ÖEpilepsy and migraine are neurological manifestations of neurocutaneous diseases. The studies that investigate the etiology of these manifestations may illuminate the physiopathological bases of neurocutaneous disorders. The hypothesis that the elevation of toxic trace element concentration in the brain is an important triggering factor for seizures and subsequent neuronal damage in epilepsy and migraine was investigated in this clinical prospective study. The levels of two heavy metals (lead [Pb] and cadmium [Cd]) in scalp hair were measured in patients with epilepsy (n=33) and migraine (n=40) as well as healthy control subjects (n=26). The hair concentration of these two toxic trace elements was determined by atomic absorption spectrophotometry. There was a significant increase in Pb concentration in epilepsy group when compared to both control (p<0.006) and migraine group (p<0.02). There was no difference in mean Cd concentration of hair from epilepsy, migraine patients and control groups. Therefore, no conclusive findings were obtained for Cd. Elevated Pb content in epileptic patients was accepted as being of particular importance. Our findings support the hypothesis that the elevation in Pb concentration in the scalp hair amongst patients with epilepsy may show the elevation in the brain and constitute an important triggering factor for seizures.Öğe Is the arginine-nitric oxide pathway involved in the pathogenesis of schizophrenia?(Karger, 2003) Yanik, M; Vural, H; Kocyigit, A; Tutkun, H; Zoroglu, SS; Herken, H; Savas, HAThe reciprocal regulation of arginase and nitric oxide synthase (NOS) in L-arginine-metabolizing pathways has been demonstrated. There are various evidences of the role of the nitric oxide (NO) in several neuropsychiatric disorders including schizophrenia. However, there is no study which has investigated the role of arginase as an important part of the arginine regulatory system affecting NOS activity in schizophrenia. This study aims to investigate arginase, manganese (Mn) and total nitrite levels (a metabolite of NO) and their relationship to the arginine-NO pathway in patients with schizophrenia. Arginase activities, Mn and total nitrite levels were measured in plasma from 46 patients with schizophrenia and 32 healthy control subjects. Plasma arginase activities and Mn were found to be significantly lower and total nitrite level higher in patients with schizophrenia compared with controls. Our results suggest that the arginine-NO pathway is involved in the pathogenesis of schizophrenia. Copyright (C) 2003 S. Karger AG, Basel.Öğe The role of the arginine-nitric oxide pathway in the pathogenesis of bipolar affective disorder(Springer Heidelberg, 2004) Yanik, M; Vural, H; Tutkun, H; Zoroglu, SS; Sava, HA; Herken, H; Koçyigit, AThere is a reciprocal regulation of arginase and nitric oxide synthase (NOS) in L-arginine-metabolizing pathways. Nitric oxide (NO) may be involved in some psychiatric disorders like schizophrenia, depression and bipolar affective disorder (BPAD). To our knowledge, there is no study in the literature in which the role of arginase, an important part of the arginine regulatory system affecting NOS activity, was investigated in BPAD. This study aims to investigate arginase, manganese (Mn) and total nitrite levels (a metabolite of NO) and their relationship to the arginine-NO pathway in patients with BPAD. Arginase activities, Mn and total nitrite levels were measured in plasma from forty-three patients with BPAD (Type one) and thirty-one healthy control subjects. Plasma arginase activities and Mn were found to be significantly lower and total nitrite level higher in patients with BPAD compared with controls. Our results suggest that the arginine-NO pathway is involved in the pathogenesis of BPAD.Öğe Utilization of sugarbeet fiber in low-fat Turkish-type salami(Verlag Dr Albert Bartens, 2004) Vural, H; Özboy-Özbas, Ö; Javidipour, IIn this study, the effects of sugarbeet fiber (SBF) on the quality and dietary fiber content of Turkish type salami have been investigated. Dried and ground sugarbeet fiber was added to emulsions at addition rates of 2, 4 and 6%. SBF preparations of fine (<425 pm), medium (425-850 mu m) and coarse (850-1000 mu m) particle sizes were used in the production of Turkish type salami. SBF was produced from sugarbeet pulp collected after pressing. The protein and the dietary fiber contents (acid detergent fiber, neutral detergent fiber and total dietary fiber) increased, as the particle size of the SBF samples increased. Turkish type salami formulated with SBF had a higher (p < 0.05) water content and water holding capacity values and lower fat content, color and texture values than those of the control. The results showed that 2, 4 and 6% of fine SBF can be used to replace fat because it offset some of the changes brought about by fat reduction. Sugarbeet fiber is also found to be suitable for fiber-enrichment of salami products.
