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    Superior Electrochemical Sensor Application of Co3O4/C Heterostructure in Rapid Analysis of Anticancer Drug Palbociclib in Pharmaceutical Formulations and Biological Fluids
    (Amer Chemical Soc, 2024) Vural, Ozgul; Bugday, Nesrin; Genc, Asena Ayse; Erk, Nevin; Duygulu, Ozgur; Yasar, Sedat
    In this work, we report a study examining how different salt concentrations affect the structure and electrochemical performance of two Co3O4/C materials designed for the fabrication of an easy, cheap, fast, safe, and useful electrochemical sensor for the detection of Palbociclib (PLB). Co3O4 nanoparticles were successfully created by encapsulating them in N-doped amorphous carbon matrices by using the molten salt-assisted approach. In this process, different amounts of potassium iodate and zeolitic imidazolate framework-12 (ZIF-12) were used, followed by pyrolysis at 800 degrees C. Optimum Co3O4 embedded porous carbon structures were obtained, and the composite with the highest electrochemical properties was modified to a glassy carbon electrode (GCE) surface for PLB detection. The linear response spanned from 1.0 to 5.0 mu M, featuring a limit of detection (LOD) of 0.122 mu M and a limit of quantification (LOQ) of 0.408 mu M; the correlation coefficient was calculated as 0.995. The high sensitivity of the method in detecting PLB in pharmaceutical samples and human urine demonstrated its feasibility, with recovery percentages ranging from 99.3% to 101.3% and relative standard deviation (RSD) values of <3%. Therefore, this technique will make a significant contribution to monitoring and improving existing cancer treatment options.