Yazar "Yürekli M." seçeneğine göre listele

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    Adrenomedullin and nitric oxide in children with detrusor instability
    (Springer Verlag, 2003) Balat A.; Sarica K.; Çekmen M.; Yürekli M.; Ya?ci F.; Erba?ci A.
    Detrusor instability (DI) and detrusor-external sphincter dyssynergia lead to poor bladder emptying and high bladder pressure. Recent results indicate that nitric oxide (NO) is an important transmitter or messenger molecule in autonomic neurotransmission. Adrenomedullin (AM) is a potent vasodilator and natriuretic peptide, originally purified from human pheochromocytoma. Since NO and AM have vasodilatory effects on smooth muscles, we considered them to be of interest in children with DI. We determined the tissue levels of NO and AM in 14 children with DI, and compared these with 6 children with normal bladder activity. Bladder biopsy total nitrite levels (nmol/g tissue) were decreased in children with DI (10.69±0.91 vs. 12.83±0.98, P<0.01). However, AM levels (pmol/g tissue) were increased in the same patients (48.84±3.52 vs. 28.79±1.53, P<0.001). According to our results, decreased NO production probably has a role in the pathophysiology of DI, although increased AM appears to be compensatory. NO may provide a therapeutic target in clinical situations related to DI. However, the functional significance of AM and NO in bladder smooth muscle remains to be determined by further detailed studies.
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    Circulating adrenomedullin levels in ankylosing spondylitis and familial mediterranean fever
    (Elsevier Masson SAS, 2008) Üreten K.; Özbek M.; Öztürk M.A.; Dogru I.; Dogru A.; Yürekli M.; Karakurt F.
    [No abstract available]
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    Contribution of adrenomedullin to homeostatic response to cold stress in rat model
    (2002) Yüksel Ş.; Akbay A.; Yürekli M.
    Acute stress known to stimulate sympathetic activity as well as the hypothalamo-pituitary-adrenal (HPA) axis, produces a significant increase in adrenomedullin (ADM) levels in the pituitary gland, plasma and adrenal glands, all of which are key components of HPA axis, suggesting a regulatory or protective role for ADM in countering HPA activation following a variety of physiological and psychological stressors. This study was conducted to assess a rat model for in depth investigation of biochemical mechanisms and consequences of cold stress. Four groups of Sprague-Dawley rats were observed for their serum total protein, glucose, trigliceride and cholesterol levels as well as their blood pressures after housing at room temperature, administration of ADM (1.0 nm/kg), exposing to cold stress (8°C for 48 h) and exposing to ADM injection in addition to cold stress. The results suggest that application of ADM in addition to cold stress may act via receptors on different end-organs and causes altered metabolic regulation taking partial or total occupation of ADM receptors, stimulated in response to cold application induced physiologic ADM release before pharmacological ADM administration. © 2002 Elsevier Science Ireland Ltd. All rights reserved.