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Öğe Effects of Molsidomine against Doxorubicin-Induced Cardiotoxicity in Rats(Karger, 2013) Disli, O. M.; Sarihan, E.; Colak, M. C.; Vardi, N.; Polat, A.; Yagmur, J.; Tamtekin, B.Purpose: To explore the protective and curative effects of molsidomine (MOL) on doxorubicin (DOX)-induced cardiac damage in the in vivo rat heart. Methods: Forty rats were randomized into five groups (n = 8): (1) the control group; (2) the MOL group (10 mg/kg for 21 days); (3) the DOX group (a single dose of 20 mg/kg); (4) the DOX + MOL group (3 days after the single dose of DOX, 10 mg/kg MOL continued for 21 days), and (5) the MOL + DOX group (24 h after a 21-day regimen of 10 mg/kg MOL, a single dose of DOX). The rats were monitored for mean arterial blood pressure, heart rate, O-2 saturation, and electrocardiography. Heart tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and nitric oxide (NO) were determined. Results: Blood pressure and O-2 saturation values indicated a significant decrease in the DOX group compared with the control group. T negativity was observed in 4 of 8 rats in the DOX group, in 1 of 8 rats in the DOX + MOL group, and in 4 of 8 rats in the MOL + DOX group. MDA levels were significantly higher in the DOX group. SOD, GSH, and NO levels were significantly lower in the DOX group compared with the other groups. There was no statistically significant difference in the CAT levels in any of the study groups compared with controls. DOX treatment induced morphological alterations, such as disorganization of cardiomyocytes, loss of myofibrils, and cytoplasmic vacuolization in the heart. On the other hand, histological damage was significantly reduced in the DOX + MOL and MOL + DOX groups. Conclusion: This study implies that there are cardioprotective effects of MOL on DOX-induced cardiotoxicity. (C) 2013 S. Karger AG, BaselÖğe Effects of Transcatheter Closure of Atrial Septal Defects on Heart Rate Variability(Sage Publications Ltd, 2011) Cansel, M.; Yagmur, J.; Ermis, N.; Acikgoz, N.; Tasolar, H.; Atas, H.; Muezzinoglu, K.This study evaluated heart rate variability and its changes in 30 patients before and after transcatheter closure of secundum atrial septal defects. Heart rate variability data from 30 healthy volunteers with normal echocardiographic parameters and no history of atrial septal defects were included as controls. Values for the SD of all the normal RR intervals (SDNN), the SD of the means of all the 5-min segment normal RR intervals (SDANN), and the mean of all the 5-min SDs of normal RR intervals during the 24-h period (SDNN index) in patients with atrial septal defects before transcatheter closure were statistically significantly different from controls. At 6 months after closure of the defects these values were not statistically different from controls. It is concluded that transcatheter closure of secundum atrial septal defects had positive effects on heart rate variability and, consequently, may contribute to less mortality and morbidity.Öğe Fate of Untreated Pericardial Synovial Sarcoma; A Case Report(Excerpta Medica Inc-Elsevier Science Inc, 2014) Hidayet, S.; Bayramoglu, A.; Otlu, Y. O.; Yilmaz, M.; Yagmur, J.; Ozdemir, R.[Abstract Not Available]Öğe Iodide-induced parotitis after coronary angiography(Medcom Ltd, 2011) Cansel, M.; Yagmur, J.; Cuglan, B.; Tasolar, H.A 55-year-old woman with stable angina pectoris who had undergone elective coronary catheterization five years ago, no coronary artery disease had been reported at that time. Recent noninvasive stress testing was performed and the result was positive. Coronary angiography was repeated by using iodinated contrast medium. At catheterization, no angiographically significant coronary stenoses was found. About 36 hours after coronary angiography she presented to the emergency department for swelling of face and throat bilaterally. Her parotid glands were diffusely and symmetrically enlarged to twice the normal size and glands were firm and non-tender. This case had taken iodinated contrast medium before and she had the same symptoms. So she might be an example of recurrent parotitis caused by repeated iodide exposure. (Hong Kong j.emerg.med. 2011;18:421-423)Öğe A Kidney Transplant Center's Initial Experiences in Eastern Turkey(Elsevier Science Inc, 2012) Piskin, T.; Unal, B.; Koz, S.; Ulutas, O.; Yagmur, J.; Beytur, A.; Kayhan, B.Objectives. Kidney transplantation is the best treatment method associated with improved quality of life and better survival for patients with end-stage renal disease. We started performing kidney transplantations in November 2010. We have performed 19 kidney transplantations so far. Fourteen of these were from living donors and five from deceased donors. Here, we present our initial experiences with 1.4 kidney transplant recipients from living donor kidney transplantations. Materials and methods. All recipients and their donors underwent detailed clinical history and examination. Recipients and their donors were followed in the transplant clinic during hospitalization. Results. The male-to-female ratio was 11:3 in recipients. The mean age of recipients was 27.8 years (range 4-58 years). The number of the related, emotionally related, and unrelated transplantations were 9, 3, 2, respectively. The mean warm ischemic time was 95.7 seconds (range 52-1.68 seconds). Urine output started immediately after vascular anastomosis in all. The mean time of discharge from hospital was postoperative day 8 (range 4-18 days). The mean flow up was 125 days (range 18-210 days). Graft survival was 100% in this period, but one patient died from sepsis after 56 days. No kidney was lost from rejection, technical causes, infection, or recurrent disease. Conclusion. If transplant centers are as equipped and experienced as ours, kidney transplant programs should be started immediately so that they can reduce the number of the patients in waiting list for kidney transplantation.Öğe Outcomes of Kidney Transplantations From the Same Deceased Donor to Two Different Recipients: A Single-Center Experience(Elsevier Science Inc, 2017) Piskin, T.; Unal, B.; Kutluturk, K.; Yildirim, I. O.; Berktas, B.; Dogan, S. M.; Yagmur, J.Background. Kidney transplantation is the best treatment method for end-stage renal disease. Technically, left kidney transplantation is easier than right kidney, and the complication rates in the right are higher than the left kidney. We performed 28 kidney transplantations from 14 deceased donors between November 2010 and May 2016. Our aim was to share our outcomes and experiences about these 28 patients. Methods. We performed 182 kidney transplantations between November 2010 and May 2016. Fifty-four kidney transplantations were performed from deceased donors. Thirty-two of these were performed from 16 of the same donors. These 32 recipients' data were collected and, retrospectively analyzed. We excluded the transplantations from two same donors to their four recipients in this study. The remaining 28 recipients were included in the study. Results. The left and right kidney recipients' 'numbers were equal (14:14). The left kidney:right kidney rate was 11:3 in the first kidney transplantation recipient group; in the second kidney transplantation recipient group, the rate was 3:11. The difference was statistically significant (P =.002). We found no statistical differences for sex, mean age, and body mass index of recipients, total ischemic time of grafts, hospitalization times, creatinine levels at discharge time, and current ratio of postoperative complications of recipients (P >.05). Conclusions. There were no differences in the left or the right kidneys or in the first and the second kidney transplantations during the long follow-up period.Öğe P wave dispersion and atrial electromechanical delay in patients with prehypertension(Oxford Univ Press, 2010) Ermis, N.; Acikgoz, N.; Yasar, E.; Tasolar, H.; Atas, H.; Pekdemir, H.; Yagmur, J.[Abstract Not Available]Öğe SERUM GAMMA-GLUTAMYL TRANSFERASE (GGT) LEVELS AND INFLAMMATORY ACTIVITY IN PATIENTS WITH NON-DIPPER HYPERTENSION(Elsevier Ireland Ltd, 2011) Ermis, N.; Yagmur, J.; Acikgoz, N.; Cansel, M.; Cuglan, B.; Pekdemir, H.; Ozdemir, R.[Abstract Not Available]Öğe Stressor effect of zoledronic acide in rabbit heart tissue(Pergamon-Elsevier Science Ltd, 2010) Karabulut, A. Bay; Gul, M.; Yagmur, J.; Karabulut, E.; Kiran, T.[Abstract Not Available]
