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    Comparison of major coronary risk factors in female and male patients with premature coronary artery disease
    (Taylor & Francis Ltd, 2008) Yasar, Ayse Saatci; Turhan, Hasan; Basar, Nurcan; Metin, Fatma; Erbay, Ali Riza; Ilkay, Erdogan; Sabah, Irfan
    Objective -The present study was designed to analyse and compare the major coronary risk factors of female and male patients with premature coronary artery disease (CAD) aged <= 45 years. Methods - We evaluated 4613 consecutive patients who underwent coronary angiography at our institution; 572 symptomatic patients (489 men and 83 women) diagnosed as having premature CAD (age <= 45 years) were included in our analysis. For each patient, the presence of major coronary risk factors such as family history of CAD, hypercholesterolaemia, diabetes mellitus, hypertension and cigarette smoking were recorded. Besides, clinical presentation and angiographic findings were also recorded. Results - The most common risk factor was cigarette smoking in young men (70.3%). However, the major coronary risk factor was hypercholesterolaemia in young women (67.5%).When we compared two groups with respect to major coronary risk factors, we found that the prevalence of diabetes mellitus and hypertension were significantly higher in young women than in young men (diabetes mellitus: 27.7% vs. 12.3%, respectively, P < 0.001, hypertension: 56.6% vs. 23.4%, respectively, P < 0.00 1). However, cigarette smoking was found to be significantly higher in men than in women (70.3% vs. 28.9% respectively, P < 0.00 1). Conclusion - We have shown for the first time the impact of gender on the coronary risk factor profile in young Turkish patients with premature CAD.These findings may be useful for gender-based management and risk factor modification of young patients with premature CAD.
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    The impact of metabolic syndrome on left ventricular function: Evaluated by using the index of myocardial performance
    (Elsevier Ireland Ltd, 2009) Turhan, Hasan; Yasar, Ayse Saatci; Yagmur, Julide; Kurtoglu, Ertugrul; Yetkin, Ertan
    Aim: To evaluate the impact of metabolic syndrome on global left ventricular function by using the index of myocardial performance. Methods: The study population included 106 patients with metabolic syndrome (66 male, 40 female, mean age=54 +/- 11 years) and 106 control subjects without metabolic syndrome (71 male, 35 female, mean age=53 +/- 10). The diagnosis of metabolic syndrome was based on The National Cholesterol Education Program Adult Treatment Panel III criteria. All patients underwent two-dimensional and Doppler echocardiographic examination. The index of myocardial performance was determined as the sum of isovolumic relaxation time and isovolumic contraction time divided by left ventricular ejection time. Results: The index of myocardial performance was found to be significantly higher in patients with metabolic syndrome compared with control subjects without metabolic syndrome (0.55 +/- 0.06 vs 0.38 +/- 0.04 respectively, p < 0.001). Conclusion: In the present study, we have shown the presence of impaired global left ventricular function in patients with metabolic syndrome compared with control subjects without metabolic syndrome. This finding emphasizes the importance of early diagnosis and management of metabolic syndrome to prevent the progression of ventricular dysfunction to overt structural and symptomatic cardiac disease. (C) 2008 Published by Elsevier Ireland Ltd.