Yazar "Yasul, Yavuz" seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Core Exercise as Non-Pharmacological Strategy for Improving Metabolic Health in Prediabetic Women(Mdpi, 2025) Yigiter, Nuray; Akcinar, Faruk; Yasul, Yavuz; Cinar, Vedat; Akbulut, Taner; Migliaccio, Gian MarioBackground and Objectives: Prediabetes (PD) is characterized by impaired glucose metabolism and is associated with an elevated risk of type 2 diabetes and cardiovascular diseases. This study aimed to investigate the effects of an 8-week core exercise intervention on glycemic control, lipid profiles, insulin sensitivity, body composition, and physical performance in prediabetic women. Materials and Methods: Eighteen prediabetic women aged 20-55 years were randomly allocated to either a core exercise group (n = 9) or a control group (n = 9). The intervention group completed 24 supervised core exercise sessions over 8 weeks, whereas the control group remained sedentary. Pre- and post-intervention evaluations included anthropometric measurements, flexibility and strength tests, fasting and postprandial glucose levels, HbA1c, insulin, HOMA-IR, lipid profiles, and serum iron levels. Non-parametric tests were used for statistical analysis, and a Principal Component Analysis (PCA) and hierarchical clustering were conducted to explore multidimensional metabolic changes. Results: Core exercise significantly improved the body weight, BMI, fat percentage, and circumferences (shoulder, chest, and hip), along with an enhanced flexibility and back-leg strength (p < 0.05). Glycemic indices (FBG, PBG, and HbA1c), insulin, and HOMA-IR levels were significantly reduced, while serum iron and HDL-C increased (p < 0.05). Lipid markers, including the TG, LDL-C, CHOL, and TG/HDL-C ratio, showed significant improvements. The PCA and cluster analyses identified three clusters reflecting metabolic risk, body composition, and protective factors. Conclusions: This study demonstrates that an 8-week structured core exercise program significantly improves glycemic control, lipid profiles, insulin sensitivity, and body composition in women with prediabetes. Multivariate analyses (PCA and hierarchical clustering) corroborate a metabolic shift towards a reduced insulin resistance and a more favorable cardiometabolic profile, supporting core training as a viable, evidence-based non-pharmacological intervention to mitigate metabolic risk.Öğe Effects of short-term pre-competition weight loss on certain physiological parameters and strength change in elite boxers(Public Library Science, 2024) Yasul, Yavuz; Akcinar, Faruk; Yasul, Muhammet Enes; Kurtoglu, Ahmet; Eken, Ozgur; Badicu, Georgian; Ardigo, Luca PaoloBackground Athletes in certain sports aim to gain an advantage by competing in a lower body mass class instead of competing in their own body mass class. This study aims to reveal certain physiologic and strength changes in elite male boxers who lost body mass rapidly before the competition.Methods 30 thirty boxers who were aged between 19-24 years and having a mean age of 7.4 years participated in the study. To evaluate the effect of short-term dietary intake interventions on body composition and muscle strength before the competition, boxers were divided into three groups: control (C), exercise+diet1 (E+D1) and exercise+diet2 (E+D2) groups. The dietary habits of the participants were controlled and they participated in the training program. The data of the study consisted of variables such as body mass, height, regional muscle mass, body fat percentage, biceps and femur bicondylar circumference measurements before the competitions. Isometric strength measurements of knee extensors and flexors and shoulder internal and external rotators were also recorded.Results Physiologic parameters such as body mass change, BMI level, body fat percentage and leg muscle ratios of E+D2 were significantly decreased compared to C and E+D1 groups. Furthermore, submaximal and maximal strength production in knee extensors and flexors as well as shoulder internal and external rotators were significantly decreased in E+D2 compared to C and E+D1 groups.Conclusion The tendency to lose body mass quickly in a short of time may give the desired results in terms of BMI, body mass and fat percentage, but it may cause strength losses in boxers during the competition period.Öğe Farklı egzersizler uygulanan ratlarda koenzim Q10 takviyesinin serum, kalp kası ve iskelet kaslarinda tümstatin ekpresyonlarına ve lipit profiline etkisi(İnönü Üniversitesi, 2021) Yasul, Yavuz; Akçınar, Faruk; Çinar, VedatAmaç: Bu çalışma sıçanlara koenzim Q10 (CoQ10) takviyesi ile birlikte uygulanan farklı yoğunluktaki egzersizlerin tümstatin ekpresyon düzeyleri ve sıçan lipit profili üzerine etkisini belirlemek amacıyla yapılmıştır. Materyal ve Metot: Yapılan deneysel çalışmada 42 adet 8 haftalık erişkin Wistar albino ırkı erkek sıçan kullanıldı. Sıçanlar rastgele kontrol, CoQ10 takviye, aerobik ve anaerobik egzersiz, aerobik CoQ10, anaerobik CoQ10 takviye+egzersiz şeklinde 6 gruba ayrıldı. Tüm gruplar (kontrol ve CoQ10 grubu hariç) ilk haftayı koşu bandına ve egzersiz protokolüne hazırlık evresi olarak geçirdi. CoQ10 takviyesi gavaj yöntemi ile verildi. Tüm sıçanlara ait serum örnekleri, iskelet ve kalp kası dokuları -80 ?C'de muhafaza edildi ve tümstatin seviyeleri ELISA yöntemiyle tespit edildi. Histolojik çalışmalar için ise sıçanlardan alınan iskelet ve kalp kası dokuları formaldehitte tespit edildi ve takip serilerinden geçirilerek parafin bloklara gömüldü. Parafin bloklardan mikrotom ile 5-6 µm kalınlığında kesitler alındı ve alınan kesitler immünohistokimya metodu ile boyandı. Boyanan preparatlar araştırma mikroskobunda incelendi ve fotoğraflandı. Bulgular: Çalışmanın sonunda sıçan canlı ağırlıkları, serum HDL, VLDL, trigliserit ve kolesterol seviyeleri gruplar arasında anlamlı düzeyde farklıydı. Yine kalp ve iskelet kası homojenatlarındaki tümstatin seviyelerinde gruplar arasında anlamlı farklılıklar izlendi. Bu farklılıklar immünohistokimya metodu ile boyanan preparatlar tarafından desteklendi. Sonuç: Çalışmada, egzersiz yoğunluğu ve CoQ10 takviyesi lipit profilini önemli düzeyde etkileyerek HDL, VLDL, trigliserit ve kolesterol seviyelerini iyileştirdiği gözlemlendi. Ayrıca egzersiz yoğunluğu ve CoQ10 takviyesi tümstatin salınım düzeyini de etkiledi. Dolayısıyla bu etki kalp ve iskelet kasında anjiyogenezi yeniden modelledi.Öğe Investigation of Iris, Leptin, Ghreline and Some Hormonal Responses of the Strength Training Program Applied to Handball Players(Lahore Medical Research Center Llp, 2021) Turgut, Mine; Cinar, Fidan; Dundar, Aykut; Yasul, Yavuz; Cinar, Vedat; Yamaner, Yusuf BurakBackground: The effects of exercise on physiological systems were an inevitable truth. Especially the relationship of exercise with the endocrine system was one of the important focuses of interest. Irisin, Seratonin, Melatonin, Leptin, Ghrelin and Apelin hormones, which become a ball of interest recently, were the subjects that researchers follow and work with great interest. Aim: This study aimed to determine the effect of strength training program applied to handball players on the Irisin, Seratonin, Melatonin, Leptin, Ghrelin and Apelin hormones. Method: 24 healthy male handball players between the ages of 18-24 participated in the study. Participants were randomly divided into two groups (control and experimental). While handball training was applied to the first group (control) for 6 weeks, strength training was applied to the second group (experimental). The blood samples of the participants were taken on an empty stomach in the morning by experts in the appropriate laboratory environment before the training at rest, according to the pre-test and post-test model. In the analysis of the data, descriptive statistics (mean, standard deviation) and Shapiro Wilk test, kurtosis, steepness and histogram graph were taken into consideration to test the normality of the distribution before starting the analysis, and it was observed that the distribution was normal. In this context, Paired Samples t-test was used to reveal intra-group differences and the Independent samples t-test statistical techniques were used to reveal differences between groups. The level of significance was set at 0.05 and the analyses were made in the Windows SPSS 22 package program. Results: It was observed that irisin, apelin and ghrelin levels increased in the experimental group of the strength training program applied with the obtained results, it did not change in the control group. It was determined that the serotonin level increased in both the strength training group and the control group. While it was observed that the leptin level decreased in the Strength group, it did not change in the control group, and it was understood that the melatonin level did not undergo any change in both the experimental and control groups. Conclusion: As a result, it was concluded that the 6-week strength training protocol applied to athletes caused significant changes in irisin, apelin, ghrelin, serotonin, leptin levels of handball players, but did not show any change in melatonin levels.Öğe Moderate/High-Intensity Exercise and Coenzyme Q10 Supplementation May Reduce Tumstatin and Improve the Lipid Dynamics and Body Mass in Rats(Mdpi, 2025) Yasul, Yavuz; Akcinar, Faruk; Cinar, Vedat; Akbulut, Taner; Aydemir, Isa; Yalcin, Mehmet Hanifi; Avcu, Emsal caglaCoenzyme Q(10) (CoQ(10)) is a molecule that serves as a coenzyme for mitochondrial enzymes, playing a fundamental role in mitochondrial bioenergetics as an electron and proton carrier in the energy production process. This study aimed to examine the modulatory effects of moderate/high-intensity exercise and CoQ(10) supplementation on tumstatin, lipid dynamics, and body mass in rats. This study used 42 male Wistar Albino rats in six groups: a control group (C), a moderate-intensity continuous training group (MICT), a high-intensity continuous training group (HICT), a coenzyme Q(10) group (Q(10)), a moderate-intensity continuous training combined with Q(10) group (MICTQ(10)), and a high-intensity continuous training combined with Q(10) group (HICTQ(10)) to assess the effects of exercise and 5 mg/kg/daily CoQ(10) supplementation. Rats underwent treadmill training, and tumstatin levels in plasma, cardiac, and skeletal muscle tissues were measured using ELISA and immunostaining techniques. In addition to the plasma, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC) levels were analyzed using enzymatic methods, with the LDL-C calculated using the Friedewald equation. The atherogenic index of plasma was determined by the TG/HDL-C ratio. As compared to group C, body mass was significantly affected by both exercise intensity and supplementation (p = 0.01, eta(2) = 0.37), with the MICTQ(10) and HICTQ(10) groups demonstrating the greatest reductions by day 50th (p = 0.0003, d = 4.02; p = 0.0001, d = 3.99). Lipid profiles varied significantly between groups. Compared to the C group, the MICTQ(10) group exhibited the most substantial decreases in LDL-C (p = 0.03, d = 2.35) and TG levels (p = 0.03, d = 2.25), while the HICTQ(10) group showed the most pronounced reduction in TC levels (p = 0.001, d = 6.41). Regarding tumstatin levels, skeletal muscle tumstatin levels were lowest in the HICTQ(10) group (p = 0.01, d = 2.11). Moreover, cardiac muscle tumstatin levels were significantly lower in the MICTQ(10), MICT, and HICTQ(10) groups compared to in the C group (p = 0.004, d = 1.01). These findings suggest that both exercise intensity and CoQ(10) supplementation exert notable physiological effects, particularly in modulating body mass, lipid metabolism, and tumstatin levels.
