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    Antenatal Magnesium Sulfate Use for Fetal Neuroprotection: Experience from a Tertiary Care Hospital in Turkey
    (Allied Acad, 2017) Rauf, Melekoglu; Sevil, Eraslan; Ebru, Celik; Yavuz, Simsek; Cemil, Colak
    Aims: We aimed to demonstrate the effect of magnesium sulfate for fetal neuroprotection on maternal and neonatal outcomes of pregnants delivered before 32 weeks. Materials and methods: The records of 107 patients who were delivered before 32 weeks of pregnancy were reviewed retrospectively during the period between January 2011-February 2016. Patients who were treated with MgSO4 for fetal neuroprotective effect constituted the study group, and patients who were not received MgSO4 for the fetal neuroprotection represented the control group. Results: One hundred seven women delivered before 32nd weeks of pregnancy met study criteria and of these patients, 46 were formed the magnesium sulfate group, and the remaining 61 were constituted the control group. The age (28.37 +/- 4.97 versus 29.90 +/- 5.23 respectively; p= 0.129), body mass index (BMI) (26.25 +/- 4.12 versus 26.90 +/- 5.68 respectively; p= 0.342) and gestational age at delivery (28.08 +/- 2.66 versus 28.78 +/- 2.15 respectively; p= 0.136) were similar between the groups. Intraventricular hemorrhage was more common in control group compared with the MgSO4 group [7/61 (11.4%) versus 3/46 (6.5%); p= 0.049]. For the periventricular leukomalacia [1 (2.2%) versus 0 (0%) respectively; p= 0.430], neonatal convulsion [1 (2.2%) versus 3 (4.9%) respectively; P= 0.630] and neonatal encephalopathy [0 (0%) versus 1 (1.6%) respectively; p= 0.570], no substantial differences were seen between the groups. Conclusions: The results of this study suggest that MgSO4 treatment for fetal neuroprotection has a beneficial effect on intraventricular hemorrhage rate. The widespread use of prenatal MgSO4 for the purpose of fetal neuroprotection before 32 weeks of pregnancy at a standard dose protocol could improve the neonatal neurological outcomes.
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    Antenatal magnesium sulfate use for fetal neuroprotection: experience from a tertiary care hospitalin turkey
    (Allıed acad, 40 bloomsbury way, lower ground flr, london, wc1a 2se, england, 2017) Rauf, Melekoglu; Sevil, Eraslan; Ebru, Celik; Yavuz, Simsek; Cemil, Colak
    Aims: We aimed to demonstrate the effect of magnesium sulfate for fetal neuroprotection on maternal and neonatal outcomes of pregnants delivered before 32 weeks. Materials and methods: The records of 107 patients who were delivered before 32 weeks of pregnancy were reviewed retrospectively during the period between January 2011-February 2016. Patients who were treated with MgSO4 for fetal neuroprotective effect constituted the study group, and patients who were not received MgSO4 for the fetal neuroprotection represented the control group. Results: One hundred seven women delivered before 32nd weeks of pregnancy met study criteria and of these patients, 46 were formed the magnesium sulfate group, and the remaining 61 were constituted the control group. The age (28.37 +/- 4.97 versus 29.90 +/- 5.23 respectively; p= 0.129), body mass index (BMI) (26.25 +/- 4.12 versus 26.90 +/- 5.68 respectively; p= 0.342) and gestational age at delivery (28.08 +/- 2.66 versus 28.78 +/- 2.15 respectively; p= 0.136) were similar between the groups. Intraventricular hemorrhage was more common in control group compared with the MgSO4 group [7/61 (11.4%) versus 3/46 (6.5%); p= 0.049]. For the periventricular leukomalacia [1 (2.2%) versus 0 (0%) respectively; p= 0.430], neonatal convulsion [1 (2.2%) versus 3 (4.9%) respectively; P= 0.630] and neonatal encephalopathy [0 (0%) versus 1 (1.6%) respectively; p= 0.570], no substantial differences were seen between the groups. Conclusions: The results of this study suggest that MgSO4 treatment for fetal neuroprotection has a beneficial effect on intraventricular hemorrhage rate. The widespread use of prenatal MgSO4 for the purpose of fetal neuroprotection before 32 weeks of pregnancy at a standard dose protocol could improve the neonatal neurological outcomes.
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    Resveratrol successfully treats experimental endometriosis through modulation of oxidative stress and lipid peroxidation
    (Wolters Kluwer Medknow Publications, 2014) Yavuz, Simsek; Aydin, Nasuhi E.; Celik, O.; Yilmaz, E.; Ozerol, E.; Tanbek, K.
    Background and Aims: The purpose of this study was to investigate the potential therapeutic efficiency of resveratrol in the treatment of experimental endometriosis in rats. Settings and Design: Experimental study was carried out in a University hospital. Materials and Methods: Endometriosis was surgically induced in 24 female rats. Four weeks after this procedure, the viability and dimensions of the endometriosis foci were recorded. Rats were then randomly divided into three groups: (1) Control group (n = 8); (2) low dose (10 mg/kg) resveratrol group (n = 8); (3) high dose (100 mg/kg) resveratrol group (n = 8). At the end of the 7-day treatment, blood samples were taken and laparotomy was performed. The endometrial implants were processed for biochemical, histological and immunohistochemical studies. Statistical Analysis Used: The Kruskal-Wallis H test and one-way ANOVA test were used. Results: Resveratrol-treated rats showed significantly reduced endometriotic implant volumes (P = 0.004). After treatment, a significant and dose-dependent increase in activities of superoxide dismutase and glutathione peroxidase in serum and tissue of the rats in Group 2 and Group 3 was detected. Similarly, serum and tissue malonyl dialdehyde levels and tissue catalase levels were significantly higher in Group 3 than that of control animals. Histological scores and proliferating cell nuclear antigen expression levels were also significantly reduced in Group 2 and Group 3 than that of control group. Conclusion: In a rat endometriosis model, resveratrol showed potential ameliorative effects on endometriotic implants probably due to its potent antioxidative properties.