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    Determination factors of affecting the risks of non-recovery in cutaneous leishmaniasis patients using binary logistic regression
    (2018) Aksoy, Mustafa; Yesilova, Abdullah; Yesilova, Yavuz; An, Isa
    Aim: This article aimed to make an assessment by applying the binary logistic regression from the studies reported for cutaneous leishmaniasis patients in the province of Şanlıurfa. Material and Methods: The age and sex, the type, localization, diameter and number of lesions as well as treatments of 8000 cutaneous leishmaniasis patients were retrospectively recorded in this study. The risk of non-recovery for intralesional (IL) and intramuscular (IM) groups according to independent variables were assessed using a binary logistic regression. Results: While there was no difference in non-recuperation risk of IL group between genders, males were 39.4% more likely to recuperate than females among the patients belonging to IM groups. All age groups, non-recuperation risk of children were decreased according to the reference level in IL group. As for the IM treatment, non-recovery risk was considered statistically insignificant. During the disease of the patients receiving both IL and IM treatments, non-recuperation risk of the patients of all-week groups was high according to the reference level. When the head and neck region was taken as reference level, the regions with the highest nonrecuperation risk of the lesion for IL and IM was identified as generalized and trunk, respectively. Conclusions: The treatment success rate is inversely proportional with the lesion duration in both IL and IM treatments. There was decreasing in the success rates of both treatments as a result of an increased in lesion size. Increased lesion diameter results in decreased success rates with both treatments.
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    The frequency of laryngeal involvement in lipoid proteinosis patients
    (2019) Aksoy, Mustafa; Yukkaldiran, Ahmet; Yesilova, Yavuz; Demir, Mahmut; Iynen, Ismail; An, Isa; Tanrikulu, Osman
    Aim: Lipoid proteinosis (LP) is a rare autosomal recessive disorder that occurs with the accumulation of hyaline substance in oral cavity, laryngeal mucosa and skin. The aim of this study was to investigate the incidence of laryngeal involvement in patients with LP which have hoarseness and skin lesions, and the areas of hyaline substance accumulation in the larynx. Material and Methods: In this study, 21 patients who were admitted to our Dermatology outpatient clinic between January 2013 and December 2017 and diagnosed as LP with punch biopsy were evaluated. Laryngeal imaging was performed in otorhinolaryngology clinic, and the frequency of larynx involvement and the areas of hyaline accumulation in the larynx were evaluated. Results: Twenty-one patients with hoarseness and diagnosed by skin biopsy as LP were included in the study. Thickening of the vocal cords in 21 patients (100%); thickening and hypertrophic changes of arytenoids in 13 patients (61.9%); thickening and hypertrophic changes of the interarytenoid area in 10 patients (47.6%); thickeningand hypertrophic changes of epiglottis in 3 (14.3%) patients; hypertrophic changes and thickening of the aryepiglottic fold in 3 patients (14.3%); thickening and hypertrophic changes of ventricular folds in 2 patients (9.5%) were observed. Conclusion: In our study, similar to the data in the literature, the pathological changes were most frequently seen in the vocal cords and the least in the ventricle band, aryepiglottic fold and epiglottis. In order to better understand the laryngeal involvement and the areas of involvement in LP patients, studies with more patients are needed.