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Öğe Aneurismal disease of different vascular territories: Is it a rare association?(Elsevier Ireland Ltd, 2005) Yetkin, E; Yetkin, G; Turhan, H[Abstract Not Available]Öğe Changes in antibody titers against Chlamydia pneumoniae after coronary angioplasty(Elsevier Ireland Ltd, 2004) Yetkin, G; Yetkin, E; Aksoy, Y; Gurbuz, OA; Mert, AObjectives: The potential role of common infectious agents in the pathogenesis and progression of atherosclerosis has been studied increasingly over the last decade. The evidence for Chlamydia pneumoniae as a potential causative agent is strong and is based on the findings of numerous sero-epidemiological studies, examination of atheromatous plaque specimens, in vitro animal models. We performed a prospective study in percutaneous transluminal coronary angioplasty (PTCA) patients to investigate whether the angioplasty procedure influenced the specific humoral immune response reaction against C. pneumoniae antigens. Methods: We studied 76 patients who successfully underwent PTCA for de novo lesions. Blood samples were drawn immediately before PTCA and 1 month after PTCA. IgG and IgA antibodies against C. pneumoniae (strain CDC/CY&-029) were determined by an in-house developed enzyme inummoassay. Results: At the time of angioplasty 75% and 34% of the patients had seropositive antibodies to elementary bodies (EBs) of classes IgG and IgA, respectively. Mean titers of IgG antibodies before and I month after PTCA were 46 +/- 31 and 50 +/- 28 relative units (RU/ml) (P > 0.05). One month after PTCA, 97% and 34% of the patients had seropositive antibodies to EBs of classes IgG and IgA, respectively. We divided our patients into two groups on the basis of IgG seropositivity (group I: Chlamydia antibody IgG seronegative patients, group II: Chlamydia antibody IgG seropositive) before PTCA. Significant increase in the antibody titers of IgG (12 5 vs. 40 18, P < 0.001) and IgA (0.6 +/- 0.33 vs. 1.15 +/- 0.83, P = 0.007) was observed in group I patients 1 month after PTCA and 88% of them gained IgG seropositivity. There were no significant changes in IgG and IgA antibody levels in group II after PTCA. Conclusion: We have demonstrated a statistically significant rise in C. pneumoniae antibodies (especially IgG) induced by PTCA in patients previously seronegative. (C) 2003 Elsevier Ireland Ltd. All rights reserved.Öğe Changes in antibody titers against chlamydia pneumoniae after percutaneous transluminal coronary angioplasty(W B Saunders Co Ltd, 2002) Yetkin, G; Yetkin, E; Aksoy, Y; Ileri, M; Mert, A; Cehreli, S[Abstract Not Available]Öğe Changes in plasma levels of adhesion molecules after percutaneous mitral balloon valvuloplasty(Elsevier Science Inc, 2004) Yetkin, E; Erbay, AR; Turhan, H; Balci, M; Yetkin, F; Yetkin, G; Ileri, MBackground: Adhesion molecules are expressed on vascular endothelium and on immune and inflammatory cells. Recently increased levels of adhesion molecules have been shown in patients with rheumatic mitral stenosis. This study examined the serum levels of the adhesion molecules intercellular adhesion molecule I (ICAM-1), vascular cell adhesion molecule I (VCAM-1), and E-selectin in patients with rheumatic mitral stenosis and the effects of percutaneous mitral balloon valvuloplasty (PMBV) on these adhesion molecules. Materials and methods: Thirty five patients (3 men, 32 women, mean age 39 5 years) with severe rheumatic mitral stenosis who underwent percutaneous balloon mitral valvuloplasty, and 35 age and sex matched healthy control subjects were included in the study. Serum levels of ICAM-1, VCAM-I, and E-selectin were measured in all patients who underwent PMBV and in all control subjects. Blood samples were taken for measurement of adhesion molecules immediately before and 24 h after the mitral balloon valvuloplasty. Results: The plasma levels of soluble adhesion molecules E-selectin, ICAM-I and VCAM-I were significantly elevated in patients with mitral stenosis compared to control subjects: E-selectin, 97 +/- 59 vs. 45 +/- 24 ng/ml (P=.001), sICAM-1, 874 +/- 301 ng/ml vs. 238 82 ng/ml (P<.0001); sVCAM-1, 3056 +/- 763 ng/ml vs. 985 +/- 298 ng/ml (P<.0001). Plasma levels of VCAM-1 significantly increased 24 h after the valvuloplasty procedure (3056 +/- 763 ng/ml vs. 3570 +/- 1225 ng/ml P=.013). Plasma levels of E-selectin showed a significant decrease after PMBV (97 +/- 59 vs. 70 +/- 58 ng/ml, P=.043) and plasma levels of ICAM-I did not show any change after PMBV (874 +/- 301 vs. 944 +/- 3 77 ng/ml, P=.356). Conclusion: Cellular adhesion molecules, sICAM-1, E-selectin, sVCAM-1 have shown changes in different directions in response to PMBV These results necessitate further studies to clarify the mechanism underlying the association between adhesion molecules and PMBV as well as rheumatic mitral stenosis. (C) 2004 Elsevier Inc. All rights reserved.Öğe Detection of Chlamydia pneumoniae deoxyribonucleic acid in blood samples taken from coronary sinus after coronary angioplasty(Excerpta Medica Inc-Elsevier Science Inc, 2002) Yetkin, E; Yetkin, G; Tandogan, I; Kocabas, NA; Ileri, M; Ozdemir, R; Kosar, FChlamydia pneumoniae deoxyribonucleic acid was not found in blood samples (0%) taken from the coronary sinus immediately before coronary angioplasty, but C. pneumoniae deoxyribonucleic acid was detected in 4 of 14 patients' blood samples (29%) taken after coronary angioplasty. This finding suggests that coronary angioplasty can cause C. pneumoniae bacteremia.Öğe Detection of Chlamydia pneumoniae DNA in blood samples taken from coronary sinus after coronary angioplasty(W B Saunders Co Ltd, 2001) Yetkin, E; Yetkin, G; Tandogan, I; Aygun, N; Ileri, M; Cehreli, S; Mert, A[Abstract Not Available]Öğe Effect of coronary angioplasty on Helicobacter pylori IgG antibody(Elsevier Ireland Ltd, 2005) Yetkin, G; Ozerol, IH; Erbay, AR; Durmaz, R[Abstract Not Available]Öğe Plasma soluble adhesion molecules; intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin levels in patients with isolated coronary artery ectasia(Lippincott Williams & Wilkins, 2005) Turhan, H; Erbay, AR; Yasar, AS; Aksoy, Y; Bicer, A; Yetkin, G; Yetkin, EPlasma soluble adhesion molecules, intercellular adhesion molecule-1 (ICAM)-1, vascular cell adhesion molecule-1 (VCAM-1) and E-selectin leves of patients with isolated coronary artery ectasia (CAE), patients with obstructive coronary artery disease without CAE and subjects with angiographically normal coronary arteries were evaluated. Patients with isolated CAE were detected to have significantly higher levels of plasma soluble ICAM-1, VCAM-1 and E-selectin in comparison with patients with obstructive coronary artery disease without CAE OCAM, 673 153 versus 381 +/- 106, respectively, P < 0.001; VCAM-1, 2366 +/- 925 versus 1136 +/- 208, respectively, P < 0.001; E-selectin, 74 +/- 21 versus 61 +/- 18, respectively, P = 0.01) and subjects with normal coronary arteries (ICAM-1, 673 +/- 153 versus 303 +/- 131, respectively, P < 0.001; VCAM-1, 2366 925 versus 729 231, respectively, P < 0.001; E-selectin, 74 +/- 21 versus 49 +/- 9, respectively, P < 0.001), suggesting the presence of a more severe and extensive chronic inflammation in the coronary circulation in patients with isolated CAE. \ Background The common coexistence of coronary artery ectasia (CAE) with coronary artery disease (CAD) suggests that it may be a variant of CAD. However, it is not clear why some patients with obstructive CAD develop CAE whereas most do not. inflammation has been reported to be a major contributing factor to both obstructive and aneurysmatic vascular disorders and therefore, in the present study, the plasma soluble adhesion molecules, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin levels in isolated CAE were investigated. Methods The study population consisted of three groups: the first consisted of 32 patients with isolated CAE without stenotic lesion; the second of 32 patients with obstructive CAD without CAE; and the third group of 30 control subjects with normal coronary arteries. Coronary diameters were measured as the maximum diameter of the ectasic segment by use of a computerized quantitative coronary angiography analysis system. According to the angiographic definition used in the Coronary Artery Surgery Study, a vessel is considered to be ectasic when its diameter is greater than or equal to 1.5 times that of the adjacent normal segment in segmental ectasia. Plasma soluble ICAM-1, VCAM-1 and E-selectin levels were measured in all patients and control subjects using commercially available enzyme-linked immunosorbent assay kits. Results Patients with isolated CAE were found to have significantly higher levels of plasma soluble ICAM-1, VCAM-1, and E-selectin in comparison with patients with obstructive CAD without CAE (ICAM, 673 +/- 153 versus 381 +/- 106, respectively; P < 0.001; VCAM-1, 2366 +/- 925 versus 1136 +/- 208, respectively; P < 0.001; E-selectin, 74 +/- 21 versus 61 +/- 18, respectively; P = 0.01) and control subjects with normal coronary arteries (ICAM-1, 673 +/- 153 versus 303 +/- 131, respectively;, P < 0.001; VCAM-1, 2366 +/- 925 versus 729 +/- 231, respectively; P < 0.001; E-selectin, 74 +/- 21 versus 49 +/- 9, respectively; P < 0.001). In addition, we detected statistically significant positive correlation between the total length of ectasic segments and the levels of plasma soluble ICAM-1 (r=0.625; P < 0.001), VCAM-1 (r= 0.548; P= 0.001) and E-selectin (r=0.390; P=0.027). Multivariate logistic regression analysis revealed a significant independent relation between isolated CAE and ICAM-1 [odds ratio (OR)= 1.023; 95% confidence interval (CI) = 1.0048-1.0414; P= 0.0129] and VCAM-1 (OR = 1.0057; 95% Cl = 1.0007-1.0106; P= 0.0240). Conclusions We have shown that patients with isolated CAE have raised levels of plasma soluble ICAM-1, VCAM-1 and E-selectin in comparison with patients with obstructive CAD without CAE and control subjects with normal coronary arteries, suggesting the presence of a more severe and extensive chronic inflammation in the coronary circulation in these patients. (C) 2005 Lippincott Williams Wilkins.Öğe An unusual case of pericarditis caused by Cardiobacterium hominis(W B Saunders Co Ltd, 2005) Kuzucu, C; Yetkin, G; Kocak, G; Nisanoglu, V[Abstract Not Available]
