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Öğe Adequate use of pulmonary embolism clinical prediction rule in COPD patients(European Respiratory Soc Journals Ltd, 2011) Gunen, H.; Gulbas, G.; In, E.; Yetkin, O.; Hacievliyagil, S. S.[Abstract Not Available]Öğe Assessment of B-type natriuretic peptide in patients with pneumonia(Wiley, 2008) Yetkin, O.; Hacievliyagil, S. S.; Gunen, H.The mammalian heart synthesises and secretes B-type natriuretic peptide (BNP), which has potent diuretic, natriuretic and vascular smooth muscle-relaxing effects as well as complex interactions with the hormonal and nervous systems. Recent studies described that BNP was acute phase reactant. In this study, we aimed to evaluate BNP levels in patients with pneumonia. Twenty-one patients with pneumonia and 21 healthy control subjects were enrolled in this study. Their serum levels of BNP were measured in addition to the standard evaluations. Leucocyte count [19.3 (13.2-25.7) 10(6)/Ml VS. 9.55 (3.7-13.9) 106/Ml, p < 0.0011, erythrocyte sedimentation rate [73 (57-81) mm/h vs. 35 (4-55) mm/h, p < 0.001], C-reactive protein (CRP) [127.72 (27-290) mg/l vs. 13.19 (3-41) mg/l, p < 0.0011 and BNP [53.1 (17-91) pg/ml vs. 16.24 (1-38) pg/ml, p < 0.0011 levels significantly decreased after treatment period. Initial BNP levels were significantly higher than control groups (53.10 +/- 15.07 pg/ml vs. 18.62 +/- 14.05 pg/ml, p < 0.001) and decreased after treatment to the levels comparable with control subjects. BNP levels correlated with CRP levels at admission (r = 0.716, p < 0.001). We have shown that BNP levels show a transient increase in patients with pneumonia and correlate well with CRP.Öğe Effect Of Long Term Oxygen Therapy On Energy Metabolism In Patient With COPD(Amer Thoracic Soc, 2014) Yetkin, O.; Berber, N. K.; Tavli, D.; Geckil, A.; Turan, G.[Abstract Not Available]Öğe The effects of N-acetylcysteine on pulmonary functions in patients undergoing on-pump coronary artery surgery: a double blind placebo controlled study(Verduci Publisher, 2016) Erdil, N.; Eroglu, T.; Akca, B.; Disli, O. M.; Yetkin, O.; Colak, M. C.; Erdil, F.OBJECTIVE: To investigate the effects of N-acetylcysteine (NAC) on pulmonary function tests and arterial blood gases in patients undergoing on-pump coronary artery surgery. PATIENTS AND METHODS: The effect of NAC was assessed within the scope of a prospective, single center, double-blind, placebo-controlled, parallel group study. Eighty-two patients undergoing coronary artery bypass grafting were randomized into two groups to receive either placebo (group 1, n = 40) or NAC (group 2, n=42). Both the NAC group and the placebo-receiving control group also included a COPD subgroup consisting of patients with an FEV1/FVC ratio of < 0.7 and an FEV1 value of 50-80%. Pulmonary function tests were performed preoperatively and on postoperative day 60. RESULTS: Both groups were similar with respect to age, gender, preoperative risk factors, ejection fraction (EF), mean cross-clamp time, ventilation time, intensive care unit (ICU) stay, atrial fibrillation (AF) and hospital stay (p > 0.05). Postoperative FVC and FEV1 values in group 1 and the postoperative FEV1, FEV1/FVC and FEF 25-75 values in group 2 were lower in comparison to their preoperative values. However, in both group 1 and 2, the decreases observed in these parameters were not statistically significant (p > 0.05). In the COPD subgroup of group 1, a postoperative decrease was observed in the FEV1 and FEF25-75 values, with the FEV1 decreasing by 4.55%, and the FEF25-75 decreasing by 4.2% (p < 0.05). In the COPD subgroup of group 2, no significant decrease was observed in the pulmonary function test values (p > 0.05). CONCLUSIONS: This study demonstrated that NAC administration in COPD patients undergoing on-pump coronary artery surgery resulted in the preservation of pulmonary functions.Öğe Meaning Of Sleep Spindles In Patients With Obstructive Sleep Apnea(Amer Thoracic Soc, 2013) Yetkin, O.; Tavli, D. A.; Berber, N. K.; Geckin, A. A.[Abstract Not Available]Öğe Serum Syndechan-1 Levels in Patients with Nonsmall Cell Lung Cancer(Elsevıer scıence ınc, 360 park ave south, new york, ny 10010-1710 usa, 2018) Tek, I.; Yetkin, O.; Yetkin, G.; Iraz, M.Öğe Serum Syndechan-1 Levels in Patients with Nonsmall Cell Lung Cancer(Elsevier Science Inc, 2018) Tek, I.; Yetkin, O.; Yetkin, G.; Iraz, M.[Abstract Not Available]Öğe Venous thromboemboli and exacerbations of COPD(European Respiratory Soc Journals Ltd, 2010) Gunen, H.; Gulbas, G.; In, E.; Yetkin, O.; Hacievliyagil, S. S.The aim of the present study was to determine the prevalence of and risk factors for venous thromboembolism (VTE) in exacerbations of chronic obstructive pulmonary disease (COPD). COPD patients hospitalised with an exacerbation were included consecutively. Symptoms, signs and clinical, haematological and epidemiological parameters on admission were noted. All patients underwent computed tomographic angiography and ultrasonographic examination for deep vein thrombosis and pulmonary embolism (PE). Wells and Geneva scores were calculated. Patients were followed-up for 1 yr in order to determine mortality. Deep vein thrombosis and PE were detected in 14 and 18 patients, respectively. The prevalence of VTE was three times higher in patients with an exacerbation of unknown origin than in patients with an exacerbation of known origin (p=0.016). Of patients with VTE, 20 (95%) had high D-dimer levels. The negative predictive value of D-dimer testing was 0.98. Although the moderate-and high-risk categories of both the Wells and Geneva methods covered all PE patients, the Wells method identified 49% less potential patients for PE investigation. Mortality at 1 yr was higher (61.9% versus 31.8%) in VTE patients (p=0.013). VTE is a common problem in COPD patients hospitalised with an exacerbation, leading to high long-term mortality. D-dimer levels and the Wells criteria can be used to determine whether or not these patients are assessed for a thromboembolic event.
