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    Chronic granulomatous disease; Three different clinical presentation
    (2017) Celiksoy, Mehmet Halil; Koker, Mustafa Yavuz; Sensoy, Gulnar; Ceyhan, Meltem; Belet, Nursen; Yildiran, Alisan
    Chronic granulomatous disease is an inherited disorder of nicotinamide-adenine dinucleotide phosphate oxidase and results in a defect in intracellular killing of ingested microorganisms characterized by recurrent life threatening bacterial and fungal infections. The disease is classified by mutations in specific subunits of the NADPH oxidase enzyme. There are one X-linked and four autosomal recessive forms of disease. The organisms cultured from lesion of patients with chronic granulomatous disease are generally catalase-producing including Staphylococci, Escherichia coli, Serratia; or fungi such as Aspergillus species. Recurrent or serious infections usually lead to diagnosis of disease in early childhood. We report three male patients who were diagnosed 5, 10, 13 years old, respectively and showed different clinical presentation.
  • Küçük Resim Yok
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    COMPARISON OF PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS AND RECENT THYMIC EMIGRANTS IN PATIENTS WITH ATAXIA TELANGIECTASIA AND AGE-MATCHED HEALTHY CHILDREN
    (Springer/Plenum Publishers, 2014) Celiksoy, Mehmet Halil; Topal, Erdem; Yildiran, Alisan
    [Abstract Not Available]
  • Küçük Resim Yok
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    Potential Effects of Stem Cells Derived from the Peripheral Nerve and Adipose Tissue after the Nerve Crush Injury in Control and Obese Rats
    (Taylor & Francis Inc, 2022) Kustepe, Elif Kayhan; Altunkaynak, Berrin Zuhal; Alkan, Isinsu; Kivrak, Elfide Gizem; Yildiran, Alisan; Geuna, Stefano
    Aim of this study is to investigate effects of stem cells derived from the peripheral nerve and adipose tissues following the nerve crush injury in control and obese rats. For this aim, 41 Wistar Albino female rats were separated into eight equal groups; non-obese control (NOC) obese control (OC), non-obese injury (NOH), obese injury (OH), non-obese adipose (NOY), obese adipose (OY), non-obese nerve (NOPS), obese nerve (OPS). At the end of 8 weeks, all experimental animals without control groups were subjected to nerve crush procedure and sciatic nerve or fat stem cell homogenates were injected on the treatment group rats, and then, recovery process has been observed and histopathological, stereological, electrophysiological analyses and bioinformatic evaluation were made on removed sciatic nerves. Stereological results showed that adipose homogenate gave more successful results than peripheral nerve homogenates in the NOY group in comparison to the NOPS group in terms of myelinated axon number. Peripheral nerve homogenate has shown more successful results in the OPS group in comparison to the OY group. The number of unmyelinated axons was increased following treatment with adipose tissue homogenate in NOY and OY groups. In terms of myelin sheath thickness; we detected that treatments by peripheral nerve and especially adipose tissue homogenates lead to increase in the thickness of the axons of the peripheral nerves belong to the control and obese injury groups. All results showed that mesenchymal stem cell treatment by fresh tissue homogenates is successful in peripheral nerve regeneration and fat tissue is a considerable source of the stem cells for clinical applications.