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Öğe Alarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case-control study(Wiley, 2022) Gorkem, Umit; Yildirim, EnginAim There is scant evidence concerning the relationship of alarin concentrations for polycystic ovary syndrome (PCOS) status in the existing literature. Therefore, we aimed to reveal the relationship about predictive value of serum alarin concentrations for PCOS risk in infertile women. Methods This prospective case-control study included a total of 151 infertile women who met eligibility criteria of the study. Infertile women diagnosed with PCOS formed the study group (n = 80). Women with diagnoses of unexplained infertility constituted the control group (n = 71). The biochemical analyses of serum concentrations of lipid profiles, estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Mullerian hormone (AMH) and alarin were performed. Results There were no differences for the study parameters, including age, body mass index, fasting glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total triglyceride, E2, and FSH levels in either group. Serum LH, AMH, alarin concentrations, and antral follicle counts had higher values in the PCOS group compared with the controls. Correlation analysis revealed that serum alarin levels were significantly positively correlated with LH and AMH levels, only in the PCOS group. Multivariate binary logistic regression analysis demonstrated that infertile women with high alarin concentrations were significantly more likely to develop PCOS (OR = 1.77, 95% CI = 0.095-0.332, p < 0.001). Conclusion Higher serum concentrations of alarin and a positive correlation with serum LH levels were found in infertile women with PCOS. This evidence supported that high alarin concentrations might play a role in the development of PCOS.Öğe The circulating alarin level was elevated in infertile women with poor ovarian reserve(Taylor & Francis Ltd, 2021) Yildirim, Engin; Gorkem, UmitObjective We aimed to reveal the association of serum alarin level with POR status of the infertile women in the present study. Methods The eligibility criteria for this prospective cross-sectional study included a total of 92 infertile women attending the Hitit University Hospital, and all participant women were categorized into two main groups of ovarian reserve: (i) Poor ovarian reserve (POR) group (n = 40) based on ESHRE consensus and (ii) Control group (NOR) (n = 52). Results The mean adjusted-ages and BMI values of the NOR and POR groups were statistically comparable (p = .057 and p = .600, respectively). The mean E2, FSH, and LH levels were elevated in the POR group (p < .001, for all). The mean AFC and AMH concentration were significantly reduced in the POR group (p < .001, for both). In addition, there was a significant increase in the serum alarin level in the POR group (p < .001). Pearson's analysis revealed that the mean BMI value of the POR group had a weak and negative correlation (r = 0.318, p = .046). Also, there was no correlation between serum alarin with E2 and FSH levels in both study groups. A weak and positive correlation was found between serum alarin and LH concentration only in the POR group (r = 0.318, p = .045). The mean AMH and AFC values were not significantly correlated with serum alarin levels. Conclusion The circulating alarin level was significantly elevated in infertile women with POR patterns. In addition, the alarin level was significantly correlated with the serum LH concentration in the POR pattern.Öğe Comparative bibliometric analysis of fertility preservation(2019) Yildirim, Engin; Demir, EmreAim: Fertility preservation (FP) has become an important issue for both women and men, due to oncological therapies, gonadotoxic treatments, surgeries, and infertility. The aim of this study is to investigate the publications related to FP, identify the top effective countries and journals, top productive researchers, and trend topics. Material and Methods: The data of this study were obtained using the Thomson Reuters WoS (Thomson Reuters, New York, NY, USA) database, separately for females and males. In the bibliometric analysis, ‘fertility preservation’ was used as a keyword. VOSviewer (Version 1.6.6) was utilized for bibliometric network visualizations. SPSS was used for the statistical analyses (Version 22.0)Results: Analysis results of the keywords used for men indicated 817 publications and for females indicated 2531 publications totally. The United States of America (USA) was the top country for the publications about both genders. The top three research fields for both genders were Obstetrics and Gynecology, Reproductive Biology, and Oncology. The journals that contributed to the literature most were Fertility and Sterility and Human Reproduction respectively in both gender categories. The correlation between the number of total fertility preservation articles and total cancers,Gross Domestic Product-World Bank (GDP-WB), Gross Domestic Product-International Monetary Fund (GDP-IMF), Human Development Index (HDI), and Internet Users (IU) was significant (r=0.482, p=0.017; r=0.609, p0.001; r=0.620, p0.001; r=0.365, p=0.043; r=0.479, p=0.006). Conclusion: It has been determined that researches on the protection of the fertility of cancer patients and infertile patients have increased from past to present. Also, it is observed that the economies of countries have an active role in research productivity.Keywords: Bibliometrics; fertility preservation; female; male.Öğe Copeptin: A potential marker for the prediction of poor ovarian reserve in the infertile women(Galenos Publ House, 2022) Gorkem, Umit; Yildirim, EnginObjective: There is actually no evidence regarding the physiological effects of copeptin in infertile women with different ovarian reserve types. This study aimed to investigate the relationship of serum copeptin level with poor ovarian reserve (POR) and to reveal the predictive value of copeptin for POR development in the infertile women. Materials and Methods: All participant women were classified as the control group (n=77) included the women with diagnosis of unexplained infertility and the POR group (n=61) was composed of the women who met the European Society of Human Reproduction and Embryology consensus on POR [serum anti-Mullerian hormone (AMH) concentrations below 1.1 ng/mL]. The biochemical tests, including estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone, AMH and copeptin were analysed. The analyses of serum copeptin concentrations were measured by the means of competitive enzyme immunoassay. Results: A significant increase in the serum copeptin level existed only in the POR group. There was a significant positive correlation between serum copeptin with E2 and FSH levels in the POR group. Significant negative correlations between copeptin and AMH concentrations (r=-0.310, p=0.015) and between copeptin concentration and antral follicle counts (r=-0.284, p=0.027) were detected only in the POR group. The estimated areas under receiver operating characteristic curves for serum concentration were found to be statistically significant with a cut-off value of 3.52 (95% confidence interval 0.519-0.709), sensitivity 0.90 and specificity 0.72. Conclusion: This study confirmed that there was an elevated serum copeptin concentration in the infertile women with POR and that serum copeptin concentration may have a predictive value for POR diagnosis.Öğe The hazardous impacts of multiple repeated cesarean deliveries on adhesion formation and obstetric outcomes(2020) Kan, Ozgur; Gorkem, Umit; Cakir, Caner; Aykilic, Aysegul; Kocak, Ozgur; Yildirim, EnginAim: The aim of this study was to determine whether the impact of repeat cesarean deliveries (CD) and abdominal adhesions on maternal and fetal complications exists in patients with a history of one previous CD and ones with three or more prior CD.Material and Methods: A total of one hundred-one pregnant women with a history of at least one previous CD were included in this prospective observational study. Participants were divided into two groups, patients with a single CD were added to the control group (n=56) and patients with a history of three or more CD were included in the study group (n=45). Preoperative scar characteristics and hemoglobin levels, intraoperative adhesion severity and grade were evaluated by using Linsky and Nair classifications for adhesion. In addition, duration of surgery, maternal complications and fetal status by using APGAR scoring system was analyzed, respectively.Results: Demographic features were comparable between the groups. The differences among the groups were found to be statistically significant in terms of adhesion intensity and grade (1.13 vs 0.42, p0.01 and 1.80 vs 0.89, p0.01, respectively), hemoglobin change (1.42 vs 0.83 mg/dL, p=0.011) and operation duration (47.60 vs 36.82 min, p0.01). In addition, APGAR scores were significantly lower in the multiple repeat cesarean group (1.min; 8.31 vs 8.64, p=0.02 and 5.min 9.37 vs 9.64, p=0.04, respectively).Conclusion: Multiple repeat CD was associated with poor obstetric outcomes and complications. Careful preoperative evaluation and preparation might be useful in reducing complications, especially in patients with a history of three or more CD.Öğe Hyperthermic Intraperitoneal Chemotherapy: A Holistic Investigation of Global Outputs with Bibliometric Analysis(Zamensalamati Publ Co, 2023) Yildirim, Engin; Yilmaz, ErcanBackground: Hyperthermic intraperitoneal administration of chemotherapy (HIPEC) targets microscopic residues remaining after complete cytoreduction. Objectives: We systematically presented the development process of the HIPEC treatment regimen, the most remarkable publications on this topic, the most productive countries, and the future of treatment in the coming years. Methods: The source of our study was the Web of Science (WoS) database which included the Korean Journal Database, core collection index, Russian Science Citation Index, and Sci ELO citation index. Results: We reached a total of 3,343 publications by analyzing the WoS database using the keyword of Hyperthermic intraperitoneal chemotherapy. When the citations of the documents written about HIPEC were evaluated, we found that the highest citation was made in 2019. Co-citation analysis showed that there were 27,724 authors investigating the issue of HIPEC. The most active university was determined as Wake Forest University, USA. Collaboration and citation collaboration was observed between Wake Forest University, the University of Pittsburgh, and the University of Texas. The intersection point of all researcher countries was the USA. While reviewing the articles on HIPEC, we also identified new trends and topics in this regard. Ovarian cancers, gastric cancers, and colorectal cancers were found to be the types of cancer that had the strongest relationship with HIPEC. Conclusion: HIPEC therapies should be considered an area of research that has been studied, published, and cited by surgeons, oncologists, and pharmacologists interested in the treatment of tumors with peritoneal spread.Öğe An interactive web application for propensity score matching with R shiny; example of thrombophilia(2020) Demir, Emre; Kose, Serdal Kenan; Akmese, Omer Faruk; Yildirim, EnginAim: The aim of this study was to develop a new web-based R Shiny package that calculates propensity score using many algorithms such as logistic regression, machine learning, and performs matching analysis with balance evaluation. In addition, it was aimed to explain the process of matching analysis on a real data set by comparing the number of live births between those with methylenetetrahydrofolate reductase (MTHFR) homozygous mutations and those without mutations in women hospitalized due to abortion in the gynecology and obstetrics clinic.Material and Methods: The web-based application was developed using R shiny. The “matchIt” library was used for matching analysis and PS prediction. The “cobalt” library was used to evaluate balance and generate plots.Results: The abortion variable, which was statistically significantly different in the groups before matching (p=0.010), was similar in the groups after matching (p=0.743). In addition, when the descriptive statistics and p values of the other variables were examined, it was seen that almost full balance was achieved after matching and the confounder variables were similar distributed in groups. After matching analysis, it was determined that the result variable “livebirths” did not show statistically significant difference in the groups (p=0.864).Conclusion: In this study, we developed an interactive web application for matching analysis based on propensity score. It is thought that this application will facilitate the studies of the researchers.Öğe Is there a relationship between serum kisspeptin levels and endometrial polyps in women with premenopausal status(2019) Yildirim, Engin; Derici, Mehmet Kursat; Simsek, Omer Yavuz; Demir, EmreAim: Endometrial polyps are frequently associated with abnormal uterine bleeding. The kispeptin family is one of the peptides that play a role in reproductive functions and whose expression varies in various uterine pathologies. The aim of the study was to determine the relationship between serum Kisspeptin levels and endometrial polyps in women with premenopausal status.Material and Methods: The blood was collected prior to endometrial sampling from women admitted to the hospital due to abnormal uterine bleeding. According to the pathology results, patients were identified as polyp group (n=38) (endometrial polyps) and control group (n=50) (normal endometrial findings). Kisspeptin-54 levels were determined by ELISA method from serum obtained from venous blood. Results: There were no difference was found between the patients’ age, body mass index, gravida, para, abortus and the number of living children were compared (p>0.05). There was no statistically significant difference between the groups in terms of follicle stimulating hormone, luteinizing hormone and thyroid stimulating hormone values (p>0.05). Plasma kisspeptin (1.84±0.93 ng/dL and 1.32±0.47 ng/dL, p= 0.008) and estradiol (90.34±13.02 pg/mL and 81.75±12.36 pg/mL, p=0.002) levels were significantly higher in the polyp group than in the control group. After the Receiver Operating Characteristic (ROC) analysis the area under the curve (AUC) was 1.26 (p= 0.08), (95% CI, 0.550-0.782). The sensitivity value was 0.684 (0.512-0.819), the specificity was 0.620 (0.471-0.750).Conclusion: The serum Kisspeptin-54 and estradiol levels were found higher in patients with endometrial polyps.Keywords: Abnormal uterine bleeding; endometrial polyps; kisspeptin.Öğe The relationship between oxidative stress markers and endometrial hyperplasia: A case-control study(Galenos Yayincilik, 2021) Yildirim, Engin; Turkler, Can; Gorkem, Umit; Simsek, Omer Yavuz; Yilmaz, Ercan; Aladag, HulyaObjective: Endometrial hyperplasia (EH) is considered an endometrial cancer precursor. This study aimed to determine the role of oxidative stress and thiol groups with antioxidant properties in EH pathogenesis. Materials and Methods: In our prospective case-control study, participants were washed with 5 mL of saline before the endometrial biopsy. Endometrial washing fluid was taken into microtubules, and thiol and disulfide levels were analyzed using the Ellman reagent. Results: A total of 108 patients were in the EH group and 84 patients in the control group. The total and native thiol levels were higher values in the control group (p<0.001, for both). Disulfide levels were higher in the EH group (p<0.001). Native/total thiol ratio and disulfide/total thiol ratio were higher in the EH group (p<0.001, for both). The analysis performed in the control group revealed a significant positive correlation between estradiol and disulfide levels (r=0.322, p=0.033). No significant correlation was found between estradiol and disulfide in the EH group. Conclusion: Oxidative stress level was higher in the washing fluids of patients with EH and this stress plays a role in the EH etiology.Öğe Scientometric analysis of genital cosmetic and aesthetic procedures between 1981 and 2019(Elsevier Sci Ltd, 2021) Yildirim, Engin[Abstract Not Available]Öğe Serum orexin-A (OXA) level decreases in polycystic ovarian syndrome(Informa Healthcare, 2013) Yilmaz, Ercan; Celik, Onder; Celik, Nilufer; Simsek, Yavuz; Celik, Ebru; Yildirim, EnginAim: In the current study, we aimed to investigate whether serum orexin-A (OXA) levels are different in polycystic ovary syndrome (PCOS) subjects. Materials and methods: Thirty-six women with PCOS and 40 healthy, age and body mass index-matched controls were included in the prospective cross-sectional study. All subjects underwent venous blood draws during the early follicular phase after overnight fasting. Serum OXA levels were measured with an enzyme immunoassay (EIA). The relationships between the serum OXA levels and the anthropometric and metabolic parameters were also assessed. Results: The serum OXA levels were lower in the women with PCOS compared to the control group. The serum OXA levels were correlated negatively with systolic blood pressure, the Ferriman-Gallway score and LH and free testosterone levels. Conclusion: Our results indicate that serum OXA levels decrease in the serum of women with PCOS.Öğe Thrombosis in pregnancy: Scientometric analysis of thrombotic diseases in pregnancy between 1975-2019(2020) Yildirim, Engin; Kahraman, ErcanAim : Thrombosis and embolism during pregnancy have bad obstetric results, and diagnosis and treatment are difficult. The number of publications published about thrombosis and embolism in pregnancy has been increasing gradually. Our aim is to make a comprehensive bibliometric analysis of the literature on thrombosis and embolism during pregnancy. Method and Methods: In this study, we downloaded the data of the publications from the Web of Science Core Collection. All items indexed in these databases between 1975 and 2019 were included. Documents produced in 2020 are excluded. While searching the database, the words 'pregnancy or pregnant', 'thrombosis or embolism' were used as keywords. Results: We found a total of 6885 documents between 1975-2019. The documents obtained were written in 18 different languages, 90.8% of them were produced in English, followed by German with 3.4% and French with 3.1%. The majority of the documents found were original articles. The USA has made tremendous progress in the study of thrombosis and embolism during pregnancy and is still an effective country. The most prolific writer Khamastra M.A. with 85 articles from England. and the most productive university was Mcmaster University, Canada. Conclusion: The issue of thrombosis and embolism should be considered as a widely published and cited study area in both obstetrics and cardiovascular system practice. Clinicians and researchers will be able to easily identify which articles are strong in cardiovascular system diseases and pregnancy, and in which subjects there are more citations.
