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Öğe Effects of agomelatine on rat liver regeneration following partial hepatectomy(Taylor & Francis Ltd, 2023) Kose, A.; Ozhan, O.; Parlakpinar, H.; Vardi, N.; Yildiz, A.; Turkoz, Y.; Erdemli, Z.Primary or metastatic hepatic malignancies are common. Partial hepatectomy (PH) is the primary treatment for both benign and malignant hepatic neoplasms; it also is used for living donor liver transplantation. The regenerative potential of the liver after PH is 70-80% in humans. We investigated the protective and therapeutic effects of agomelatine (AGM) on rat liver regeneration following PH. We used 32 rats distributed equally into four groups: group 1, sham control; group 2, PH group; group 3, administered 20 mg/kg AGM orally once/day for 7 days following PH; group 4, administered 20 mg/kg AGM orally once/day 3 days before and 7 days following PH for 10 days. Liver samples were analyzed for antioxidants and free radicals. Tissue samples were processed and stained with hematoxylin and eosin to assess histopathological status and stained immunohistochemically for Ki-67. We found that PH reduced antioxidant enzymes and increased tissue reactive oxygen species, whereas AGM treatment had the opposite effect on these parameters. Our biochemical and histopathological findings were consistent. PH caused sinusoid congestion and dilation. Intensity of Ki-67 immunostaining of hepatocytes was increased in group 2, whereas these were reduced in group 4. Intensity of Ki-67 immunostaining of hepatocytes was increased in group 2, whereas it was reduced in the group 4 compared to group 1. We found that AGM was hepatoprotective following PH due to its antioxidant and free radical scavenger properties.Öğe Effects of melatonin on acetylsalicylic acid induced gastroduodenal and jejunal mucosal injury(Taylor & Francis Ltd, 2018) Taslidere, E.; Vardi, N.; Parlakpinar, H.; Yildiz, A.; Taslidere, B.; Karaaslan, M. G.We evaluated the effects of melatonin on acetylsalicylic acid (ASA) induced gastroduodenal and jejunal mucosal injury. We used 40 postpubertal rats divided randomly into five groups of eight animals. The control group consisted of untreated animals. The Mel group was injected intraperitoneally (i.p.) with 5mg/kg melatonin. The ASA group was injected i.p. with 200mg/kg ASA. The ASA + Mel group was injected i.p. with 5mg/kg melatonin 45min after administering 200mg/kg ASA i.p. The Mel + ASA group was injected i.p. with 5mg/kg melatonin 45min before administering 200mg/kg ASA i.p. We found no statistically significant differences in mean histopathological scores in the ASA + Mel group compared to the ASA group. ASA caused shortened villi and loss of the apical villus in the duodenum. The histopathological score was increased and villus height was decreased in the ASA group compared to untreated controls. Treatment with melatonin attenuated the histological damage. In the ASA group, occasional areas showed erosion of villi in the jejunum; however, differences in mean histopathological score in ASA group compared to the other groups were not statistically significant. Malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD) activities were measured in stomach, duodenal and jejunum tissue. We found increased MDA activity in both stomach and duodenal tissues in the ASA group compared to the control group (p<0.05). We found no statistically significant changes in MDA levels in jejunal tissue in the ASA group compared to the control group. We found no change in SOD activity in either stomach or duodenal tissues in the ASA group compared to the control group. We observed decreased SOD activity in jejunal tissue in the ASA group compared to the control group (p<0.05). We detected no change in GSH activity in stomach, duodenal or jejunal tissues in the ASA group compared to the control group. The stomach damage was less in melatonin treated groups, but the lesions were not completely eliminated. The jejunum in the ASA group retained a nearly normal appearance. We found that melatonin exhibited some healing effects on ASA induced duodenal mucosal injury.Öğe Effects of molsidomine on retinal ischemia/reperfusion injury in rabbits(Taylor & Francis Ltd, 2018) Polat, N.; Ozer, M. A.; Parlakpinar, H.; Vardi, N.; Aksungur, Z.; Ozhan, O.; Yildiz, A.We investigated the effect of molsidomine (MOL) on ischemia/reperfusion (I/R) injury. Rabbits were assigned to four groups: group 1, sham; group 2, I/R; group 3, MOL treatment for 4days after I/R; group 4, MOL treatment for 1 day before I/R and 3days after I/R. Retinal I/R was produced by elevating the intraocular pressure to 150mm Hg for 60min. Seven days after I/R, the eyes were enucleated. Retinal changes were examined using histochemistry. The levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) also were measured. We found a significant increase in the thickness of the outer nuclear layer of group 3 compared to the other groups. In groups 3 and 4, caspase-3 stained cells in the ganglion cell layer were decreased compared to group 2. We found a significant increase in caspase-3 stained cells in the inner nuclear layer (INL) of group 2 compared to the other groups. We found a significant increase in caspase-3 stained cells in group 3 compared to group 4 in the INL. The MDA level in group 2 was significantly higher than group 1 and MOL significantly decreased MDA levels in groups 3 and 4. We found that MOL protected the retina from I/R injury by enhancing antioxidative effects and inhibiting apoptosis of retinal cells.Öğe Effects of various conditions related to circadian rhythm disturbances on plasma and erythrocyte lipids: a peroxisomal perspective(Wiley, 2021) Otlu, H. G.; Ugur, Y.; Yildiz, A.; Erdogan, S.; Yologlu, S.; Vardi, N.; Guldur, T.[Abstract Not Available]Öğe EFFECTS OF WHOLE BODY VIBRATION EXERCISE ON MUSCLE STRENGTH AND REFLEX MYOELECTRICAL ACTIVITY: BONE MYOREGULATION REFLEX AS A POTENTIAL NEUROMUSCULAR MECHANISM(Springer London Ltd, 2012) Cidem, M.; Karacan, I.; Diracoglu, D.; Yildiz, A.; Kucuk, S. H.; Uludag, M.; Karakoc, Y.[Abstract Not Available]Öğe EVALUATION OF POTENTIAL EFFECTS OF DIMETHYLSULFOXIDE (DMSO) AS A CRYOPROTECTANT DURING THAWING PERIOD(Amer Soc Cell Biology, 2015) Guner, D. C.; Sirolu, C.; Yildiz, A.; Gul, C. C.; Isan, H.; Aktas, R. G.[Abstract Not Available]Öğe INVESTIGATING EFFECTS OF GRAPE SEED EXTRACT ON NEUROPATHIC PAIN IN THE STREPTOZOTOCIN-INDUCED DIABETIC MICE(Dnipropetrovsk State Medical Acad, 2019) Yurt, A.; Koksal, B.; Gurbuz, P.; Yildiz, A.; Vardi, N.; Alcin, E.Diabetes mellitus is a complicated and serious health problem involving peripheral neuropathy. This situation causes to loss of senses, tingle and pain. Diabetic peripheral neuropathy (DPN) affects 236 million people around the World. Hence there is a need to investigate alternative ways of cure focusing on DPN. Flavonoids have potential on pain due to their permeability characteristic in the capillary microcirculation system and in lowering blood pressure. Flavonoids are common in grape seed. The main flavonoids of grape seed involve proanthocyanidins which might be an effective agent in cure of pain in DPN. The purpose of this study is to investigate effects of grape seed extract on neuropathic pain in the Streptozotocin-induced diabetic mice. In the study, 50 eight-week old BALB-C strain mice in five different groups (Control, Diabetic Control, Control+25 mg/kg, Diabetes+25 mg/kg and Diabetes+50 mg/kg) were used. To induce diabetes in thirty of these animals, single dose Streptozotocin (180 mg/kg) was administered intraperitoneally. After diabetes was observed, grape seed extract (25 mg/kg and 50 mg/kg body weight) was administered by oral gavage in three groups (Control+25 mg/kg, Diabetes+25 mg/kg and Diabetes+50 mg/kg) during six weeks. At the end of the second and sixth weeks, pain threshold measurements in hot plate test were performed in line with a predetermined thermal pain model. Also the tissues of the sciatic nerve and abdominal aorta from the animals were histologically investigated. As a result hot plate measurements, pain threshold values of the animals in Diabetes+50mg/kg group significantly differed from the measurements of the animals in control group in the first measurements and from the animals in Diabetes+25 mg/kg group in the second measurements (p<0.05). However pain threshold values of the animals in Diabetes+25 mg/kg group differed significantly from the values of the animals in control+25 mg/kg group and control group. It means pain threshold values of the animals in Diabetes+50 mg/kg and Diabetes+25 mg/kg groups were significantly lower than the values of the animals in the other groups. The results of histological investigations showed that degenerations of myelin sheet and axons in diabetic control group were decreased significantly in Diabetes+50 mg/kg and Diabetes+25 mg/kg groups. Moreover degenerations of aorta tissues of animals in diabetic group were not seen in the animals of Diabetes+50 mg/kg except for tunica adventitia inflammation. It can be said that grape seed extract decreased threshold of neuropathic pain in the Streptozotocin-induced diabetic mice and prevented degenerations of myelin sheet and axons, and aorta tissues.Öğe ON A CLASS OF GENERALIZED SASAKIAN-SPACE-FORMS(Comenius Univ, Sch Medicine, 2018) Majhi, P.; De, U. C.; Yildiz, A.The object of the present paper is to study quasi-conformally flat generalized Sasakian-space-forms. Also we study quasi-conformally semisymmetric generalized Sasakian-space-forms. As a consequence of the results, we obtain some important corollaries.Öğe The protective effect of melatonin in lungs of newborn rats exposed to maternal nicotine(Taylor & Francis Ltd, 2018) Yildiz, A.; Vardi, N.; Karaaslan, M. G.; Ates, B.; Taslidere, E.; Esrefoglu, M.We investigated possible healing effects of melatonin (MEL) on biochemical and histological changes in the lungs of rat offspring caused by exposure to nicotine (NT) in utero. Pregnant rats were divided randomly into five groups. The SP group was treated with physiological saline. The EA group was treated with ethyl alcohol. The MEL group was treated with MEL. The NT group was treated with NT. The NT + MEL group was treated with NT and MEL. At the end of the study, the biochemistry and histopathology of lung tissue of the offspring were examined. Reduced alveolar development and increased numbers of alveolar macrophages and mast cells were observed in the NT group compared to the SP, EA and MEL groups. We also found increased malondialdehyde (MDA) levels and decreased total glutathione (GSH) levels in the NT group. Application of MEL ameliorated the histological and biochemical damage caused by NT. The number of alveoli was greater in the NT + MEL group than in the NT group. Also, the increased numbers of alveolar macrophages and mast cells resulting from exposure to NT were decreased following MEL treatment. We found that MEL caused a significant decrease in the level of MDA. Maternal exposure to NT caused significant structural and biochemical changes in the lungs of the offspring and administration of MEL ameliorated the changes.Öğe Protective effect of short-term thymoquinone administration on the central nervous system in cisplatin-induced neurotoxicity(Verduci Publisher, 2022) Durak, M. A.; Ozhan, O.; Yildiz, A.; Durhan, M.; Vardi, N.; Cigremis, Y.; Parlakpinar, H.OBJECTIVE: This study was performed to investigate the potential benefi- cial effects of thymoquinone (TQ) on brain tis-sue based on biochemical and histopathologi-cal analyses in cisplatin (CIS) treated rats with central nervous system (CNS) neurotoxicity. MATERIALS AND METHODS: The rats were randomly divided into 4 groups with 8 rats in each group (n:8). Group 1: (Control), saline was administered for 3 days at a volume of 0.5 ml per day intraperitoneal (i.p.). Group 2: (CIS Group), one dose of CIS was administered (7 mg/kg i.p.). Group 3: (TQ Group), TQ was giv-en at a dose of 5 mg/kg per day for 3 days (i.p.). Group 4: (CIS+TQ Group), one dose of 7 mg/ kg was initiated half an hour before adminis-tration of CIS and one dose of 5 mg/kg per day was administered TQ i.p. for 3 days. RESULTS: Malondialdehyde levels were found to be statistically significantly higher in the CIS group compared to the control group. Degenerative changes observed in the CIS+TQ group were found to be milder than in the CIS group. In the CIS+TQ group, a statistically sig-nificant decrease in the severity of caspase-3 immunoreactivity was found when compared to the CIS group. It was found that the sever-ity of neurofilament immunoreactivity moni- tored in neuronal extensions was similar in all groups. In the CIS+TQ group, the severity of tau protein's immunoreactivity was similar to that of the CIS-group.CONCLUSIONS: According to the results obtained in our study, beneficial effects were obtained in reducing neurotoxicity with short-term TQ application in rats treated with CIS treatment.
