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Öğe Activation of the Mas receptors by AVE0991 and MrgD receptor using alamandine to limit the deleterious effects of Ang II-induced hypertension(Wiley, 2023) Tanriverdi, Lokman Hekim; Ozhan, Onural; Ulu, Ahmet; Yildiz, Azibe; Ates, Burhan; Vardi, Nigar; Acet, Haci AhmetThe MrgD receptor agonist, alamandine (ALA) and Mas receptor agonist, AVE0991 have recently been identified as protective components of the renin-angiotensin system. We evaluated the effects of ALA and AVE0991 on cardiovascular function and remodeling in angiotensin (Ang) II-induced hypertension in rats. Sprague Dawley rats were subject to 4-week subcutaneous infusions of Ang II (80 ng/kg/min) or saline after which they were treated with ALA (50 mu g/kg), AVE0991 (576 mu g/kg), or ALA+AVE0991 during the last 2 weeks. Systolic blood pressure (SBP) and heart rate (HR) values were recorded with tail-cuff plethysmography at 1, 15, and 29 days post-treatment. After euthanization, the heart and thoracic aorta were removed for further analysis and vascular responses. SBP significantly increased in the Ang II group when compared to the control group. Furthermore, Ang II also caused an increase in cardiac and aortic cyclophilin-A (CYP-A), monocyte chemoattractant protein-1 (MCP-1), and cardiomyocyte degeneration but produced a decrease in vascular relaxation. HR, matrix metalloproteinase-2 and -9, NADPH oxidase-4, and lysyl oxidase levels were comparable among groups. ALA, AVE0991, and the drug combination produced antihypertensive effects and alleviated vascular responses. The inflammatory and oxidative stress related to cardiac MCP-1 and CYP-A levels decreased in the Ang II+ALA+AVE0991 group. Vascular but not cardiac angiotensin-converting enzyme-2 levels decreased with Ang II administration but were similar to the Ang II+ALA+AVE0991 group. Our experimental data showed the combination of ALA and AVE0991 was found beneficial in Ang II-induced hypertension in rats by reducing SBP, oxidative stress, inflammation, and improving vascular responses.Öğe Alamandin and especially melatonin attenuate pulmonary arterial hypertension induced by monocrotalin(Wiley, 2024) Ayik, Seyhan; Gunata, Mehmet; Ozhan, Onural; Yildiz, Azibe; Vardi, Nigar; Sonmez, Emre; Ermis, NecipBackgroundDespite the available treatments, pulmonary arterial hypertension (PAH) prognosis is poor.ObjectivesWe aimed to investigate the effects of the alamandine (ALA), melatonin (MEL), and ALA + MEL in PAH.MethodsThe rats were randomly divided into Control (n = 10), monocrotaline (MCT) (n = 12), ALA (n = 12), MEL (n = 12), and ALA + MEL (n = 12) groups. PAH was induced by MCT. The ALA, MEL, and ALA + MEL groups received 50 mu g/kg/day ALA, 10 mg/kg/day MEL, and ALA + MEL, respectively, for 35 days. Echocardiographic and hemodynamic measurements and tissue analyses (morphometric, histopathological, ELISA, and western blot) were performed.ResultsMonotherapies, especially MEL, reduced the right ventricular (RV) systolic pressure. Only MEL increased the pulmonary artery acceleration time. MCT increased the RV/left ventricle (LV) + interventricular septum (IVS) ratio. While ALA and ALA + MEL slightly decreased the RV/(LV + IVS), MEL significantly restored it. MCT increased the tunica intima-media (TIM) thickness, PCNA and alpha-SMA of pulmonary arterioles, histopathological score (HS) (inflammatory infiltration etc.) of the lung, and RV. All treatments reduced the TIM thickness (especially MEL), PCNA, and alpha-SMA. All treatments significantly decreased the HS of the lung; however, MEL and ALA + MEL produced greater benefits. All treatments attenuated the HS of RV. MCT caused a significant increase in lung lysyl oxidase (LOX) activity. All treatments restored the LOX; however, MEL and ALA + MEL provided greater improvement. While lung Nrf-2 was increased in MCT-treated rats, MEL reduced it.ConclusionALA, MEL, and ALA + MEL attenuate PAH and protect RV via antiproliferative, anti-remodeling, antihypertrophic, anti-inflammatory, and free radical scavenging (only MEL) capabilities. Overall, MEL produced the best outcomes.Öğe Alamandine: Protective Effects Against Renal Ischemia-Reperfusion Injury-Induced Renal and Liver Damage in Diabetic Rats(Wiley, 2025) Cengiz, Ayse Nuransoy; Ozhan, Onural; Tanriverdi, Lokman Hekim; Dogru, Feyzi; Yildiz, Azibe; Polat, Alaadin; Vardi, NigarAlamandine (ALA) is a heptapeptide discovered in 2013 within the renin-angiotensin system (RAS). Given the high prevalence of diabetes mellitus (DM) in society and its comorbidities, especially renal failure, which significantly impairs the quality of life, this study aimed to investigate the protective effects of ALA against renal ischemia-reperfusion (I/R) injury in diabetic rats. Our aim was to develop preventive therapies for DM and diabetic renal failure. Forty-eight 3-month-old male Sprague-Dawley rats were induced by administering a single intraperitoneal dose of 50 mg/kg of streptozotocin (STZ). Rats were divided into four groups. Right nephrectomy was performed through dorsolateral incisions in all rats, followed by occlusion of the left renal vessels for 1 h to induce ischemia. Reperfusion of the left kidney was initiated by removing the clamp and allowing 24 h of reperfusion. Histopathological examination of the kidney tissues revealed necrotic changes and tubular dilatation in the I/R group, which were significantly reduced in the ALA + I/R group. Immunohistochemical analysis showed increased immunoreactivity for interleukin-6 (IL-6) and caspase-3 in the I/R group, whereas the ALA + I/R group demonstrated significantly lower immunoreactivity for these markers. Liver histology showed irregular hepatocyte cords and sinusoidal dilatation in the I/R group, whereas the ALA + I/R group exhibited a preserved classical lobular structure with reduced histopathological changes. Blood parameters, serum biochemistry, and tissue findings were also analyzed. Our study demonstrated the protective effects of ALA on renal and liver tissues against damage induced by renal I/R injury in a diabetic background. Moreover, ALA exhibited protective effects against liver damage resulting from renal I/R injury.Öğe Ameliorative effects of aminoguanidine on rat aorta in Streptozotocin-induced diabetes and evaluation of ?-SMA expression(Turkish Soc Cardiology, 2014) Elbe, Hulya; Vardi, Nigar; Orman, Dogan; Taslidere, Elif; Yildiz, AzibeObjective: Diabetes mellitus is one of the chronic metabolic diseases which is characterized by microvascular and macrovascular complications. This study was designed to investigate the improving the effects of amnioguanidine on aortic damage in a streptozotocin (STZ) induced diabetic rat model. Methods: Thirty-two male Sprague-Dawley rats divided into four groups as follows: Control, Aminoguanidine, Diabetes, and Diabetes+Aminoguanidine. Experimental diabetes was induced by single dose STZ (45 mg/kg) intraperitoneally. After administration of STZ, the DM+AMG group began to receive AMG (1 g/L) was prepared by dissolving in tap water during 10 weeks. At the end of the study, blood glucose levels were determined and rats were sacrified by ketamine anesthesia. Following routine tissue process, aortas were embedded in paraffin. Histochemical (H-E and Orcein) and immunohistochemical alpha-smooth muscle actin (alpha-SMA) stains were applied and the sections examined by light microscope. Statistical analysis was carried out using the SPSS 13.0 statistical program. Results: The rats in diabetes group had significantly higher blood glucose levels than the rats of control. The main histological alterations were detected in tunica media such as extensive thickening (414.32 +/- 9.62 mu m), irregular of elastic fibers and intensive alpha-SMA staining in diabetic rats. The thickness of tunica media was statistically increased in DM group, when compared with the control group (p<0.001). On the other hand, AMG prevented disorganization of elastic fibers and overexpression of alpha-SMA. The mean thickness of tunica media was decreased significantly in DM+AMG (319.16 +/- 6.53 mu m) compared with the DM group (p<0.001). Conclusion: Our results demonstrate that AMG treatment may protect the impairment of aort structure at histological level.Öğe Angiotensin II type 2 receptor agonist treatment of doxorubicin induced heart failure(Taylor & Francis Ltd, 2023) Ermis, Necip; Ulutas, Zeynep; Ozhan, Onural; Yildiz, Azibe; Vardi, Nigar; Colak, Cemil; Parlakpinar, HakanDoxorubicin (DOX) is an anthracycline derivative used for treatment of malignancies; however, its clinical use is limited by its cardiotoxicity. We investigated the effects of angiotensin II type 2 receptor agonist compound 21 (C21) on DOX induced heart failure in rat heart. We compared C21 with losartan (LOS), an AT 1 receptor antagonist used for treating heart failure. We allocated 40 rats into five groups of eight: saline treated control group, DOX group administered a single 20 mg/kg dose of DOX, DOX + C21 group administered 0.3 mg/kg C21 for 21 days following the 20 mg/kg dose of DOX, DOX + losartan (LOS) group administered a 21 day regimen of 20 mg/kg LOS following the single dose of DOX, and a DOX + LOS + C21 group administered 0.3 mg/kg C21 and 20 mg/kg LOS for 21 days following the single dose of DOX. We assessed histopathology and conducted echocardiograpic and hemodynamic measurements. Left ventricular ejection fraction (EF) was reduced only in the DOX treated group. C21, LOS and C21 + LOS therapy prevented decreased EF due to DOX. Less histopathology was observed in the DOX + LOS + C21 group than for the other treatment groups. Application of C21 decreased DOX induced cardiac injury similar to LOS. Combined use of C21 and LOS was most beneficial for DOX induced heart failure.Öğe Asprosin protects against ischemia/reperfusion-induced kidney injury in mice(Springer, 2025) Keskin, Tuba; Korkmaz, Engin; Yildiz, Azibe; Tekin, Cigdem; Beytur, Ali; Tekin, SuatIschemia-reperfusion (IR)-induced acute kidney injury (AKI) is a complex pathophysiological process involving inflammation, oxidative stress, and apoptosis. Asprosin (ASP), a fasting-induced glucogenic hormone, has been shown to influence oxidative and apoptotic pathways in various tissues. This study investigated the potential renoprotective effects of ASP in a murine model of IR-induced AKI. Thirty-two male Balb/c mice were randomly assigned to four groups (n = 8): Control, IR, ASP1 (1 mu g/kg ASP), and ASP10 (10 mu g/kg ASP). While the control group received no treatment. Vehicle and ASP (1 or 10 mu g/kg) were administered intravenously five minutes before ischemia to the IR and ASP-treated groups, respectively. Renal ischemia was induced for 22 min, followed by a 24-h reperfusion period. Renal function markers, inflammatory cytokines, oxidative stress parameters, and caspase-3 expression were evaluated. Histopathological alterations were assessed using hematoxylin-eosin staining. IR significantly increased BUN, creatinine, IL-1 beta, TNF-alpha, MDA levels, and caspase-3 expression, while reducing antioxidant enzymes (SOD, CAT). ASP pretreatment effectively reversed these changes (p < 0.05), as reflected by improved renal function, reduced inflammation and oxidative stress, and decreased apoptotic activity. These functional and molecular improvements were also supported by histological evidence showing reduced kidney damage following ASP treatment. Collectively, the findings suggest that ASP protects against IR-induced AKI by alleviating inflammation, oxidative stress, and apoptosis.Öğe Asprosin Takes a Protective Role in Mice Established Experimental Acute Kidney(Wiley, 2023) Korkmaz, Engin; Keskin, Tuba; Yildiz, Azibe; Tekin, Cigdem; Tekin, Suat; Beytur, Ali[Abstract Not Available]Öğe Cardiovascular impact of consumption of sulfured-dried Malatya apricots (Prunus armeniaca L.) at varying SO2 levels: A comprehensive assessment in a rat model(Pergamon-Elsevier Science Ltd, 2025) Ayik, Seyhan; Yildiz, Azibe; Ozhan, Onural; Karaca, Yucel; Taslidere, Elif; Ermis, Necip; Vardi, NigarApricots known as sulfured-dried are those dried under the sun with sulfur dioxide (SO2), which extends their shelf life. Although sun-dried apricots are renowned for their cardiovascular benefits, the cardiovascular effects of sulfured-dried apricots (SDAs) remain poorly understood. To address this knowledge gap, we designed the present study to investigate the cardiovascular effects of consuming SDAs at varying SO2 levels in a rat model. The rats were randomly assigned to 6 groups. The Control group received standard rat chow, while the other 5 groups were fed a diet containing 10 % SDAs with differing SO2 concentrations (1500 ppm, 2000 ppm, 2500 ppm, 3000 ppm, and 3500 ppm) for 24 weeks. After echocardiography and hemodynamic assessment, cardiac histopathology and serum biochemistry were evaluated. Our findings indicate that an SDA diet containing 3500 ppm SO2 leads to myocardial damage and subsequent cardiac dysfunction, likely through TNF-alpha-mediated inflammation and apoptosis. In contrast, diets containing SDAs with SO2 levels between 1500 and 2500 ppm appeared to pose minimal cardiovascular risk. Because in these groups, there was no evidence of myocardial damage, cardiac inflammation, apoptotic cell death, or cellular stress in the cardiac myocytes. Also, these groups showed normal cardiac function in echocardiographic assessments. These results suggest that consuming SDAs with SO2 concentrations up to 2500 ppm SO2 may be safe for cardiovascular health.Öğe Comparison of cilomilast, tadalafil, and both drug combinations in the treatment of monocrotaline-induced pulmonary arterial hypertension in rats(Bmc, 2025) Ermis, Necip; Ozhan, Onural; Yildiz, Azibe; Ulutas, Zeynep; Parlakpinar, Hakan; Ulu, Ahmet; Ates, BurhanBackground Pulmonary arterial hypertension (PAH) is a progressive disease characterized by endothelial dysfunction and inflammation. This study aimed to evaluate the effects of cilomilast (CIL), a phosphodiesterase-4 inhibitor, and tadalafil (TAD), a phosphodiesterase-5 inhibitor, on PAH induced by monocrotaline (MCT) in rats. Methods Forty Wistar albino rats were divided into five groups: control, MCT, MCT + CIL, MCT + TAD, and MCT + CIL + TAD. PAH was induced via MCT, and treatments were administered orally from days 21 to 35. Hemodynamic parameters, right ventricular pressure (RVP), echocardiographic findings, and histopathological lung and heart tissue changes were assessed. Nitric oxide (NO) levels in lung tissue were also measured. Results Tissue NO levels were significantly greater in the MCT + CIL + TAD group than in the MCT group (p = 0.01). The RVP was lower in the MCT + TAD and MCT + CIL + TAD groups than in the MCT group (p < 0.05) but not in the MCT + CIL group. Histopathologically, lung perivascular infiltration and pulmonary artery wall thickness were significantly reduced in the MCT + CIL + TAD group, indicating an anti-inflammatory effect. However, CIL alone did not significantly impact pulmonary artery thickening or RVP. Conclusion CIL alone had no significant effect on PAH progression, but its combination with TAD improved inflammation scores and NO levels. These findings suggest that targeting inflammation alongside vasodilation may offer therapeutic benefits in PAH. Further studies with different doses and PAH models are recommended.Öğe Does apocynin increase liver regeneration in the partial hepatectomy model?(Tubitak Scientific & Technological Research Council Turkey, 2023) Bilgic, Yilmaz; Kanat, Burhan Hakan; Ozhan, Onural; Yildiz, Azibe; Aksungur, Zeynep; Erdemli, Mehmet Erman; Vardi, NigarBackground/aim: Hepayocyte loss may develop secondary to liver surgery and at this point liver regeneration plays a significant act in terms of liver reserve. The purpose of this research was to investigate the efficacy of apocynin on liver regeneration and preservation after partial hepatectomy in rats.Materials and methods: A total of 32 rats, have been divided into 4 groups (n: 8) for hepatectomy model. Inflammatory and antiinflammatory parameters were measured from blood and liver tissue samples. In addition, the effects of apocynin were examined immunohistochemically and histopathologically from liver tissue. Results: In liver tissue samples, a significant difference has been found in glutathione peroxidase, total nitrite, catalase, oxidative stress index, total antioxidant and total oxidant status between sham and hepatectomy groups. A significant difference has been achieved between hepatectomy and posthepatectomy-Apocynin in terms of glutathione peroxidase and oxidative stress index. Total antioxidant status, oxidative stress index, and total oxidant status were significantly different only between the sham and the hepatectomy groups. Statistical differences were found between sham and hepatectomy groups and between hepatectomy and pre+post-hepatectomy-Apocynin groups in terms of serum glutathione, malondialdehyde, total nitrite, and L-Arginine. There were significant differences between the sham and hepatectomy groups, between hepatectomy and posthepatectomy-apocynin groups, between posthepatctomy-apocynin and pre+posthepatectomy-apocynin groups in terms of sinusoidal dilatation, intracytoplasmic vacuolization and glycogen loss (p < 0.001), in all histopathologic parameters except sinusoidal dilatation (p < 0.05). However, significant Ki-67 increases have been elaborated in hepatectomy, posthepatectomy-apocynin, and pre+posthepatectomy-apocynin groups compared to sham group (p < 0.001), in pre+posthepatectomy apocynin group compared to hepatectomy and posthepatectomy-apocynin groups (p < 0.001). Conclusion: Histopathology, immunohistochemistry, and biochemistry results of this study revealed that apocynin has a protective effect on enhancing liver regeneration in partial hepatectomy cases in rats.Öğe Does Maternal Viral Infection At A Critical Window Of Fetal Hypthalamic Nuclei Development Program Puberty And Gonadal Development In Male Rat Offsprings?(Wiley-Blackwell, 2015) Cakan, Pinar; Yildiz, Sedat; Ozgocer, Tuba; Yildiz, Azibe; Vardi, Nigar[Abstract Not Available]Öğe Dose-related effects of dexmedetomidine on wound healing: evaluating fibroblast activation, collagen synthesis, and prolidase activity(Springer London Ltd, 2025) Karaaslan, Erol; Ozkan, Ahmet Selim; Uremis, Nuray; Turkoz, Yusuf; Yildiz, Azibe; Guldogan, Emek; Vardi, NigarBackgroundDexmedetomidine (Dex) is known for extending the time of action and enhancing the analgesic efficacy of local anesthetics. However, its effects on surgical wound healing have not been comprehensively investigated.AimThis study aims to thoroughly examine the effects of subcutaneously administered Dex on wound healing in rats.Methods32 rats in total were randomly distributed into four groups: Control, 3 ml Saline (Group I), 5 mu g/kg Dex (Group II), 30 mu g/kg Dex (Group III), and 60 mu g/kg Dex (Group IV). After the procedure, samples were collected from the surgical wound site on the 7th day. Several wound-healing-related parameters were measured, including arginase, collagen type I, hydroxyproline, Xaa-Pro dipeptidase/prolidase, transforming growth factor-beta (TGF-beta 1), and basic fibroblast growth factor (bFGF). Additionally, the immunoreactivity of proliferating cell nuclear antigen (PCNA) and vascular endothelial growth factor (VEGF) proteins was assessed to evaluate connective tissue cell proliferation and blood vessel development in the dermis.ResultsHydroxyproline (ng/ml) levels were significantly higher in Groups II, III, and IV compared to Group I. Statistically significant differences were also observed between the groups for Arginase (ng/ml), Collagen Type I (ng/ml), TGF-beta 1 (ng/L), and bFGF (ng/L) values. PCNA immunoreactivity was significantly higher in the 30 mu g/kg group than in other groups. VEGF immunoreactivity was significantly higher in the 5 mu g/kg group.ConclusionThe subcutaneous administration of Dex did not negatively impact wound healing in rats. Histological and biochemical findings showed that doses of 5 and 30 mu g/kg promoted the fastest wound closure and supported homogeneous tissue formation. These results suggest that dexmedetomidine has therapeutic potential in wound healing.Öğe Effect of caffeic acid phenethyl ester in doxorubicin induced descending aorta damage(Natl Inst Science Communication-Niscair, 2024) Disli, Olcay Murat; Erdil, Nevzat; Akca, Baris; Ozhan, Onural; Durhan, Merve; Yildiz, Azibe; Cigremis, YilmazDoxorubicin (DOX), a chemotherapeutic agent used in cancer treatment, can cause cardiotoxicity as an adverse effect. In this study, potential protective effect of Caffeic acid phenethyl ester (CAPE), a well-known antioxidant agent, was investigated in doxorubicin induced aortic damage model. Total of 28 adult Wistar albino rats were equally divided into four groups as: Control, DOX, CAPE+DOX, CAPE. Accordingly, 10 mu mol/kg CAPE for 10 days and/or 10 mg/kg doxorubicin for 3 days was given intraperitoneally. Control group received saline and ethanol as the vehicles of doxorubicin and CAPE, respectively. GSH, MDA, CuZn-SOD and CAT levels in descending aorta were investigated as the oxidative stress markers and histopathological changes were evaluated. GSH level was significantly higher in CAPE group as compared to the other groups (P <0.05) while there were no significant differences in MDA, CuZn-SOD and CAT levels among the groups (P>0.05). In microscopic view, tunica media of aorta was significantly thinner in DOX group as compared to CAPE group. Tunica media thickness significantly increased in CAPE+DOX group as compared to DOX group. CAPE treatment ameliorates the histopathological changes that are characterized by the reduced wall thickness induced by doxorubicin. However, CAPE treatment did not seem to effect biochemical parameters that are indicative of oxidative stress. The results indicated that CAPE can be protective against doxorubicin induced aortic vessel damage.Öğe The Effect of Ceftriaxone on Testicular Connexin 43 Expression.(Sage Publications Inc, 2016) Sahin, Levent; Sahin, Hilal; Vardi, Nigar; Karahan, Feride; Yildiz, Azibe; Taslidere, Elif; Gul, Semir[Abstract Not Available]Öğe The Effect of Curcumin on Brain TRPM2 Channel Gene mRNA Expression Level in Experimental Alzheimer's Rat Model Induced by Application of Intracerebroventricular Streptozotocin(Karger, 2018) Durhan, Merve; Tunc, Selahattin; Tekin, Suat; Kaya, Gul Busra; Yildiz, Azibe; Cigremis, Yilmaz[Abstract Not Available]Öğe The Effect of Exenatide Treatment on Myocardial Alterations in a Rat Polycystic Ovary Syndrome Model(Wiley-Blackwell, 2016) Kirimhan, Burcu; Vardi, Nigar; Yildiz, Azibe; Yildiz, Sedat; Alcin, Ergul[Abstract Not Available]Öğe Effects of antiepileptic drugs on ovaries of female Wistar rats(Taylor & Francis Ltd, 2022) Osmanlioglu, Seyma; Yildiz, Azibe; Vardi, Nigar; Karaaslan, Merve; Ozhan, Onural; Parlakpinar, HakanValproate (VPA) induced changes in ovarian morphology are observed in humans with epilepsy and in non-epileptic animals. The effects of lamotrigine (LTG) on female reproduction is not well known. We investigated whether LTG might be a safer drug for use with patients of reproductive age. Forty Wistar albino female rats were divided into five groups. The control group was injected with saline-vehicle solution. The low dose (LD)-VPA group was injected with 100 mg/kg VPA. The high dose (HD)-VPA group was injected with 500 mg/kg VPA. The LD-LTG group was injected with 10 mg/kg LTG. The HD-LTG group was injected with 50 mg/kg LTG. We evaluated histological and biochemical changes in the ovaries. The number of atretic and cystic follicles was increased in the HD-VPA and HD-LTG groups compared to the control group. A significant increase in malondialdehyde level was found in the VPA groups compared to the control and LTG groups. No significant differences in total glutathione levels or superoxide dismutase activity were found among study groups. Catalase activity was significantly higher in HD-VPA and HD-LTG groups compared to the control, LD-VPA and LD-LTG groups. Prevalence and intensity of caspase-3 immunoreactivity in the luteal cells were significantly greater in the HD-LTG group compared to the control group. VPA administration caused polycystic ovarian syndrome-like changes in the ovary. We found that LD-LTG, which reflects the dose for humans, might be a safer option for use during the reproductive age.Öğe Effects of apocynin on sciatic nerve injury in rabbits(Taylor & Francis Ltd, 2023) Durak, Mehmet Akif; Ozhan, Onural; Tetik, Bora; Yildiz, Azibe; Aksungur, Zeynep; Vardi, Nigar; Turkoz, YusufWe investigated the effects of apocynin (APO) on experimental sciatic nerve compression injury in rabbits. We used 21 male rabbits divided randomly into three groups of seven. The control group was subjected to sciatic nerve compression with no further intervention. The APO treated group was subjected to compression injury and 20 mg/kg APO was administered daily for 21 days by intraperitoneal injection beginning the day after the injury. The sham group was treated with APO without injury. The control group exhibited shrinkage of axons, disruption of myelin sheaths and loss of nerve fibers. The damage for the control group was significantly greater than for the sham group. The severity of histopathology was decreased in the APO treated group compared to the control group, as was the oxidative stress index. Our findings suggest that APO treatment may contribute to healing of sciatic nerve damage.Öğe Effects of CAPE on biochemical, histopathological and cardiac parameters in doxorubicin induced cardiotoxicity(Kare Publ, 2025) Disli, Olcay Murat; Akca, Baris; Erdil, Nevzat; Ozhan, Onural; Durhan, Merve; Yildiz, Azibe; Ulutas, ZeynepOBJECTIVE: In this study, the protective effect of Caffeic acid phenethyl ester (CAPE) against doxorubicin (DOX)-induced cardiotoxicity was investigated by evaluating oxidative stress parameters, ECG changes, matrix metalloproteinase 2 (MMP-2) gene expression, troponin I level and histopathology in Wistar Albino rats. METHODS: Forty rats were divided into 4 groups (n=10) including control (saline (vehicle for DOX) and 2.5% ethanol (vehicle for caffeic acid phenethyl ester), CAPE only (10 mu mol/kg bw), DOX only (10 mg/kg bw) and CAPE+DOX groups. Molecular, biochemical and histopathological analyses were performed on blood and heart tissues. RESULTS: No alterations were observed in oxidative stress parameters and MMP-2 gene expression of DOX and CAPE+DOX groups compared to control. Troponin I levels were higher in DOX and CAPE+DOX groups than in the control. Variable ECG changes were observed in the experimental groups such as increased systolic blood pressure, decreased QRS and QT interval in DOX group compared to the control without any ameliorative effect of CAPE. The presence of dense degenerative cardiomyocytes in the myocardium of the DOX group was noted. DOX caused damage to cardiomyocytes. It was observed that CAPE showed a significant decrease in histopathological changes and histopathological scoring in the CAPE+DOX group compared to DOX group. CONCLUSION: CAPE treatment ameliorated histopathological changes induced by DOX while other parameters including oxidative stress, MMP-2 gene expression, Troponin I and ECG studied in our study were not altered remarkably.Öğe Effects of Grape Seed Extract on Diabetic Neuropathy in Mice(Wiley-Blackwell, 2015) Yurt, Aysegul; Koksal, Burcu; Gurbuz, Perihan; Yildiz, Azibe; Vardi, Nigar; Alcin, Ergul[Abstract Not Available]
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