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    The effect of functional remission and cognitive insight on criminal behavior in patients with schizophrenia
    (W B Saunders Co-Elsevier Inc, 2023) Polat, Hatice; Ugur, Kerim; Aslanoglu, Eren; Yildiz, Sevler; Yagin, Fatma Hilal
    Objective: This study was planned to determine the relationship of functional remission with a criminal history and determine its effect on criminal behavior in patients with schizophrenia.Methods: This cross-sectional study was conducted with 132 patients with schizophrenia (66 with and 66 without a criminal history). Data were collected between November 2020 and April 2021 using a personal information form, the Functional Remission of General Schizophrenia (FROGS), the Taylor Crime Violence Rating Scale, the Beck Cognitive Insight Scale, and the Positive and Negative Syndrome Scale (PANSS) was used to collect data.Results: In terms of all scale variables, there were significant differences between the groups with and without a criminal history (p < 0.05). These differences were mostly clearly observed in the FROGS-social functionality (effect size: 16.79), PANSS-positive (effect size: 2.62) and FROGS-health and treatment (effect size: 2) subscales. Conclusions: In this study, it was determined that as the symptoms of the illness increased in schizophrenia, the patients' functional remission and insight decreased, and their tendency to commit crimes increased. Psychiatric nurses can plan therapeutic interventions to increase the functionality and insight levels of patients with schizophrenia.
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    Evaluation of temperament/personality traits, alexithymia, psychiatric symptoms, and quality of life in female patients diagnosed with infertility
    (Cukurova Univ, Fac Medicine, 2020) Yildiz, Sevler; Ugur, Kerim; Sandogan, Erdinc; Yagin, Fatma Hilal; Akkus, Mustafa
    Purpose: The aim of this study was to compare the temperament/personality characteristics, alexithymia, psychiatric symptoms, and quality of life of a group of infertile women with the healthy control group, and thus to provide a basis for assessing the possible causal relationship between the phenomenon of infertility and these characteristics. Materials and Methods: Seventy-five women between 18-49 years of age who were diagnosed with infertility in the obstetrics outpatient clinic were included in the patient group and 75 healthy female individuals in the control group. Beck Depression Inventory, State Trait Anxiety Scale (STAI I-II), Quality of Life Scale, TEMPS Temperament Scale, and Toronto Alexithymia Scale were administered to all participants, and a semi-structured interview form was employed to question the clinical-sociodemographic characteristics. Results: Depression and anxiety scores of the patient group were higher than the control group's scores and the differences were statistically significant. The quality of life scale scores of the patient group were found to be lower in each sub-scale, and the differences were statistically significant. TheTemps-A sub-scales scores of the patient group were higher with statistically significant differences. Conclusion: Our findings support the need to investigate the possible accompanying psychosocial disorders in women receiving infertility treatment. The psychological support will be important for this group of women in terms of positively affecting the outcome during the treatment process
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    Serum HMGB1 and Beclin 1 Levels in Patients with a Diagnosis of Schizophrenia
    (Turkiye Sinir Ve Ruh Sagligi Dernegi, 2024) Yildiz, Sevler; Kilicaslan, Asli Kazgan; Emir, Burcu Sirlier; Ugur, Kerim; Kilic, Faruk
    Objective: It is known that inflammation plays a role in the etiopathogenesis of schizophrenia. In this study, we examined high mobility group box 1 protein (HMGB1) and Beclin 1 levels and their relationship with clinical variables in patients with schizophrenia. Method: Forty-three patients with schizophrenia and 43 healthy controls were included in this study. The patients were administered sociodemographic data form, the Positive Negative Symptoms Assessment Scale (PANSS) and the Clinical Global Impressions (CGI) scale. After the scales were filled, venous blood samples were taken from both the patient and control groups to measure serum HMGB1 and Beclin 1 levels. Serum samples obtained at the end of centrifugation were measured by Enzyme -Linked ImmunoSorbent Assay (ELISA) method. Results: The mean serum HMGB1 levels were significantly increased and the mean serum Beclin 1 levels were significantly decreased in the schizophrenia group compared to the control group. In addition, a negative correlation was found between HMGB1 and Beclin 1 levels. Conclusion: In conclusion, current research shows that HMGB1 is increased and Beclin 1 is decreased in patients with schizophrenia, and these findings may contribute to the role of autophagy in the pathogenesis of schizophrenia.