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Öğe 6 Şubat 2023 Kahramanmaraş Merkezli Depremlerden Etkilenen Depremzedelerde İntihar Girişimi, Dürtüsellik, Psikolojik Acı ve Depresyonun Araştırılması(2024) Sehlikoğlu, Kerem; Yildiz, Sevler; Kurt, Osman; Sehlikoğlu, Şeyma; Emir, Burcu SırlıerAmaç: 6 Şubat 2023 tarihli Kahramanmaraş merkezli depremlerden etkilenen depremzedelerden inti-har girişimi olan grupta bulunmayı öngören dürtüsellik, psikolojik acı, depresyon ve anksiyete düzeyleri-ni incelemekti. Materyal ve Metod: Ağustos 2023 ile Şubat 2024 arasında, intihar girişiminde bulunan 36 depremzede, bir psikiyatri kliniğinde vaka grubuna dahil edilmek üzere seçildi. Aynı zamanda, vaka grubu ile yaş ve cinsiyet açısından eşleştirilen ve psikiyatrik tanı almamış 36 depremzeden oluşan bir kontrol grubu oluşturuldu. Devamında her bir depremzede yarı yapılandırılmış sosyodemografik ve klinik veri formu, Beck Depresyon Ölçeği (BDÖ), Beck Anksiyete Ölçeği (BAÖ), Psikolojik Acı Ölçeği (PAÖ) ve Barratt Dürtüsellik Ölçeğini (BDÖ) doldurdu. Bulgular: İntihar girişiminde bulunan hastaların %63.9'u kadındı. Vaka grubundaki bireyler, kontrol gru-buna göre depremde daha fazla akraba kaybı yaşadı (p=0,002). Vaka grubunda, plan yapmama alt ölçeği ile BDÖ ve PAÖ arasında pozitif bir korelasyon vardı (sırasıyla r=0,691, p<0,001, r=0,370 p=0,026). İnti-har eyleminin depremle ilgili olup olmadığı açısından analiz edildiğinde, depremle ilgili intiharlarda daha az intihar geçmişi ve yöntem farkı olduğu gözlemlendi (sırasıyla p=0,006, p=0,029). Lojistik regres-yon analizine göre, yüksek PAÖ şiddeti, depremzedelerin intihar girişimi geçmişine sahip olma grubunda yer alacağını öngörmektedir (OR = 1,50, %95 CI: 1,17-1,94, p=0,01). Sonuç: Depresyon, dürtüsellik, anksiyete ve psikolojik acı belirtileri gösteren deprem sonrası hayatta kalanlar, intihar riski açısından yakından izlenmeli ve psikososyal müdahaleler sağlanmalıdır.Öğe The effect of functional remission and cognitive insight on criminal behavior in patients with schizophrenia(W B Saunders Co-Elsevier Inc, 2023) Polat, Hatice; Ugur, Kerim; Aslanoglu, Eren; Yildiz, Sevler; Yagin, Fatma HilalObjective: This study was planned to determine the relationship of functional remission with a criminal history and determine its effect on criminal behavior in patients with schizophrenia.Methods: This cross-sectional study was conducted with 132 patients with schizophrenia (66 with and 66 without a criminal history). Data were collected between November 2020 and April 2021 using a personal information form, the Functional Remission of General Schizophrenia (FROGS), the Taylor Crime Violence Rating Scale, the Beck Cognitive Insight Scale, and the Positive and Negative Syndrome Scale (PANSS) was used to collect data.Results: In terms of all scale variables, there were significant differences between the groups with and without a criminal history (p < 0.05). These differences were mostly clearly observed in the FROGS-social functionality (effect size: 16.79), PANSS-positive (effect size: 2.62) and FROGS-health and treatment (effect size: 2) subscales. Conclusions: In this study, it was determined that as the symptoms of the illness increased in schizophrenia, the patients' functional remission and insight decreased, and their tendency to commit crimes increased. Psychiatric nurses can plan therapeutic interventions to increase the functionality and insight levels of patients with schizophrenia.Öğe Evaluation of temperament/personality traits, alexithymia, psychiatric symptoms, and quality of life in female patients diagnosed with infertility(Cukurova Univ, Fac Medicine, 2020) Yildiz, Sevler; Ugur, Kerim; Sandogan, Erdinc; Yagin, Fatma Hilal; Akkus, MustafaPurpose: The aim of this study was to compare the temperament/personality characteristics, alexithymia, psychiatric symptoms, and quality of life of a group of infertile women with the healthy control group, and thus to provide a basis for assessing the possible causal relationship between the phenomenon of infertility and these characteristics. Materials and Methods: Seventy-five women between 18-49 years of age who were diagnosed with infertility in the obstetrics outpatient clinic were included in the patient group and 75 healthy female individuals in the control group. Beck Depression Inventory, State Trait Anxiety Scale (STAI I-II), Quality of Life Scale, TEMPS Temperament Scale, and Toronto Alexithymia Scale were administered to all participants, and a semi-structured interview form was employed to question the clinical-sociodemographic characteristics. Results: Depression and anxiety scores of the patient group were higher than the control group's scores and the differences were statistically significant. The quality of life scale scores of the patient group were found to be lower in each sub-scale, and the differences were statistically significant. TheTemps-A sub-scales scores of the patient group were higher with statistically significant differences. Conclusion: Our findings support the need to investigate the possible accompanying psychosocial disorders in women receiving infertility treatment. The psychological support will be important for this group of women in terms of positively affecting the outcome during the treatment processÖğe Inflammation markers in patients with psychotic disorder who have committed offenses and their relationship with criminal behavior(Routledge Journals, Taylor & Francis Ltd, 2025) Yildiz, Sevler; Emir, Burcu Sirlier; Kilicaslan, Asli Kazgan; Kurt, Osman; Ugur, Kerim; Sehlikoglu, Seyma; Atmaca, MuradThe role of inflammation in the etiology of psychotic disorders (PD) is well-established. This study aimed to identify inflammation parameters in patients diagnosed with PD, assess their potential as biomarkers, and examine their relationship with criminal behavior. This retrospective study comprised three groups: 530 patients diagnosed with PD who had committed crimes (offenders with PD), 530 patients with PD who had not committed crimes (non-offenders with PD), and 530 healthy controls, totaling 1,590 participants. Routine hematological tests were used to measure neutrophil, lymphocyte, monocyte, and platelet counts, high-density lipoprotein (HDL), systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), and neutrophil/HDL (NHR), lymphocyte/HDL, platelet/HDL (PHR), and monocyte/HDL (MHR) ratios. Offenders with PD exhibited significantly higher levels of SII, SIRI, PHR, NHR, LHR, neutrophils, and monocytes compared to non-offenders with PD and healthy controls (p < 0.001). The criminal group had lower HDL and lymphocyte levels than the remaining two groups (p < 0.001). Among those treated in forensic psychiatry units, patients with two or more treatments showed significantly higher SIRI values compared to those with only one treatment (p = 0.045). Non-offenders with PD had higher platelet values than the remaining two groups (p < 0.001). This study underscores the role of systemic inflammation in the pathophysiology of psychotic disorders through a comparison of patients who have and have not committed crimes, highlighting the relationship between inflammation and lipid metabolism. Further research is required to clarify these findings.Öğe Inflammatory markers and delirium in the intensive care unit(Mre Press, 2025) Yildiz, Sevler; Uslu, Muhammed Fuad; Emir, Burcu Sirlier; Kurt, OsmanBackground: Delirium is an important complication in patients admitted to intensive care unit (ICU). However, delirium prediction in patients admitted to the ICU is difficult. Considering the role of neuroinflammation in delirium, peripheral blood-based biomarkers of inflammation pressure could predict delirium. The aim of study was to retrospectively analyze ratios of neutrophil/high density lipoprotein (HDL) (NHR), lymphocyte/HDL (LHR), platelet/HDL (PHR), monocyte/HDL (MHR), as well as systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) in ICU patients diagnosed with delirium. Methods: The study included a total of 2141 patients with or without delirium. The risk factors for delirium development and the predictive power of individual laboratory parameters were evaluated with the Pearson chi-square test, Mann-Whitney U test, Spearman correlation test, logistic regression, and receiver operating characteristic analyses. Results: Length of ICU stay (p < 0.001), NHR (p = 0.035), LHR (p < 0.001), PHR (p = 0.047), MHR (p < 0.001), SIRI (p < 0.001), and SII (p < 0.001) were significantly higher in patients who developed delirium compared to those who did not. A significant negative correlation was found between the duration of delirium and SII (r = -0.260; p = 0.004). Older age, a history of psychiatric treatment, prolonged hospitalization, and high LHR, SIRI, and SII values were determined as risk factors for delirium (p < 0.05 for all). Conclusions: Elevated LHR, SIRI, and SII levels before ICU admission are associated with an increased risk of hyperactive delirium. If confirmed by prospective evidence, readily available biomarkers for inflammation could be used to evaluate the hyperactive delirium risk in ICUs.Öğe Investigation of social support perceptions and mental health of postpartum women following the February 6, 2023 Turkey earthquake: a comparative study(Springer, 2025) Sehlikoglu, Seyma; Bekircan, Esra; Cicek, Sevil; Kurt, Osman; Yildiz, Sevler; Simsek, Yavuz; Emir, Burcu SirlierNatural disasters, such as earthquakes, have significant psychological consequences, particularly for vulnerable populations like postpartum women. This study aimed to determine the relationship between perceived social support and mental health among postpartum women who had experienced an earthquake. In this comparative cross-sectional study, the case group (n = 62) consisted of women who were in their third trimester at the time of the earthquake and gave birth after the disaster, while the control group (n = 62) comprised women who were also in their third trimester during the earthquake and had given birth but were not residing in the earthquake-affected region and had no prior experience of an earthquake. The study did not include individuals with intellectual disabilities, illiteracy. Data were collected using the Sociodemographic data form, the Edinburgh Postnatal Depression Scale, the Multidimensional Scale of Perceived Social Support (MSPSS), the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5), and the Post-Traumatic Growth Inventory (PTGI). The incidence rates of Posttraumatic Stress Disorder (40.3%) and Edinburgh Postnatal Depression Scale (43.5%) in postpartum women who experienced the earthquake were significantly higher than those in women who did not (Posttraumatic stress disorder: 6.5%, Edinburgh Postnatal Depression Scale: 16.1%) (p <.001). The mean total MSPSS score of postpartum women who experienced the earthquake (61.7 +/- 16.9) was significantly higher than that of those who did not (51.9 +/- 13.2) (p <.001). The mean PTGI total score in postpartum women who experienced the earthquake (69.0 +/- 19.2) was significantly higher than in the control group (57.3 +/- 20.0) (p <.001). In postpartum women who experienced the earthquake, there was a significant positive correlation between PTGI and MSPSS scores, and between PCL-5 and Edinburgh Postnatal Depression Scale scores (p <.001). Pregnant women who experienced the earthquake had significantly higher posttraumatic stress disorder and postpartum depression scores compared to those who did not. It was concluded that perceived social support may promote posttraumatic growth in women who have experienced a postpartum earthquake.Öğe Investigation of social support perceptions and mental health of postpartum women following the February 6, 2023 Turkey earthquake: a comparative study (Vol 44, pg 13887, 2025)(Springer, 2025) Sehlikoglu, Seyma; Bekircan, Esra; Cicek, Sevil; Kurt, Osman; Yildiz, Sevler; Simsek, Yavuz; Emir, Burcu Sirlier[No abstract available]Öğe Markers of inflammation in patients with generalized anxiety disorder(Cukurova Univ, Fac Medicine, 2024) Yildiz, Sevler; Kilicaslan, Asli Kazgan; Emir, Burcu Sirlier; Tabara, Muhammed Fatih; Kurt, Osman; Sehlikoglu, Seyma; Ugur, KerimPurpose: The aim of this study was to analyze the systemic immune response index, systemic immune inflammation platelet/HDL, and monocyte/HDL ratio, used as inflammatory markers in patients with generalized anxiety Materials and Methods: A total of 864 participants, including 432 healthy controls and 432 patients diagnosed with GAD, were included in this study. High-density lymphocyte, and platelet counts; systemic inflammatory calculated. contributing to both diagnosis and management.Öğe Serum HMGB1 and Beclin 1 Levels in Patients with a Diagnosis of Schizophrenia(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2024) Yildiz, Sevler; Kilicaslan, Asli Kazgan; Emir, Burcu Sirlier; Ugur, Kerim; Kilic, FarukObjective: It is known that inflammation plays a role in the etiopathogenesis of schizophrenia. In this study, we examined high mobility group box 1 protein (HMGB1) and Beclin 1 levels and their relationship with clinical variables in patients with schizophrenia. Method: Forty-three patients with schizophrenia and 43 healthy controls were included in this study. The patients were administered sociodemographic data form, the Positive Negative Symptoms Assessment Scale (PANSS) and the Clinical Global Impressions (CGI) scale. After the scales were filled, venous blood samples were taken from both the patient and control groups to measure serum HMGB1 and Beclin 1 levels. Serum samples obtained at the end of centrifugation were measured by Enzyme -Linked ImmunoSorbent Assay (ELISA) method. Results: The mean serum HMGB1 levels were significantly increased and the mean serum Beclin 1 levels were significantly decreased in the schizophrenia group compared to the control group. In addition, a negative correlation was found between HMGB1 and Beclin 1 levels. Conclusion: In conclusion, current research shows that HMGB1 is increased and Beclin 1 is decreased in patients with schizophrenia, and these findings may contribute to the role of autophagy in the pathogenesis of schizophrenia.Öğe Technology Addiction and Social Connectedness in Psychiatric Illness: A Multicenter Study(Korean Neuropsychiatric Assoc, 2024) Kurt, Osman; Tabara, Muhammed Fatih; Yildiz, Sevler; Kilicaslan, Asli Kazgan; Emir, Burcu Sirlier; Oktay, Meltem; Cansel, NeslihanObjective: Technology addiction is an increasingly important public health problem all over the world that negatively affects people's mental and physical health. In this study, we examined technology addiction and social connectedness levels of psychiatric patients who admitted to clinics in different geographical regions of Turkey. Methods: A total of 642 people with a diagnosis of psychiatric illness who applied to psychiatry clinics in & Idot;stanbul, Elazig, Malatya, Yozgat, Ad & imath;yaman, and Bingol provinces were included. Sociodemographic data form, Technology Addiction Scale (TAS), and Social Connectedness Scale (SCS) were applied to all participants. Results: The total score of the TAS in patients diagnosed with anxiety disorder and somatoform disorder was significantly higher than the other patient groups (p<0.001). Patients diagnosed with anxiety disorder showed a significant difference from other patient groups in terms of SCS score (p<0.001). Anxiety disorder was found to be the highest in TAS total score and sub-dimensions and the lowest in SCS score, while major depressive disorder was found to be the lowest in TAS total score and sub-dimensions and the highest in SCS score. The multiple linear regression analysis showed that the total score of the TAS was predicted by the SCS score (beta=-1.857, p<0.001) and the SCS score was predicted by age (beta=0.046, p=0.049) and the total score of the TAS (beta=-0.316, p<0.001). Conclusion: As a result of this study, we can say that psychiatric patients have a moderate level of technology addiction, these people have high levels of social connectedness, and psychiatric patients with technology addiction have a high level of social belonging.
