Yazar "Yildiz A." seçeneğine göre listele

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    Investigation of the Effect of Astaxanthin on Autophagy in Renal Ischemia-reperfusion Modeled Rats
    (Galenos Publishing House, 2024) Kisaoglu A.; Kose E.; Yilmaz N.; Tanbek K.; Yildiz A.; Yilmaz U.; Cirik R.H.
    Objective: The aim of this study was to investigate the effect of various astaxanthin (ATX) doses on oxidative damage and autophagy in renal ischemia-reperfusion (I/R) injury-modeled rats. Methods: The rats were divided into five groups: sham group (n=8), I/R (n=8), I/R + 5 mg/kg ATX (n=8), I/R + 10 mg/kg ATX (n=8), and I/R + 25 mg/ kg ATX (n=8) groups. ATX was dissolved in 5 mg/kg, 10 mg/kg, and 25 mg/ kg olive oil for 7 days and administered to the rats in the experimental group. Sham and I/R groups were also administered ATX solution (olive oil) via oral gavage for 7 days. Renal ischemia reperfusion was induced in all rats except the sham group after the last dose was administered on the 7th day. Reperfusion was conducted for 24 hours after 45 minutes of ischemia. Results: Blood samples were collected, and kidney tissue were incised for biochemical and histological analyses. Superoxide dismutase (SOD) and total antioxidant status (TAS) were significantly lower in the I/R group than in the sham group (p<0.05), whereas malondialdehyde (MDA) and total oxidant status (TOS) values were higher (p<0.05). It was determined that SOD and TAS increased and MDA and TOS decreased in the ATX-administration groups compared with the I/R group, independent of the dose (p<0.05). In the 25 mg/kg ATX + I/R group, Beclin-1 and LC3? immunoreactivities were significantly higher than those in the other groups (p<0.05). The lowest p62 immunoreactivity was observed in the 25 mg/kg ATX + I/R group. Conclusions: ATX had a protective effect on kidney function and against oxidative damage. Furthermore, high-dose ATX administration protected kidney tissue via autophagy induction in this study. © 2024 The Author.
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    An investigation of the effects of duloxetine on the heart
    (OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2020) Eranil I.; Vardi N.; Yildiz A.; Parlakpinar H.; Özhan O.
    Objevtive: The present study was designed to examine the effects of high dose and low dose duloxetine on Cx43, a gap junction (GJ) protein; on S100A, cardiac contractility component and on certain early cardiac impairment parameters as TnI and TnT. Material and Methods: The study was performed with 24 male Wistar Albino rats by generating control group (1 ml solvent), low-dose duloxetine (LDD) group (10 mg/kg) and high-dose duloxetine (HDD) group (100 mg/kg). After the experimental procedure, the results concerning blood pressure and heart rates of the anesthetized rats were recorded and HE staining and immunostaining of Cx43, S100A, TnI and TnT were applied to the heart tissue sections. Results: In the control group, Cx43 was stained as marked streaks between cardiomyocytes; TnI, TnT and S100A were stained as homogenous and dark brown in cytoplasm. Nevertheless, intensity of Cx43 immunostaining showed significant increase in duloxetine- treated groups (p<0.001). TnT (p=0.024, p=0.004, p<0.05) and S100A (p<0.001) immunostaining were low in high dose group compared to control group and low dose group. TnI immunostaining also demonstrated significant decrease in high dose duloxetine group as compared to the control group (p<0.001). There was no statistically significant difference between groups in terms of heart rate, ECG parameters, MDA, SOD, GSH and CAT levels (p>0.05). Conclusion: Our study reveals that duloxetine induced an increase in the immunostaining of Cx43, and a decrease in the immunostaining of TnI, TnT and S100A, also known as early cardiac parameters. Furthermore, duloxetine was observed to show no effect on oxidant and antioxidant parameters. While heart rate remained unchanged, mean blood pressure decreased in high dose duloxetine group. In the light of the study outcomes, it has been concluded that antidepressants must be administered more advertently in depression patients with heart disorders. © 2020 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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    On a class of generalized sasakian-space-forms
    (Univerzita Komenskeho, 2018) Majhi P.; De U.C.; Yildiz A.
    The object of the present paper is to study quasi-conformally at generalized Sasakian-space-forms. Also we study quasi-conformally semisymmetric generalized Sasakian-space-forms. As a consequence of the results, we obtain some important corollaries. © 2018, Univerzita Komenskeho. All rights reserved.
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    On a type of lorentzian Para-Sasakian manifolds
    (Editura Academiei Romane, 2014) Yildiz A.; De U.C.; Ata E.
    The object of the present paper is to introduce a new concept called generalized ?-Einstein manifold in a Lorentzian Para-Sasakian manifold. Some geometric properties have been studied. Finally an example has been constructed to prove the existance of a generalized ?-Einstein Lorentzian Para-Sasakian manifold.
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    ON RICCI TENSOR IN THE GENERALIZED SASAKIAN-SPACE-FORMS
    (Bayram Sahin, 2019) Chaubey S.K.; Yildiz A.
    The object of the present paper is to study the properties of generalized Sasakian-space-forms. We prove the results related to Ricci symmetric, Ricci recurrent, cyclic parallel and Codazzi type Ricci tensors. Results on Ricci soliton and gradient Ricci soliton are proved. Also, we provide the examples of generalized Sasakian-space-forms which are verified our results. © 2019, Bayram Sahin. All rights reserved.
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    ON TRANS-SASAKIAN 3-MANIFOLDS WITH RESPECT TO THE SCHOUTEN-VAN KAMPEN CONNECTION
    (Bayram Sahin, 2021) Zeren S.; Yildiz A.
    The object of the present paper is to characterize trans-Sasakian 3-manifolds with respect to the Schouten-van Kampen connection. Also, we consider Ricci solitons, ?-Ricci solitons and Yamabe solitons of a trans-Sasakian 3-manifold with respect to the Schouten-van Kampen connection. Then we give an example of a trans-Sasakian 3-manifold with respect to the Schouten-van Kampen connection. © 2021, Bayram Sahin. All rights reserved.
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    Some curvature conditions on n(k)-quasi-einstein manifolds
    (Universitatii Al.I.Cuza din Iasi, 2016) De U.C.; Yildiz A.; Mallick S.
    The object of the present paper is to study N(k)-quasi-Einstein manifolds. Existence of N(k)-quasi Einstein manifolds is proved by a non-trivial example. Also some physical examples of N(k)-quasi-Einstein manifolds are given. We study an N(k)-quasi-Einstein manifold satisfying the curvature conditions C(?, X) · R = 0, R(?, X) · (formula present) = 0, and W (?, X) · S = 0, where R, C, (formula present) and S denote the Riemannian curvature tensor, the conformal curvature tensor, m-projective curvature tensor and Ricci tensor respectively. © 2016, Universitatii Al.I.Cuza din Iasi. All rights reserved.