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Öğe Ameliorative effects of curcumin against acute cadmium toxicity on male reproductive system in rats(Wiley, 2012) Oguzturk, H.; Ciftci, O.; Aydin, M.; Timurkaan, N.; Beytur, A.; Yilmaz, F.The aim of the present study was to investigate the ameliorative effect of curcumin (CMN) against acute cadmium chloride (CdCl2) toxicity on male reproductive system in rats. CdCl2 is known to be a heavy metal and potential environmental pollutant. For this purpose, 28 rats were equally divided into four groups; the first group was kept as control and given distilled water and corn oil as carrier. In second and third groups, CdCl2 and CMN were administered at the dose with 1 mg kg-1 day-1 and 100 mg kg-1 for 3 days respectively. CdCl2 and CMN were given together at the same doses in the fourth group. It was determined that acute CdCl2 exposure caused a significant reproductive damage via increased oxidative stress (increased TBARS levels and decreased SOD, CAT, GPx and GSH levels), histological alterations (necrosis, oedema etc.) and spermatological damage (decreased sperm motility and sperm concentration and increased abnormal sperm rate) in male rats. However, CMN treatment partially reversed these toxic effects of CdCl2 on the reproductive system. In conclusion, our results show that acute exposure of CdCl2 may lead to infertility, and CMN could prevent and reverse hazardous effects of CdCl2 to some degree. Thus, CMN may be useful for the prevention of CdCl2-induced reproductive damage.Öğe The clinicopathological features and survival of Castleman disease: a multicenter Turkish study(Verduci Publisher, 2022) Yildiz, J.; Bagci, M.; Sayin, S.; Kaya, A.; Yilmaz, F.; Ekinci, O.; Dal, M. S.OBJECTIVE: In this study, we aimed to investigate the clinicopathological features and survival of CD, which is quite rare and has many unknowns. PATIENTS AND METHODS: This study was conducted by retrospectively evaluating patients diagnosed with CD in six different centers in Turkey. RESULTS: The median age of 33 patients included in the study was 49 and 51.5% (n = 17) of these patients were women. 18 (54.5%) patients were in the hyaline vascular subtype and most of the patients were UCD (n = 20, 60.6%). The most common involvement region was head and neck (n = 19, 57.5%). The UCD group was younger than the MCD group (p=0.027). Visceral lymph node involvement was higher in MCD than in UCD (p=0.001). Similarly, it was observed that there was more hepatomegaly (p=0.035) and splenomegaly (p=0.013) in the MCD group. During the median 19.5 months follow-up period, there were no patients who died. CONCLUSIONS: It was observed that UCD and MCD are different clinical entities. Promising survival times can be achieved with surgical and systemic treatments in both subtypes of this extremely rare disease. However, this re- suit should be supported by well-designed prospective comprehensive studies.Öğe EFFICACY AND SAFETY OF RUXOLITINIB IN TURKISH PATIENTS WITH CHRONIC MYELOPROLIFERATIVE NEOPLASMS: A MULTICENTER AND RETROSPECTIVE ANALYSIS(Pergamon-Elsevier Science Ltd, 2017) Soyer, N.; Turgut, M.; Haznedaroglu, I.; Yilmaz, F.; Aydogdu, I.; Pir, A.; Karakus, V.[Abstract Not Available]Öğe Nanoindentation Properties of HTc Superconducting Single-Crystalline Whiskers(Springer, 2013) Kizilaslan, O.; Yilmaz, F.; Aksan, M. A.; Yakinci, M. E.In this work, superconducting and mechanical properties of BSCCO superconducting whiskers were studied in detail. Nanoindentation properties of the whiskers were analyzed by the Oliver and Pharr Method and Work of Indentation (WI) method. More accurate results using the WI method for both the hardness and the reduced modulus were obtained due to reduction of the pile-up error. The correct hardness and reduced modulus values were determined by considering the indentation size effect and the substrate (epoxy resin) effect. The modified composite hardness model and the composite reduced modulus model are the most suitable models to investigate the nanoindentation properties of the whiskers.Öğe Protocatechuic acid prevents reproductive damage caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in male rats(Wiley, 2012) Beytur, A.; Ciftci, O.; Aydin, M.; Cakir, O.; Timurkaan, N.; Yilmaz, F.In this study, it was aimed to determinate beneficial effects of protocatechuic acid (PCA) against reproductive toxicity caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant. For this purpose, 28 rats were equally divided into four groups (control, TCDD 2 mu g kg-1 per week, PCA 100 mg kg-1 per day and TCDD + PCA group), and compounds were orally administered for 45 days. The results indicated that TCDD induced oxidative stress via an increase in thiobarbituric acid-reactive substances levels and a decrease in reduced glutathione, catalase, glutathione peroxidise and SOD levels in male rats. In contrast, PCA treatment prevented toxic effects of TCDD in terms of oxidative stress. Additionally, sperm motility, sperm concentration and serum testosterone levels significantly decreased, and pathologic testicular damage increased with TCDD exposure. However, these effects of TCDD on sperm characteristics, histopathological changes and hormone levels were reversed by PCA treatment. In conclusion, it was found that TCDD exposure induced reproductive toxicity (oxidative, hormonal, histopathological and spermatological alternations) in male rats and PCA treatment could prevent toxic effects of TCDD. Thus, PCA may be useful for the prevention and treatment of reproductive toxicity caused by TCDD.Öğe Retrospective and multicenter analysis of efficacy and safety of ruxolitinib in 176 Turkish patients with myelofibrosis: updated data(Pergamon-Elsevier Science Ltd, 2018) Soyer, N.; Ali, R.; Turgut, M.; Haznedaroglu, I.; Yilmaz, F.; Aydogdu, I.; Pir, A.[Abstract Not Available]
