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Öğe Acute oak (Quercus infectoria) toxicosis in lambs(Ecole Nationale Veterinaire Toulouse, 2013) Eroksuz, Y.; Dabak, M.; Eroksuz, H.; Baydar, E.; Turkoglu, I.; Yilmaz, I.Acute intoxication caused by consumption of oak (Quercus infectoria subsp. boissieri) occurred in a flock of 92 lambs in Elazig, a province of the eastern Turkey. Four lambs had died with a history of anorexia and recumbency following introduction approximately 150 g per animal/day oak material for 10-13 days. Clinical, pathological and biochemical findings were documented in 3 lambs. The most striking biochemical changes were detected in blood urea nitrogen levels and gamma-glutamyl transferase activity. At necropsy; subcutaneous edema, mild hydrothorax, moderate ascites, severe perirenal and retroperitoneal edema, severe multifocal renal subcapsular petechiation were the major gross findings detected in all cases. Renal histopathology revealed moderate multifocal tubular cell necrosis, multifocal moderate cell swelling, multifocal tubular dilatation and hyaline cast formations. The results of this study suggest that both plant and animal based factors; namely the young age and high tannin content might contribute to the occurrence of the present toxicosis in the lambs.Öğe The defensive effects of synthetic organoselenium compounds on the antioxidative system of DMBA induced rat brain(Blackwell Publishing, 2006) Talas, Z. Selamoglu; Yilmaz, I.; Ozdemir, I.; Gok, Y.; Orun, I.; Cetinkaya, B.[Abstract Not Available]Öğe Effect of chemotherapy exposure prior to pregnancy on fetal brain tissue and the potential protective role of quercetin(Springer, 2015) Dogan, Z.; Kocahan, S.; Erdemli, E.; Kose, E.; Yilmaz, I.; Ekincioglu, Z.; Ekinci, N.Cyclophosphamide (CYC) and doxorubicin (DOX) are among the most effective and widely used anticancer chemotherapeutic drugs. Potential chemopreventive and chemotherapeutic functions have recently been attributed to flavonoids. We hypothesized that Quercetin (QR) would protect against the toxic effects of chemotherapeutic agents applied prior to pregnancy. Rats were treated with the chemotherapeutic drugs CYC (27 mg/kg) and DOX (1.8 mg/kg) applied in a single intraperitoneal dose once every 3 weeks for 10 weeks. QR was administered at a dose of 10 mg/kg/day by oral gavage. 48 h following the experimental chemotherapy exposure, female rats were transferred to cages containing male rat for mating. Fetal brain tissues were removed from fetuses extracted by cesarean section on the 20th day of gestation for evaluation of antioxidant parameters. A significant increase in superoxide dismutase and malondialdehyde activity was observed in CYC and DOX treatment groups relative to the control group (p < 0.05). Similarly, carnitine acylcarnitine translocase and Glutathione activity was significantly reduced in the CYC and DOX groups relative to the control group (p < 0.05). Our results indicate that the use of chemotherapeutic drugs before pregnancy can result in oxidative damage to fetal brain tissue. Therefore, women who have been exposed to chemotherapy and may become pregnant should be treated with antioxidant compounds such as QR to reduce the risk of damage to fetal brain tissues.Öğe Effects of Organic Apricot on Liver Regeneration After Partial Hepatectomy in Rats(Elsevier Science Inc, 2013) Yilmaz, I.; Karaman, A.; Vardi, N.; Cetin, A.; Erdemli, E.Background. The present study investigated the effects of (sun-dried organic apricot/SDOA) supplementation in chow on liver regeneration after partial hepatectomy/(PH) in rats. Method. In this study, 28 female rats were randomized into four groups. On the 7th day of the study, group 1 underwent laparoscopic intervention while a PH was performed on the other three cohorts. On day 28, all rats were humanely killed. Blood and liver tissue samples were subjected to biochemical determinations, histological examinations, and measurement of tissue oxidative stress enzyme activity. Results. Serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP), and liver tissue glutathione (GSH) activities were affected by PH and/or SDOA consumption (P < .05). Moderately staining cell counts in group 4 were significantly different from the other three groups (P < .05). However, no significant differences were detected among all groups in regard to aspartate aminotransferase (AST) serum levels or liver tissue superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT) or glutathione peroxidase (GSHpx) activities (P < .05). Conclusion. The 5% SDOA supplementation over a 21-day feeding period showed a beneficial effect on liver regeneration in rats, as reflects by Ki-67 finding although there was no change in ALT or ALP or in liver tissue GSH activity.Öğe The effects of selenium on rainbow trout liver treated with heavy metals(Blackwell Publishing, 2006) Talas, Z. Selamoglu; Orun, I.; Alkan, A.; Ozdemir, I.; Erdogan, K.; Yilmaz, I.[Abstract Not Available]Öğe Modulation of DMBA-induced biochemical changes by organoselenium compounds in. blood of rats(Natl Inst Science Communication-Niscair, 2007) Ozdemir, I.; Selamoglu, Z.; Ates, B.; Gok, Y.; Yilmaz, I.The protective role of two synthetic organoselenium compounds 1-isopropyl-3-methylbenzimidazole-2-selenone (SeI) and 1, 3-di-p-methoxybenzylpyrimidine-2-selenone (Sell) was examined against the 7,12-dimethylbenz[a]anthracene (DMBA)-induced changes in biochemical parameters in blood of rats. Albino Winstar rats (150-200 g body wt) were treated with single dose of DMBA (50 mg/kg body wt) and organoselenium compounds (25 mu mol/kg) for 4 weeks at two days internal. Blood was taken from the anaesthetized rats ventricle from their hearts for biochemical analysis. Administration of DMBA resulted in elevation of urea, uric acid and creatinine levels as well as AST, ALT and LDH activities and decrease in levels of total proteins, albumin and globulin. Set and Sell caused I significant (p<0.05) decrease ill Urea, uric acid and creatinine levels and alanine aminotransferase (ALT); aspartate aminotransferase; (AST) and lactate dehydrogenase (LDH) activities and significantly increased the levels of total protein and albumin (p<0.05). These organoselenium compounds are likely to be beneficial in human health.Öğe Mono- and dinuclear Pd(II) complexes of different salicylaldimine ligands as catalysts of transfer hydrogenation of nitrobenzene with cyclohexene and Suzuki-Miyaura coupling reactions(Elsevier Science Sa, 2009) Tas, E.; Kilic, A.; Durgun, M.; Yilmaz, I.; Ozdemir, I.; Gurbuz, N.In this study, the synthesis, spectroscopic, catalytic, and electrochemical properties of salicylaldimine Schiff-base ligands (L-n) and their dinuclear Pd(II) complexes for L-1 and L-2 ligands with mononuclear Pd(II) complexes for L-3 and L-4 ligands were investigated. The ligands and their mono- or dinuclear Pd(II) complexes were characterized by FT-IR, UV-Vis, H-1 NMR and elemental analysis, as well as through magnetic susceptibility and spectroelectrochemical techniques. The catalytic studies showed that the introduction of tert butyl groups on the salicyl ring of the molecules increased the catalytic activity towards hydrogenation of nitrobenzene and cyclohexene in DMF at 25 and 45 degrees C. It was also observed that the steric hindered mono- and dinuclear Pd( II) complexes were thermally stable complexes and were not sensitive to air or the moisture. The complexes were easily prepared from cheap materials that could be used as versatile and efficient catalysts for different C-C coupling reactions (Suzuki-Miyaura reactions). (C) 2008 Elsevier B.V. All rights reserved.Öğe Production of L-asparaginase, a chemotherapeutic enzyme, in bacteria expressing Vitreoscilla haemoglobin(Blackwell Publishing, 2006) Ates, B.; Gencer, S.; Erenler, S. O.; Uckun, M.; Ozer, U.; Yilmaz, I.; Geckil, H.[Abstract Not Available]Öğe The silencing of PDGF-B pathway by Chitosan/siRNA nanoplexes in therapy of the experimental mesangial proliferative glomerulonephritis(Mary Ann Liebert, Inc, 2016) Salva, E.; Alan, S.; Yilmaz, I.; Turan, S. O.; Akbuga, J.[Abstract Not Available]
