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  • Küçük Resim
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    Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?
    (2020) cekici, Yusuf; Sincer, Isa; Kaplangoray, Mustafa; Yilmaz, Mucahid; Yildirim, Arafat
    Aim: Several studies have found a correlation between coronary slow flow (CSF) and low serum high-density lipoprotein cholesterol (HDL-C) levels or high serum uric acid levels. The present study aimed to evaluate whether serum uric acid to HDL-C ratio predicts CSF.Material and Methods: The experimental (CSF) group included 91 patients (40 females, 51 males, mean age: 52±9) who had angiographically normal coronary arteries but had slow flow in one or more coronary arteries. The control group included 96 patients (57 females, 39 males, mean age: 50±9) with normal coronary anatomy and without slow flow. The uric acid to HDL-C ratio was calculated for the two groups and compared.Results: The HDL-C levels of the CSF group (37±8 mg/dL) were significantly lower compared to the controls (49±10 mg/dL, p0.001), whereas serum uric acid levels (5.33±0.97 mg/dL) and uric acid to HDL-C ratio (0.14±0.03) of the CSF group were significantly higher compared to the controls (4.37±0.88 mg/dL and 0.09±0.02, p0.001 and p4.64 mg/dL uric acid and >0.119 % uric acid to HDL-C ratio had a sensitivity of 81% and 85% and specificity of 76% and 80% for determination of CSF, respectively (AUC=0.850, 95% CI: 0.792 - 0.908 and AUC=0.890, 95% CI: 0.841 - 0.940,respectively).Spearman's correlation test has been performed and a significant positive correlation has been detected between the uric acid to HDL-C ratio and the mean thrombolysis in myocardial infarction (TIMI) frame count (r=0.62, p0.001).Conclusion: In this study, higher uric acid to HDL-C ratio values of the CSF group was found compared to the control group. Furthermore, uric acid to HDL-C ratio performed better than serum uric acid levels in predicting CSF.
  • Küçük Resim
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    Evaluation of Tpe-interval and Tpe/QT, Tpe/QTc ratios in patients with premature ovarian failure
    (2019) cekici, Yusuf; Kilic, Salih; Saracoglu, Erhan; Ovayolu, Ali; Yilmaz, Mucahid; Duzen, Veysel Irfan
    Aim: Ventricular repolarization were evaluated in patients who had POF by using novel electrocardiographic parameters including Tpe-interval and Tpe/QT and Tpe/QTc ratios. A few studies have investigated the association between premature ovarian failure (POF) and cardiovascular diseases. However, none have examined ventricular repolarization in this respect.Materials and Methods: This cross-sectional study included 60 female patients with POF (mean 32.6±4.7 years) and 54 control healthy female subjects (mean 30.9±4.6 years).All electrocardiogram (ECG) measurements were performed by a cardiologist using a computer, and the Tpe-interval, Tpe/QT, and Tpe/QTc were compared between groups.Results: There were no significant differences between groups in terms of baseline characteristics and laboratory parameters. The Tpe-interval, Tpe/QT, and Tpe/QTc were significantly prolonged in POF group than control subjects (p0.001 for all). There was a strong and positive correlation between the serum follicle-stimulating hormone (FSH) level and Tpe-interval (r=0.681; p0.001) and Tpe/QTc (r= 0.636; p0.001). Furthermore, high and negative correlation was found between serum estradiol and Tpe-interval (r=-0.531; p0.001) and Tpe/QTc (r=-0.510). Multivariate linear regression analysis showed that that the FSH and estradiol level were independent predictors of both the Tpe-interval (B=0.541 and p0.001, B=-0.202 and p0.001, respectively) and Tpe/QTc (B=0.442 and p0.001, B= -0.239 and p0.001, respectively).Conclusion: It was concluded in the study that ECG parameters of ventricular repolarization, namely, Tpe-interval, Tpe/QT, and Tpe/QTc were significantly prolonged in patients that had POF.