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    Adolescence-onset atypical hemolytic uremic syndrome: is it different from infant-onset?
    (Springer, 2024) Celegen, Kubra; Gulhan, Bora; Fidan, Kibriya; Yuksel, Selcuk; Yilmaz, Neslihan; Yilmaz, Aysun Caltik; Kilic, Beltinge Demircioglu
    Background: Atypical hemolytic uremic syndrome (aHUS) is a rare, mostly complement-mediated thrombotic microangiopathy. The majority of patients are infants. In contrast to infantile-onset aHUS, the clinical and genetic characteristics of adolescence-onset aHUS have not been sufficiently addressed to date. Methods: A total of 28 patients (21 girls, 7 boys) who were diagnosed as aHUS between the ages of >= 10 years and <18 years were included in this study. All available data in the Turkish Pediatric aHUS registry were collected and analyzed. Results: The mean age at diagnosis was 12.8 +/- 2.3 years. Extra-renal involvement was noted in 13 patients (46.4%); neurological involvement was the most common (32%). A total of 21 patients (75%) required kidney replacement therapy. Five patients (17.8%) received only plasma therapy and 23 (82%) of the patients received eculizumab. Hematologic remission and renal remission were achieved in 25 (89.3%) and 17 (60.7%) of the patients, respectively. Compared with the infantile-onset aHUS patients, adolescent patients had a lower complete remission rate during the first episode (p = 0.002). Genetic analyses were performed in all and a genetic variant was detected in 39.3% of the patients. The mean follow-up duration was 4.9 +/- 2.6 years. At the last visit, adolescent patients had lower eGFR levels (p = 0.03) and higher rates of chronic kidney disease stage 5 when compared to infantile-onset aHUS patients (p = 0.04). Conclusions: Adolescence-onset aHUS is a rare disease but tends to cause more permanent renal dysfunction than infantile-onset aHUS. These results may modify the management approaches in these patients.
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    Adolescence-onset atypical hemolytic uremic syndrome: is it different from infant-onset? (MAY, 10.1007/s10157-024-02505-7, 2024)
    (Springer, 2024) Celegen, Kubra; Gulhan, Bora; Fidan, Kibriya; Yuksel, Selcuk; Yilmaz, Neslihan; Yilmaz, Aysun Caltik; Kilic, Beltinge Demircioglu
    [Abstract Not Available]
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    CLINICAL COURSE OF ADOLESCENT ONSET ATYPICAL HEMOLYTIC UREMIC SYNDROME: A STUDY OF TURKISH AHUS REGISTRY
    (Springer, 2022) Celegen, Kubra; Gulhan, Bora; Fidan, Kibriya; Yuksel, Selcuk; Yilmaz, Neslihan; Yilmaz, Aysun Caltik; Kilic, Beltinge Demircioglu
    [Abstract Not Available]
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    EFFECTS OF MUSIC-BASED INSTRUCTION ON PHONOLOGICAL AWARENESS IN PRESCHOOL CHILDREN
    (Tolga Karaca, 2026) Duran, Munise; Yilmaz, Neslihan
    The purpose of this study is to examine the impact of structured musical activities on phonological awareness skills in early childhood. A quasi-experimental pretest–posttest control group design was employed with 52 children aged 5-6 years. The experimental group received an eight-week structured music-based intervention program including rhythm–syllable matching, melodic repetition, pitch discrimination, prosodic practice, and tempo perception activities. Data were collected using the Mountain Shadows Phonemic Awareness Scale (MS-PAS), and analyses were conducted via Mann-Whitney U and Wilcoxon tests. The findings indicated a significant increase in the experimental group’s phonological awareness scores, whereas no significant change was observed in the control group. The results suggest that musical are an effective tool in improving phonological awareness and supporting emergent literacy skills in early childhood. © 2026, Tolga Karaca. All rights reserved.