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Öğe Does apelin-13 affect the development of brown fat?(Wiley-Blackwell, 2014) Yilmaz, U.; Erden, Y.; Tekin, S.; Etem, E.; Sandal, S.[Abstract Not Available]Öğe THE EFFECT OF MELATONIN ON THE EXPERIMENTALLY PRODUCED ALZHEIMER IN RATS AND RELATIONSHIP WITH FEZ1 GENE EXPRESSION(Wiley, 2017) Demir, M.; Yilmaz, U.; Sandal, S.; Colak, C.; Cigremis, Y.; Tekedereli, I.[Abstract Not Available]Öğe EFFECTS OF INTRACEREBROVENTRICULAR FGF21 INFUSION ON THE ENERGY METABOLISM(Wiley, 2017) Yilmaz, U.; Tekin, S.; Demir, M.; Cigremis, Y.; Sandai, S.[Abstract Not Available]Öğe EFFECTS OF SHORT-TERM AND LONG-TERM OF OBESITY ON RETN, IAPP, and DRD5 MRNA LEVELS(Wiley, 2017) Kahraman, O. Timirci; Yilmaz, U.; Horozoglu, C.; Cevik, A.; Celik, F.; Gokce, M. O.; Ergen, A.[Abstract Not Available]Öğe Is there a new pathway relationship between melatonin and FEZ1 in experimental rat model of Alzheimer's disease?(Comenius Univ, 2019) Demir, M.; Yilmaz, U.; Colak, C.; Cigremis, Y.; Ozyalin, F.; Tekedereli, I; Sandal, S.Alzheimer's disease (AD) is a progressive neurodegenerative disease. This study was performed to determine the possible relationship between melatonin, which is known to play a role in the neuro-protective mechanism in AD, and fasciculation and elongation protein zeta 1 (FEZ1). Thirty male rats were included and separated into 3 groups (n = 10) as vehicle (artificial cerebrospinal fluid), streptozotocin (STZ) and STZ+melatonin (MLT). Two intracerebroventricular (icv) injections of 3 mg/kg STZ were made 48 hours apart. MLT injections were implemented for 14 days (ip; 10mg/kg/day). The Morris Water Maze (MWM) test was performed and rats were sacrificed to assess FEZ1 gene expression and protein levels from the hippocampus tissues and serum levels of noradrenaline (NA), dopamine and serotonin were determined from the blood samples. It was determined that the FEZ1/beta-actin protein ratio in the STZ group was significantly higher than that of the Vehicle group (p < 0.05) and in the MLT-administered group, the protein levels were decreased to the levels observed in the Vehicle group. Serum NA levels of STZ and STZ+MLT groups were found to be lower than those in the Vehicle group, while no difference was found regarding dopamine and serotonin levels. These findings show that reversal of increased FEZ1 levels in AD-induced rats with melatonin administration is the evidence of the effect of melatonin through FEZ1 in AD (Tab. 2, Fig. 5, Ref. 67).Öğe The role of miRNAs targeting K-ras and APC genes in colorectal cancer(Comenius Univ, 2020) Yilmaz, N.; Yilmaz, U.; Tanbek, K.; Arikan, S.; Aksakal, N.; Zeybek, U.; Ergen, A.OBJECTIVES: The occurrence of abnormal expression patterns in different types of cancer suggests that micro RNAs (miRNAs) may play an important role in tumorigenesis. The aim of this study was to examine the expression levels of miRNAs known to be associated with the regulation of the expression levels of the APC and K-ras, which are important in the development of colorectal cancer (CRC). METHODS: The expression levels of miR-27, miR-663, miR-217, miR-181d, APC and K-ras in the serum, tumor and adjacent tumor-free (healthy) tissues of the patients and serum of the healthy controls were investigated with qRT-PCR. RESULTS: Expression levels of miR-217, mR-181d, miR-663, miR-27 and K-ras were found to be higher in CRC tissues than in adjacent tumor-free tissues of the patients. In patient serum samples, miR-663 levels were statistically more elevated than in controls. In patient tumor tissues, miR-217, miR-181d and miR-27 expressions were found to be higher. CONCLUSIONS: Increased miR-181d and miR-217 expression levels are associated with increased K-ras expression in the tumor tissues, and the expression of K-ras, which takes part as an oncogene in the CRC development, might be regulated by these miRNAs (Tab. 4, Ref. 33). Text in PDF www.elis.sk
