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    Physical and chemical characterization of the femur during and after the body development period in male and female guinea pigs
    (Wiley, 2023) Yilmaz, Yuecehan; Aslan Kanmaz, Yesim; Baygeldi, Saime Betuel; Guezel, Baris Can; Karan, Meryem; Guezel, Fuat; Yilmaz, Sadik
    In this study, it was aimed to reveal the physical and chemical characterization of the bone structures during body development periods (prepubertal period, period between adolescence and adulthood) and after (young adult period and old adult period) in male and female guinea pigs. In this study, 40 guinea pigs (20 male, 20 female) were used. Morphometric measurements, X-ray fluorescence (XRF) analysis for mineral levels, Brunauer-Emmett-Teller (BET) analysis for surface area, and porosity analysis were applied to the bones. The male guinea pigs had greater values than females in the other three categories, with the exception of the second group, when the females have higher values in morphometric measurements. Ca levels rose up to the third group, as did P levels in the males, peaking in the third group and declining in the fourth. As with phosphorus, there was a progressive rise in females from the first to the fourth group. Fe, Zn, and Sr elements had the greatest values in both genders in the first group. In all four groups, the females had greater Zn levels than males. The highest Ca/P ratio was found in the third male group and the fourth female group. This study revealed that adolescence, adulthood, and gender are effective in the physical and chemical characterization of bone structure in guinea pigs.
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    The effects of SARS-CoV-2 vaccines on antinuclear autoantibody formation in individuals without prior COVID-19 infection
    (Elsevier Science Inc, 2025) Disli, Faruk; Yilmaz, Yuecehan; Yildiz, Sedat
    Background: Viral particles in SARS-CoV-2 vaccines have molecular motifs resembling self-antigens, potentially triggering autoantibody production. This study aimed to investigate the effects of mRNA vaccines (BioNTech), which contain a single viral particle, and inactivated whole viral particles (Sinovac) on antinuclear autoantibody (ANA) formation in individuals without prior COVID-19 infection. Material and Methods: The study was retrospective and included individuals who had not contracted SARS-CoV-2 (tested negative for antigen or antibody). The effects of the inactivated vaccine were assessed in individuals with samples before and after both doses (n = 36); the mRNA vaccine was evaluated in individuals unvaccinated and after two doses (n = 17); and the effects of both vaccines were assessed in individuals who received only the inactivated vaccine (n = 15), only the mRNA vaccine (n = 15), or both (n = 15). ANAs were determined using validated anti-dsDNA, anti-ENA, and anti-Hep-2 nucleus tests. Results: The inactivated vaccines cumulatively increased (p < 0.05) positivity for anti-dsDNA (from 13.9 to 36.1%) and anti-Hep-2 nuclear antibody (from 13.9 to 38.9%) but not anti-ENA antibodies (from 11.1 to 22.2%). The mRNA vaccine did not affect ANA formation compared to unvaccinated stages (p > 0.05). On the other hand, combination of both vaccine types increased the rate of positivity for the anti-dsDNA antibody (from 20.0 to 53.3%, p < 0.05). Conclusions: Small, yet valuable, sample size suggest that whole molecule vaccines may increase likelihood of ANA formation, probably due to exposure to increased number of assorted viral epitopes. Moreover, combination of both vaccines appears to increase anti-dsDNA antibodies and this deserves further investigation.