Yazar "Yilmaz I." seçeneğine göre listele
Listeleniyor 1 - 7 / 7
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Bioequivalence of the veterinary medicine(University of Ankara, 2008) Yilmaz I.In this review; short definition of bioequivalence, situations where bioequivalence studies require, the study types, experimental design and evaluation criteria and analysis of the results with studies conducted in veterinary medicine are summarized. Moreover, in the view of veterinary medicine marketing is important and it is believed that the most valuable quality control testing in our country's scientist realised and the results of study that have been used easily as an indicator, and these are presented and the legal arrangements should be made without delay once again were to be highlighted.Öğe Changes in tyrosine hydroxylase activity, adrenomedullin (ADM) and total RNA levels by treatment of organoselenium compounds in rat hypothalamus exposed to 7, 12-dimethylbenzanthracene (DMBA)(2010) Ozdemir I.; Talas Z.S.; Gok Y.; Ates B.; Yilmaz I.The effects of synthetic organoselenium compounds (Se I and Se II) on the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis as well as adrenomedullin (ADM) and total RNA levels were determined in the hypothalamus of adult rats exposed to DMBA (7,12-dimeuiylbenz[a] anthracene). DMBA, an organic environmental pollutant, is a polycyclic aromatic hydrocarbon that can induce a range of toxic effects and stress in rats. Selenium is an essential trace element, which interacts with antioxidants, and has anticancer and antihypertensive properties. TH is an aromatic amino acid hydroxylase whose activity is elevated in response to a range of stress inducers. TH activity is normally regulated by negative feedback in catecholamine biosynthesis. ADM is an abundantly present peptide in a broad range of normal tissues including adrenal medulla, lungs, kidneys and brain. Plasma ADM levels are elevated in a number of diseases including essential hyptertension and chronic renal failure. The antioxidant properties of ADM offer protection against organ damage induced by high blood pressure, ischemia and aging. DMBA treatment increased the TH activity and ADM level in the hypothalamus. These increases were found to be inhibited by Se I and Se II treatments. These studies demonstrate that synthetic organoselenium compounds can suppress DMBA-induced stress-related changes in the rat hypothalamus. Therefore, the antioxidant and antihypertensive effects of Se I and Se II may have important effects in the maintainance of homeostasis. © by PSP.Öğe Cytotoxic effects of cucurbitacin i and ecballium elaterium on breast cancer cells(Natural Product Incorporation, 2018) Yilmaz K.; Karakuş F.; Eyol E.; Tosun E.; Yilmaz I.; Ünüvar S.The objective of this study was to investigate the inhibitory effect of cucurbitacin I (CuI) and Ecballium elaterium L. (fruit juice and chloroform extract) on breast cancer cells (MCF-7 and MDA-MB-231). The CuI content of E. elaterium fruit juice and chloroform extract was quantified using high performance liquid chromatography. The cytotoxic effects of the fruit juice, chloroform extract and CuI were determined by MTT, wound healing and colony formation assays; all had an anti-proliferative activity on the breast cancer cells. Clarifying the mechanisms of cucurbitacins will enable the identification of new molecular targets for breast cancer therapy. © 2018 Natural Product Incorporation.Öğe Effect of Vitreoscilla hemoglobin on production of a chemotherapeutic enzyme, L-asparaginase, by Pseudomonas aeruginosa(2006) Geckil H.; Gencer S.; Ates B.; Ozer U.; Uckun M.; Yilmaz I.The production of L-asparaginase, an enzyme widely used in cancer chemotherapy, is mainly regulated by carbon catabolite repression and oxygen. This study was carried out to understand how different carbon sources and Vitreoscilla hemoglobin (VHb) affect the production of this enzyme in Pseudomonas aeruginosa and its VHb-expressing recombinant strain (PaJC). Both strains grown with various carbon sources showed a distinct profile of the enzyme activity. Compared to no carbohydrate supplemented medium, glucose caused a slight repression of L-asparaginase in P. aeruginosa, while it stimulated it in the PaJC strain. Glucose, regarded as one of the inhibitory sugars for the production L-asparaginase by other bacteria, was determined to be the favorite carbon source compared to lactose, glycerol and mannitol. Furthermore, contrary to common knowledge of oxygen repression of L-asparaginase in other bacteria, oxygen uptake provided by VHb was determined to even stimulate the L-asparaginase synthesis by P. aeruginosa. This study, for the first time, shows that in P. aeruginosa utilizing a recombinant oxygen uptake system, VHb, L-asparaginase synthesis is stimulated by glucose and other carbohydrate sources compared to the host strain. It is concluded that carbon catabolite and oxygen repression of L-asparaginase in fermentative bacteria is not the case for a respiratory non-fermentative bacterium like P. aeruginosa. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.Öğe The effects of dried apricot supplementation on daily food intake in rats(Turkish Pharmacists Association, 2013) Yilmaz I.; Do?an Z.; Soysal H.The aim of this study is to investigate the effects of sun dried organic apricot (SDOA) (Prunus armeniaca L.) supplementation on the daily food consumption of rats. In this study, 120 male and 120 female Sprague Daw ley rats were used. They were grouped as 24 rat per group of female and male rats. Group 1 (control)was fed up with standart rat chow, group 2; 1%, group 3; 2.5%, group 4; 5% and group 5 were fed up with 10% SDOA supplemented chow throughout 16 days. At the beginning of the study the body weight of the male rats was measured as 321±24.6 g (n=120), and the body weight of the female rats was 210±21.4 g (n=120). The daily avarage normal food intake of control group of male and female rats were determined as 24±1.9 g/rat/day and 16±1.1 g/rat/day respectively. Consequently, it can be confidently said that in the ratio of 2.5% ve 5% supplementation of SDOA food on the male rats, 10% suplementation on the female rats have a significant positive effect in their daily food consumption.Öğe The effects of synthetic organoselenium compounds on nitric oxide in DMBA - Induced rat liver(Triveni Enterprises, 2009) Talas Z.S.; Bayraktar N.; Ozdemir I.; Gok Y.; Yilmaz I.DMBA (7,12-dimethylbenz[a]anthracene) is known to generate DNA-reactive species during their metabolism, which may enhance oxidative stress in cells. Since selenium is known as a non-enzymic antioxidant, health problems induced by many environmental pollutants, have stimulated the evaluation of relative antioxidant potential of selenium and synthetic organoselenium compounds. Therefore, we aimed to evaluate chemopreventive potential of synthetic organoselenium compounds by monitoring level of liver nitric oxide. In this study, adult female Wistar rats were treated with DMBA and the novel organoselenium compounds (Se I) and (Se II) in the determined doses. DMBA-induced in rats, the effects of organoselenium compounds on nitric oxide levels in rat liver was studied. In this study, it has been observed a statistically significant increase in (Nitric Oxide) levels for the liver of rat exposed to DMBA (p<0.05). However with administration of Se I and Se II there was a statistically significant decrease in NO levels (p<0.05). The ability of the organoselenium compounds to prevent oxidative damage induced by DMBA in rat livers was rationalized. Protection against nitric oxide measured in Se I and Se II treated groups were provided by synthesized organoselenium compounds. Se I and Se II both provided chemoprevention against DMBA-induced oxidative stress in rat liver. © Triveni Enterprises.Öğe Modulation of DMBA-induced biochemical changes by organoselenium compounds in blood of rats(2007) Ozdemir I.; Selamoglu Z.; Ates B.; Gok Y.; Yilmaz I.The protective role of two synthetic organoselenium compounds 1-isopropyl-3-methylbenzimidazole-2-selenone (SeI) and 1, 3-di-p-methoxybenzylpyrimidine-2-selenone (SeII) was examined against the 7,12-dimethylbenz[a]anthracene (DMBA)-induced changes in biochemical parameters in blood of rats. Albino Winstar rats (150-200 g body wt) were treated with single dose of DMBA (50 mg/kg body wt) and organoselenium compounds (25 ?mol/kg) for 4 weeks at two days internal. Blood was taken from the anaesthetized rats ventricle from their hearts for biochemical analysis. Administration of DMBA resulted in elevation of urea, uric acid and creatinine levels as well as AST, ALT and LDH activities and decrease in levels of total proteins, albumin and globulin. SeI and SeII caused a significant (p<0.05) decrease in urea, uric acid and creatinine levels and alanine aminotransferase (ALT); aspartate aminotransferase; (AST) and lactate dehydrogenase (LDH) activities and significantly increased the levels of total protein and albumin (p<0.05). These organoselenium compounds are likely to be beneficial in human health.
