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Öğe Comparison of biochemical, antimicrobial and cytotoxic activities of different propolis samples from Malatya and Bilecik(Syscom 18 SRL, 2020) Keskin M.; Karlidag S.; Yilmaz O.; Tatlici E.; Karabulut E.; Apohan E.; Yesilada O.Propolis is a resinous natural mixtures collected and produced by honey bees. It is rich in essential oils and phenolic components so it has high levels of antioxidant, antimicrobial, anti-inflammatory and anti-tumoral activity. In this study the biochemical activity of propolis extracts were determined. The antimicrobial activity and cytotoxic activity of the extracts of the nine different propolis samples were invastigated. Their antimicrobial activities were tested by microdillution metod and define as minimum inhibitory concentration (MIC). Chemical composition of extracts was determined by using GC-MS equipment. Total phenolic content and antioxidant activity of the extracts was measured. Antimicrobial and cytotoxic activity of the extracts was carried out as well. All of the extracts showed antimicrobial activity on bacteria and yeasts used. Extracts had generally lower MIC values on yeasts. Therefore, yeasts were detected as more susceptible against the propolis extracts than the bacteria. Cytotoxic activity of extract were determined aganist A549 and Beas2B cell lines and IC50 values were calculated. Ma-Arapgir had the highest cytotoxic activity on A549 and Beas2B. They were determined as 6.72 and 26.44 mg/mL, respectively. It could be concluded that propolis extracts have antimicrobial and cytotoxic activity thus, propolis could be used in the treatment of cancer. © 2020 SYSCOM 18 S.R.L.. All rights reserved.Öğe Investigating inhibitory effects of punica granatum fruit extracts on lipid peroxidation in the fenton reagent environment(Chemical Publishing Co., 2012) Ozsahin A.D.; Kirecci O.A.; Yilmaz O.; Erden Y.; Bircan B.; Karaboga Z.In this study, it is aimed to find antioxidant activity of methanolic extract of Punica granatum fruit, by determining a,a-diphenyl-b- picrylhydrazyl (DPPH) radical scavenging property and also by determining the capacity to prevent the formation of lipid peroxidation which is found in in-vitro environment that soybean and corn oils are found. The capacity of preventing lipid peroxidation was analyzed in an in vitro environment that oil samples were existed by evaporating methanol phase of extracts. In the experiment, the groups were formed as control group e.g., Fenton reactive, Pomegranate extract + Fenton reactive. It was observed that the lipid peroxidation level formed on the oils had increased at a significant level when compared to Fenton reactive groups according to the control group. When the extract groups are compared (to each other) according to the Fenton reactive group, it was detected that lipid peroxidation level had significantly decreased (p > 0.0001). According to the scavenging activity of ?,?-diphenyl-?-picrylhydrazyl radical, it was determined that the pomegranate extracts were effective at their highest level at 250-500 ?L (p < 0.0001). It was concluded that Punica granatum effectively decreases the lipid peroxidation level, neutralizes the ?,?-diphenyl-?-picrylhydrazyl free radical and has a characteristic of conserving the fatty acid content.Öğe Radical scavenging activities of some Vitis vinifera varieties grown in malatya (Turkey) and their preventive effects on the formation lipid peroxidation in unsaturated fatty acids mediated(Chemical Publishing Co., 2010) Ozsahin A.D.; Yilmaz O.; Tuzcu M.; Kirecci O.A.; Guvenc M.This study examined the phytochemical characteristics of five samples of Vitis vinifera grown in the Malatya region of Turkey and investigated their impacts on human health by determining their antioxidant activities in vitro. The present research includes five native grape varieties (white: Tahanebi, Sam and Kureys; red: Köhnü; black: Banazi Karasi). Antioxidative activities of the grape extracts were determined with the following modifications. The free radical scavenging effect in extracts was assessed by the decolouration of a methanolic solution of DPPH. Lipid peroxidation level was found to be significantly high in the Fenton reagent (FR) containing group when compared to the control group (p < 0.0001). However, lipid peroxidation level decreased significantly in the groups to which grape extracts were added (p < 0.0001). According to DPPH results, all grape samples showed effective antioxidant activity in different concentrations and these activities were observed to change in parallel with the increase in flavonoid concentration. The results indicate that the grape fruit extracts decrease lipid peroxidation level in the Fenton reagent environment and have scavenging effect on the DPPH depending on grape varieties.Öğe The technical and financial effects of parenteral supplementation with selenium and vitamin E during late pregnancy and the early lactation period on the productivity of dairy cattle(Asian-Australasian Association of Animal Production Societies, 2015) Bayril T.; Yildiz A.S.; Akdemir F.; Yalcin C.; Köse M.; Yilmaz O.This study aimed to determine the effects of parenteral selenium (Se) and vitamin E supplementation on economic impact, milk yield, and some reproductive parameters in high-yield dairy cows in the dry period and in those at the beginning of lactation. At the beginning of the dry period, cows (n = 323) were randomly divided into three groups as follows: Treatment 1(T1), Treatment 2(T2), and Control (C). Cows in group T1 received this preparation 21 days before calving and on calving day, and cows in group T2 received it only on calving day. The cows in the control group did not receive this preparation. Supplementation with Se increased Se serum levels of cows treated at calving day (p<0.05). Differences in milk yield at all weeks and the electrical conductivity values at the 8th and 12th weeks were significant (p<0.05). Supplementation with Se and Vitamin E decreased the incidence of metritis, the number of services per conception and the service period, but had no effects on the incidence of retained fetal membrane. A partial budgeting analysis indicated that Se supplementation was economically profitable; cows in group T1 averaged 240.6$ per cow, those in group T2 averaged 224.6$ per cow. Supplementation with Se and Vitamin E has been found to increase serum Se levels, milk yield, and has positive effects on udder health by decreasing milk conductivity values and incidence of sub-clinical mastitis. Copyright © 2015 by Asian-Australasian Journal of Animal Sciences.
