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  • Küçük Resim
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    Clinicopathologic features of operated gastric cancer patients, single center nine years experience
    (2020) Yol, Sinan; Uzun, Orhan; Senger, Aziz Serkan; Dincer, Mursit; Polat, Erdal; Duman, Mustafa; Deger, Kamuran Cumhur; Cigiltepe, Huseyin; Gundes, Ebubekir; Cetin, Durmus Ali; Aday, Ulas
    Aim: Gastric cancer is one of most common malignancies in the world. In developed countries including Europe and United States, despite the advanced technology, advanced stages of gastric cancer are still common with a poor survival. In this study, we aimed to describe clinicopathological characteristics and outcomes of gastric cancer in patients who were operated in our clinic.Material and Methods: We respectively evaluated a total of 200 patients who underwent gastrectomy, D2 lymph node dissection due to gastric cancer between November 2006 and December 2015. Data including clinicopathologic features, postoperative complications, overall survival and prognostic factors affecting prognosis were analyzed and statistical analysis was performed. Data including clinicopathologic features, postoperative complications, overal survival and prognostic factors affecting prognosis were analyzed and statistical analysis was performed.Results: Of the patients, 134 (67%) were males and 66 (33%) were females. The mean age was 61.36±11.92 (28-91) years. Tumor localization was frequently low (57%). The most common postoperative complication, regardless of the type of gastrectomy, was the surgical site infection. The major of the patients had Stage 3 disease. The median overall survival was 24.9 (0.07-116.3) months and overall survival was 43.7%.Conclusion: Except for early stage, the chance of curative treatment is low in gastric cancer. Early diagnosis and treatment can yield improved outcomes for this patient population. Therefore, it is important to develop national programs for early diagnosis and to develop experienced endoscopists
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    Comparison of the microvessel density of gastric regions in normal and sleeve gastrectomized rats
    (2018) Orman, Suleyman; Yol, Sinan; Uzun, Huseyin; Ceyran, Ayse Bahar
    Aim: Background: The aim of this study is to compare the microvessel densities of different normal gastric regions and to determine the effects of sleeve gastrectomy on the microvessel density of tissues alongside the remnant stomach. Material and Methods: Twenty male Wistar albino rats were divided into two groups. Rats in the control group were immediately sleeve gastrectomized under anesthesia and a wedge resection of the esophagogastric junction (EGJ), the fundus, corpus and antral gastric regions was performed, before sacrifice. Meanwhile, rats in the experiment group also underwent sleeve gastrectomy but were not sacrificed until the 5th postoperative day. At this point, gastric tissues alongside the sleeve gastrectomy area were then wedge-resected. The microvessel densities of these two groups were evaluated and compared. Results: When comparing distinctive gastric regions within the control group, the microvessel density of the esophagogastric junction was found to be less than in the corpus or fundus (20.04±4.45; 36.28±9.98, 39.4±9.57; p <0.01). When comparing the control and experiment groups, No significant difference in the microvessel density of the esophagogastric junction was found (20.04 ± 4.45, 24.63 ± 8.91, p> 0.05). The sleeve gastrectomy also had no significant effect on the microvessel densities at the esophagogastric junction or corpus (24.63±8.91, 22.24±7,63; p> 0.05). Conclusion: The esophagogastric junction has a lower microvessel density than the corpus in a normal stomach. Sleeve gastrectomy has no adverse effect on the microvessel density of the esophagogastric junction.
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    Effects of carbon dioxide pneumoperitoneum on hepatic function in obstructive jaundice: an experimental study in a rat model
    (Springer, 2010) Bostanci, Erdal Birol; Yol, Sinan; Teke, Zafer; Kayaalp, Cuneyt; Sakaogullari, Zisan; Turkcu, Ummuhani Ozel; Bilgihan, Ayse
    The physiology of the patient during laparoscopy differs from that of open surgery. Both pneumoperitoneum and obstructive jaundice impair the hepatic function, but the combined insult has not been previously examined. In this study, we aimed to investigate the effects of carbon dioxide (CO2) pneumoperitoneum on hepatic function in a rat model of obstructive jaundice. Forty-four male Sprague-Dawley rats were divided into four groups: group 1 (n = 10), sham-operated group; group 2 (n = 12), obstructive jaundice group; group 3 (n = 10), CO2 pneumoperitoneum group; and group 4 (n = 12), obstructive jaundice and CO2 pneumoperitoneum group. Common bile duct was ligated and divided in the obstructive jaundice groups. After 6 days, a 12-mmHg pneumoperitoneum was induced, maintained for 60 min, and released for 120 min. Blood samples were drawn for the measurement of white blood cell and platelet counts, serum liver enzymes (aspartate aminotransferase [AST], alanine aminotransferase [ALT], total bilirubin). Tissue samples were obtained for analyses of malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) levels. We evaluated the degree of liver injury on a grading scale from 0 to 4, histopathologically. Pneumoperitoneum after biliary obstruction resulted in an increase in AST and ALT levels and a decrease in white blood cell and platelet counts. However, changes in liver tissue MDA, GSH, and SOD levels did not correlate with the changes in AST and ALT levels and white blood cell and platelet counts. After sham operation with pneumoperitoneum, the GSH levels in liver homogenate were significantly decreased in the group 3 when compared to the group 2. On the other hand, obstructive jaundice itself caused significant reduction in the SOD activity of liver homogenate in comparison to the group 3. Histopathologically, sinusoidal congestion and vacuolization were more severe in the group 3. Alterations in hepatic function occur in pneumoperitoneum applied jaundiced subjects. However, there were no statistically significant differences between the groups 2 and 4 with regard to white blood cell and platelet counts, serum liver enzymes including AST, ALT, and total bilirubin values, MDA and GSH levels and SOD activity of liver homogenate, and histologic damage. These results indicate that there is no additional risk on liver function associated with pneumoperitoneum performed in obstructive jaundice.