Yazar "Yoloğlu, Saim" seçeneğine göre listele
Listeleniyor 1 - 20 / 104
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe 1980-2000 Yılları Arasında Malatya ve Türkiye’de Beklenen Yaşam Süreleri Değişiminin İncelenmesi(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2004) Otlu, Harika Gözükara; Yoloğlu, SaimBu çalışma, Malatya ve Türkiye il ve ilçe merkezleri için yaşam tabloları oluşturarak, önemli bir gelişmişlik ve sağlık göstergesi olan beklenen yaşam sürelerinin hesaplanmasını amaçlamıştır. Gereç ve Yöntem: Çalışmada hazırlanan yaşam tabloları, Malatya ve Türkiye il ve ilçe merkezleri kısaltılmış kesitsel yaşam tablolarıdır. Bulgular: Malatya il ve ilçe merkezleri için 1980 yılında doğuşta beklenen yaşam süresi kadınlarda 73.80 yıl ve erkeklerde 69.58 yıl iken, 2000 yılında sırasıyla; 76.81 ve 73.38 yıl olarak bulunmuştur. Doğuşta beklenen yaşam süresi, Malatya ilinde her iki cins için 20 yıllık zaman zarfında yaklaşık 3.5 yıllık bir artış göstermiştir. Türkiye il ve ilçe merkezleri için doğuşta beklenen yaşam süresi 1980 yılında kadınlarda 65.91 yıl, erkeklerde 60.72 yıl ve 2000 yılında sırasıyla; 77.58 ve 72.27 yıl olarak bulunmuştur. Türkiye için doğuşta beklenen yaşam süresi, 1980-2000 yılları arası her iki cins için yaklaşık 12 yıllık bir artış göstermiştir. Sonuç: Türkiye’de bebek ve çocuk ölüm hızlarının gelişmiş ülkelere nazaran yüksek olması, beklenen yaşam sürelerinin gelişmiş ülkelerinkinden düşük olmasına neden olmuştur.Öğe Abnormal foetal heart rate pattern and their relationship to amniotic fluid erythropoietin levels(2005) Çelik, Önder; Hasçalık, Şeyma; Güven, Alanur; Turhan, Fahri; Yoloğlu, SaimAbstract: OBJECTİVE: The aim of the study was to evaluate the relationship between abnormal foetal heart rate pattern and erythropoietin concentrations in amniotic fluid, umbilical cord, maternal plasma and 1 and 5 minutes Apgar scores. STUDY DESİGN: Twenty-one patients with abnormal FHR patterns in the non-stress test were included to this study. All patients underwent caesarean section. Amniotic fluid, maternal and umbilical cord samples were obtained for erythropoietin levels. We measured amniotic fluid erythropoietin, maternal serum erythropoietin and umbilical cord blood erythropoietin by radio-immunoassay. Apgar scores at 1 and 5 minutes were recorded. RESULTS: Umbilical cord, amniotic fluid and maternal serum erythropoietin levels were found 62.7±67.3 mU/ml, 26.8±22.1 mU/ml and 36.1±38.9 mU/ml respectively. UA-EPO levels were higher than AF-EPO (p=.016). MS-EPO and UA-EPO levels were similar (p=.070). Similarly, MS-EPO and AF-EPO levels were not different (p=.523). Four of the 21 infants had low Apgar scores at 1 and 5 minutes. Three of four patients MS-EPO, AF-EPO and UA-EPO levels were normal. In only one of four patients UA-EPO level was found elevated but AF-EPO and MS-EPO levels were normal. Seventeen infants had normal Apgar scores despite an abnormal foetal heart rate pattern. CONCLUSİON: We conclude that abnormal foetal heart rate pattern may signal imminent foetal risk but do not confirm foetal hypoxia. We did not find any correlation between abnormal foetal heart rate pattern, AF-EPO, UA-EPO and MS-EPO levels, and Apgar scores of 1 and 5 minutes.Öğe Aflatoksin Bı in tavşan eritrosit, karaciğer, böbrek arginaz aktiviteleri ile serum ALP, AST, ALT düzeylerine etkisi(İnönü Üniversitesi Tıp Fakültesi Dergisi, 1994) Temel, İsmail; İlhan, Necip; Emre, Hanifi; Çığlı, Ahmet; Yoloğlu, Saim; Karakaş, SacideOtuz tavşan A.B.C ve kontrol olmak üzere dört gruba ayrıldı. A,li,(' gruplarına üç ay süreyle farklı dozlarda aflatoksin B/ (AFBt ) verildi. Diğer taraftan kontrol grubu normal besinlerle beslendi. Serum ALP.AST.ALTdüzeyleri AFBj uygulamasından fince ve sonra tesj>it edildi. Eritrosit, karaciğer, ve böbrek arginaz aktiviteleri yalnızca AFBt uygulamasından sonra ölçüldü. AST ve ALT nin ilk ve son değerleri arasındaki fark istatiksel olarak önemliydi fakat ALP düzeyleri önemsizdi. AST ve ALT düzeylerindeki artış doğrudan AFBt dozları He ¡İşkiliydi. A,B ve C gruplarındaki eritrosit, karaciğer ve böbrek arginaz aktiviteleri kontrol grubu ile kıyaslandı. Yalnızca karaciğer arginaz düzeyi istatiksel olarak önemli bulundu. Sonuç olarak AFB/ in çok küçük dozlarının bile etkisini özellikle karaciğer üzerinde gösterdiğini ve hepatosellüler hasara neden olduğu kanısına vardık. AST ve ALİ' düzeylerindeki artışlar karaciğer arginaz aktivitesiy/e paralelık arzetmekteydi.Öğe Aflatoksin Bı in tavşanlarda bazı kan parametreleri üzerindeki etkisi(İnönü Üniversitesi Tıp Fakültesi Dergisi, 1994) Emre, M.Hanifi; Karakaş, Sacide; Otlu, Ali; Temel, İsmail; Yoloğlu, SaimÇalışmada, Yeni Zelanda ırkı (Oryctolagus cuniculus huxleyi) 30 erkek tavşan kullanıldı. Tavşanlar gruplandırıldı ve deneklerin A grubuna 0.005, Bgrubuna 0.0075 ve Cgrubuna 0.010 mgr/kg/gün aflatoksin Bj verildi. I 'eriler çift yönlü varyans ve korelasyon analizine tabi tutuldu. Lökosit, eritrosit sayıları, hematokrit değeri ve tek bir eritrositin ortalama hemoglobin değeri (MCH) deneme gruplan, ölçümler arası ve etkileşim bakımından istatistiksel olarak önemli farklar gösterdi. Hemoglobin değeri ve trombositlerin sayısı sadece ölçümler arası bakımından istatistiksel olarak önemli farklılıklar gösterirken tek bir eritrositin ortalama hacim (MCI') değerleri deneme grupları arasındaki değer yönünden farklılık gösterdi. Bu farklılıklara karşın aflatoksin B, verilen bütün gruplarda zaman içerisinde trombosit sayısı ve hematokrit değerinde negatif lökosit sayısı, hemoglobin değeri ve tek bir eritrositin ortalama hemoglobin değerinde (MCH) ise başlangıca göre pozitif bir ilişki saptandı. Eritrosit sayısı, tek bir eritrositin ortalama hacmi (MCI) ve tek bir eritrositin ortalama hemoglobin konsantrasyonunda (MCHC) zaman içerisinde bazı gruplarda pozitif, bazı gruplarda negatif bir ilişki görüldü. I 'eriler literatür ile karşılaştırıldı ve tartışıldı.Öğe Aflatoksin Bı in tavşanlarda total vücut ağırlığı ve çeşitli organ ağırlıkları üzerine etkileri(İnönü Üniversitesi Tıp Fakültesi Dergisi, 1994) Emre, M.Hanifi; Otlu, Ali; Karakaş, Sacide; Yoloğlu, Saim; Temel, İsmailWe used 30 male rabbits belong to NewZelandrabbit strain (Oryctolagus cuniculus huxleyi) in this study. The rabbits were groupped and were given 0.005, 0.0075 and 0.010gr/kg/day respectively to A , B, Cgroups. It were not found istatistically diffrences between groups' weight of total body, right suprarenal gland, left and right kidney, heart, stomach, and salivary glands. On the other hand we have determined istatistically differences between groups-' weight of left suprarenal gland and lung. Data were compared and discussed with literature.Öğe Akşemseddin İşitme Engelliler İlköğretim Okulu öğrencilerinde bağırsak parazitleri ve baş biti görülme sıklığı(2007) Atambay, Metin; Karaman, Ömer; Karaman, Ülkü; Aycan, Özlem; Yoloğlu, Saim; Daldal, NilgünÖz: Parazit hastalıkları, büyüme ve gelişmenin en önemli dönemlerinde olan çocukları etkilemektedir. Çocuklarda malnutrisyon, malabsorbsiyon, zihinsel ve sosyal uyum bozukluğu gibi önemli rahatsızlıklara neden olabilmektedir. Ülkemizde de bağırsak parazitleri önemli bir sağlık sorunu olup, çocukların toplu yaşadığı kreş, anaokulu ve diğer okullarda daha sık görülmektedir. Araştırmada işitme engelliler ilköğretim okulu öğrencilerinde paraziter etkenlerin yaygınlığının belirlenmesi ve tedavisi amaçlanmıştır. İşitme engelli öğrencilerden 2003-2004 öğretim yılında 117 dışkı ve selofanlı lam yöntemiyle perianal bölge materyali alınarak incelenmiş, ayrıca öğrencilerde baş biti erişkini ve yumurtaları aranmıştır. Çalışmada 53 (%45,3) bağırsak paraziti ve 6 (%5,1) baş biti gözlenmiştir. Hastaların tedavileri yapılmış ve korunma yolları hakkında bilgi verilmiştir. Altı ay sonra tekrar aynı öğrenciler kontrol edilmiş 24 (%20,5) bağırsak paraziti ve 2 (%1,7) baş biti gözlenmiştir. Sonuç olarak paraziter hastalıklarda anlamlı bir düşüş gözlenmiştir (bağımlı örneklerde ki-kare testi P<0.05). Bu nedenle okullarda bağırsak paraziti ve baş biti açısından sağlık taramalarının yapılması ve tedavi ile eğitime önem verilmesi gerektiği kanısına varılmıştır.Öğe Alerjik deri testi ile ev tozu akarı arasındaki ilişki(2006) Atambay, Metin; Aycan, Özlem; Yoloğlu, Saim; Karaman, Ülkü; Daldal, NilgünÖz: 1960 yılından beri ev tozu akarlarının allerji ile ilişkileri ve bunların solunum yolu ile ilgili hastalıklara neden olduğu bilinmektedir. Ev tozu akarları çok çeşitli olup tıbbi önemi ve morfolojik özellikleri itibarıyla en iyi bilinenleri Dermatophagoides pteronyssinus (Trouessart, 1897) ve Dermatophagoides farinae (Hughes, 1961)'dir. Allerjik hastalıklarda akarların rolünün belirlenmesi için deri testleri kullanılmaktadır. Bu testlerde, D. pteronyssinus ve D. farinae'ye ait antijenler kullanılmaktadır. Hastaların deri testi sonuçlarının ev tozlarındaki akarların varlığıyla uyumlu olup olmadığının belirlenmesi amacıyla allerjik hastalık tanısı almış (allerjik rinit ve allerjik astım tanısı ) ve deri testi uygulanmış 49 hastanın evinden ev tozu alınarak tozda akar varlığı araştırılmış ve 23 (%46,3) evde ev tozu akarları saptanmıştır. Deri testi pozitif olan 30 hastanın 15 (%50)'inin, deri testi negatif olan 19 hastanın ise 8 (%42)'inin evlerinde akar saptanmıştır. Deri testi negatif ve pozitif olanlar arasında ev tozunda akar varlığı açısından anlamlı bir fark saptanamamıştır. (P›0,005). Sonuç olarak allerjik yakınmaları olan kişilerin deri desti negatif olsa da evlerinde akar aranması gerektiği düşünülmüştür.Öğe Alterations of Thyroid Functions in Obesity: Is There any Impact of Co-Existence of Type 2 Diabetes Mellitus?(2018) Topaloğlu, Ömercan; Sümer, Fatih; Çetin, Sedat; Yoloğlu, Saim; Kayaalp, Cüneyt; İbrahim ŞahinAbstract: Aim: Little is known about the effect of coexistent type 2 diabetes mellitus (DM) on thyroid functions in obesity. We aimed to evaluate the thyroid function in the both diabetic and nondiabetic obese patients. Materials and Methods: 145 obese patients admitted to our department, between June 2014 and May 2016, were included in the study. The patients with known thyroid dysfunction were excluded from the study. The patients were grouped according to their BMI (body mass index), co-existence of type 2 DM, and TSH (thyroid stimulating hormone). Data were collected retrospectively and analyzed. Results: No difference was observed between diabetic and nondiabetic groups for the mean age, body weight, fT3 (free T3), fT4 (free T4), BMI, TSH. Primary hypothyroidism, subclinical hypothyroidism and hyperthyroidism were determined in 1.4, 0.7 and 2.8 % of the patients, respectively; no difference was found between diabetic and nondiabetic groups (p=0.588). There was no significant correlation between BMI and TSH (r=0.030, p=0.717).Distribution of patients in different TSH groups between diabetic and nondiabetic groups were similar (p=0.533). There were positive correlations between BMI and, fT4 or fT3 (r=0.274, p=0.001; r=0.280, p=0.002; respectively). Although 1.4% of all patients had isolated elevation of fT4, there was no difference between groups (p=0.178). 24.6% of diabetic, 28.4% of nondiabetic and 26.6% of all patients had isolated elevation of fT3; however, no difference was found (p=0.634). Conclusions: Our study suggested that obesity could be associated with elevated fT4 and fT3. Elevation of fT3 and fT4 with increasing BMI may be as response to increased metabolic rate. We found no difference between diabetic and nondiabetic groups concerning to fT4 and fT3 elevation. As a result, co–existence of type 2 DM seems to have no effect on thyroid functions.Öğe Assesment of normal ECG percentiles and cardiac rhythm problems through 12-lead ECG screening in school-age children(2022) Yılmaz, Ercan; Elkıran, Özlem; İnce, Damla; Yılmaz, Zeynep Yamancan; Yoloğlu, Saim; Karakurt, CemşitAim: Electrocardiography (ECG) is an important non-invasive examination tool used for the diagnosis of cardiovascular diseases and rhythm problems for nearly hundred years. Although, many studies have been conducted showing the significant effect of age and gender on electrocardiographic traces, the data on normal reference values of pediatric ECG and the relationship between abnormal ECG recordings and heart disease are insufficient in the current literature. The aim of this study was to evaluate the standard percentile values of ECG measurement and the prevalence of cardiac disorders in school children aged 6-18 in our region. Materials and Methods: 2154 students who were randomly selected from eight elementary, secondary and high schools in Malatya city center were included in the study and informed consent form was taken from their families. Using MAC 2000 (GE Healthcare, Milwaukee, USA) device capable of taking digital ECG record, ECG records with standard 12 derivations were taken for all participating children. ECG records of all children were examined by the same pediatric cardiologists. Using 24 hour Holter ECG and echocardiography, advanced evaluation was performed for the children with problems detected in ECG records. Results: Pathology was detected in the ECG of 110 out of a total of 2154 children whose ECG records were examined. Average age of 2044 children without detected conduction and rhythm disorder was 11.4±2.8 and 56.8% (n=1149) were female. These eleven parameters were compared to the other studies in literature. Mean QTc interval was detected below 440 milliseconds in all age groups (6-9, 9-13, 13-18). Mean heart rate per minute was found higher in all age groups in our study compared to other studies. Thus mean QTc interval was found lower than the other studies although QT distance was similar. Conclusion: Data of this study is important for the detection of normal ECG percentiles and the prevalence of rhythm problems in children and would guide other future studies on this subject.Öğe Assessment of anxiety and depression levels of pregnant women with hyperemesis gravidarum in a case-control study(Journal of the Turkish-German Gynecological Association, 2012) Şimşek, Yavuz; Çelik, Önder; Yılmaz, Ercan; Karaer, Abdullah; Yıldırım, Engin; Yoloğlu, SaimÖz: Amaç: Bu yazıda Beck anksiyete ve depresyon skorlama sistemi kullanılarak hiperemezisli gebelerde anksiyete ve depresyon düzeylerinin araştırılması amaçlandı. Gereç ve Yöntemler: Çalışma için 1. trimesterdeki 86 gebeyi içeren bir olgu-kontrol çalışması yapıldı. Hiperemezis gravidarumlu 41 hasta ve sağlıklı kontrol grubu olarak 45 gebe dahil edildi. Gruplar yaş, parite ve vücut kitle indeksi değerleri açısından eşleştirildi. Tüm hastalardan serum TSH ve hCG düzeylerini de içeren bazal laboratuvar tetkikleri istendi. Bulgular: Gruplar arasında serum potasyum düzeyinin hiperemezisli olgularda anlamlı olarak düşük olması (p=0.039) dışında demografik, obstetrik ve laboratuvar değerleri açısından farklılık yoktu. Hiperemezisli hastaların depresyon ve anksiyete skorları kontrol grubuna göre anlamlı olarak daha yüksekti (Sırasıyla p=0.0001 ve p=0.049). Sonuç: Artmış anksiyete ve depresyon düzeyleri hiperemezis gravidarumun patogenezinde rol oynayabilir. Bu hastaların takip ve tedavilerinde ekstra psikolojik destek gerekebilir. (J Turkish-German Gynecol Assoc 2012; 13: 32-6)Öğe The association between retinopathy, hypertension and diabetes duration in type 2 diabetics: 6-years of experience(İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 2000) Şavlı, Haluk; Sevinç, Alper; Doğanay, Selim; Er, Hamdi; Yoloğlu, SaimÖz: Amaç: Artmış ateroskleroz ile birlikte hem mikrosirkülasyonda, hem de büyük damarlardaki vasküler komplikasyonlar diyabet morbidite ve mortalitesine neden olmaktadır. Körlüğe neden olabilen diyabetik retinopati, mikroanjiyopatinin de klinik bir göstergesidir. Materyal ve Metod: Çalışmamızda, Turgut Özal Tıp Merkezi Diyabet Kliniğinde, Haziran 1994 ile Şubat 2000 tarihleri arasında takip edilen, ortalama yaşları 53.50 ± 11.02 yıl olan 647 diyabetik hasta (274 erkek ve 373 bayan) değerlendirildi. Ortalama hastalık süreleri 7.90 ± 6.27 yıl idi. Hastalar, retinopati varlığına göre gruplandırıldı. Bulgular: Retinopati saptanan 181 hastanın (%27.97) (79 erkek ve 102 bayan) ortalama yaşları 57.63 ± 10.18 yıl ve ortalama diyabet süreleri 12.98 ± 6.41 yıl idi. Retinopati saptanmayan 466 hastanın (195 erkek ve 271 bayan) ortalama yaşları 51.90 ± 10.93 yıl ve ortalama hastalık süreleri 5.93 ± 4.98 yıl idi. Hipertansiyon, retinopati saptanmayan hastaların 210'unda (%45,06) ve retinopati saptanan hastaların 130'unda (%71.82) tesbit edildi. Retinopati sınıflaması yapıldığında, hastaların 93'ünde (%51,4) background retinopati, 46'sında preproliferatif retinopati (%25,4) ve 42'sinde (%23,2) proliferatif retinopati saptandı. Retinopati, diyabet süresi ile karşılaştırıldığında, background retinopati özellikle hastalık süresi 6-10 yıl arası olan hastalarda en fazla görülürken, preproliferatif retinopati 11-15 yıl ve proliferatif retinopati >15 yıldan fazla hastalık süresi olan gruplarda en fazla görüldü. Aynı hasta gruplarında hipertansiyon araştırıldığında, grup I'de (diyabet süresi 0-5 yıl olan hastalar) %52,4, grup 2'de (6-10 yıl) %75,4, grup 3'de (11-15 yıl) %64 ve grup 4'de (>15 yıl) %85,3 olarak bulundu. Sonuç: Diyabetik retinopatili hastalarda, hipertansiyon varlığı araştırılmalı ve saptandığında yoğun bir şekilde tedavi edilmelidir. Normotansif, hipertansif ve yoğun tedavi edilen hipertansif gruplarda, diyabetik retinopati sıklığı ve evrelendirilmesi çalışmaları yapılmalıdır. Başlık (İngilizce): Tip 2 diyabetli hastalarda retinopati, hipertansiyon ve hastalık süresi arasındaki ilişki: 6 yıllık deneyim Öz (İngilizce): Background: Morbidity and mortality in diabetes are caused mainly by its vascular complications, both in the microcirculation and in the large vessels with accelerated atherosclerosis. Diabetic retinopathy is the clinical hallmark of microangiopathy which may lead to blindness. Materials and method: This study was designed in type 2 diabetic patients who were on regular control and treatment in the diabetes clinic of Turgut Ozal Medical Center between June 1994 and February 2000. Six hundred and forty-seven type 2 diabetic patients (274 males and 373 females), aged 53.50 ± 11.02 years were evaluated. The mean diabetes duration was 7.90 ± 6.27 years. Patients were categorized according to the presence of retinopathy. Results: Retinopathy was encountered in 181 patients (27.97%) (79 males and 102 females), aged 57.63 ± 10.18 years. Their mean diabetes duration were 12.98 ± 6.41 years. Four hundred and sixty-six patients (195 males and 271 females), aged 51.90 ± 10.93 years formed the non-retinopathy group. The mean diabetes duration were 5.93 ± 4.98 years. Hypertension was present in 210 of patients (45.06%) without retinopathy and in 130 patients (71.82%) with retinopathy. In terms of grading of retinopathy, background retinopathy was encountered in 93 (51.4%) patients, preproliferative retinopathy was encountered in 46 (25.4%) patients, and proliferative retinopathy was encountered in 42 (23.2%) patients. When retinopathy was compared with diabetes duration, background retinopathy was highly encountered in patients with a duration of 6-10 years, preproliferative retinopathy was seen the most in 11-15 years, and proliferative retinopathy was found to be higher in >15 years. When presence of hypertension was investigated in these patients, we found out that 52.4% of patients in group 1 (patients with diabetes duration of 0-5 years), 75.4% of patients in group 2 (6-10 years), 64% of patients in group 3 (11-15 years), and 85.3% of patients in group 4 (>15 years) were hypertensive. Conclusion: The presence of hypertension should be investigated in patients with diabetic retinopathy and if present, should be treated aggressively. We need further studies in diabetic patients to consider the frequency and stage of retinopathy in normotensive, hypertensive, and aggresively treated hypertensive groups.Öğe Association of cardiac changes with serum adiponectin and resistin levels in obese and overweight children(J Cardiovasc Med 2013, 14:228–234., 2013) Akıncı, Ayşehan; Karakurt, Cemşit; Gürbüz, Sibel; Elkıran, Özlem; Nalbantoğlu, Özlem; Koçak, Gülemdar; Güldür, Tayfun; Yoloğlu, SaimObjectives To investigate serum adiponectin and resistin levels in childhood obesity and their relationship with cardiac changes and insulin resistance. Methods Seventy-one obese and 24 overweight children and 40 healthy children and adolescents were selected for the study. Height and weight measurements, BMI values and BMI SD score values were obtained for each individual. After blood pressure measurement, left ventricular wall thickness, left ventricular mass, stroke volume, cardiac output, systolic and diastolic functions of the left ventricle were measured using an M-mode, two dimensional colorcoded echocardiography device. Blood samples of the individuals were obtained for fasting blood sugar, total blood cholesterol, triglyceride, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein cholesterol, highdensity lipoprotein cholesterol, insulin, C-peptide, adiponectin and resistin values. Results Cholesterol and LDL values, homeostasis model assessment of insulin resistance, fasting insulin and fasting C-peptide values of the obese and overweight groups were higher (P< 0.01). Adiponectin level (P< 0.001) and resistin level (P< 0.05) of the obese and overweight groups were lower than those of the control group (P< 0.05). Echocardiographic evaluation showed diastolic dysfunction in addition to increased left ventricular wall thickness and left ventricle mass values in the obese and overweight children. We also detected a significant positive correlation among left ventricular mass, interventricular septum systolic diameter and resistin in obese children. Among the factors, resistin level was determined as an independent predictor of left ventricular mass in obese children. Conclusion In this study, even in asymptomatic obese and overweight children, cardiac structural and functional changes, such as increased left ventricular mass and diastolic dysfunction, were demonstrated. Although decreased adiponectin level was not related to cardiac changes, it was shown that decreased serum resistin levels in the obese cases lead to left ventricle hypertrophy.Öğe Association of cardiac changes with serum adiponectin and resistin levels in obese and overweight children(Journal of Cardiovascular Medicine, 2013) Akıncı, Ayşehan; Karakurt, Cemsit; Gürbüz, Sibel; Elkıran, Özlem; Nalbantoğlu, Özlem; Kocak, Gulendam; Güldür, Tayfun; Yoloğlu, SaimObjectives To investigate serum adiponectin and resistin levels in childhood obesity and their relationship with cardiac changes and insulin resistance. Methods Seventy-one obese and 24 overweight children and 40 healthy children and adolescents were selected for the study. Height and weight measurements, BMI values and BMI SD score values were obtained for each individual. After blood pressure measurement, left ventricular wall thickness, left ventricular mass, stroke volume, cardiac output, systolic and diastolic functions of the left ventricle were measured using an M-mode, two dimensional colorcoded echocardiography device. Blood samples of the individuals were obtained for fasting blood sugar, total blood cholesterol, triglyceride, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein cholesterol, highdensity lipoprotein cholesterol, insulin, C-peptide, adiponectin and resistin values. Results Cholesterol and LDL values, homeostasis model assessment of insulin resistance, fasting insulin and fasting C-peptide values of the obese and overweight groups were higher (P<0.01). Adiponectin level (P<0.001) and resistin level (P<0.05) of the obese and overweight groups were lower than those of the control group (P<0.05). Echocardiographic evaluation showed diastolic dysfunction in addition to increased left ventricular wall thickness and left ventricle mass values in the obese and overweight children. We also detected a significant positive correlation among left ventricular mass, interventricular septum systolic diameter and resistin in obese children. Among the factors, resistin level was determined as an independent predictor of left ventricular mass in obese children. Conclusion In this study, even in asymptomatic obese and overweight children, cardiac structural and functional changes, such as increased left ventricular mass and diastolic dysfunction, were demonstrated. Although decreased adiponectin level was not related to cardiac changes, it was shown that decreased serum resistin levels in the obese cases lead to left ventricle hypertrophy.Öğe Atrial fibrillation after coronary artery bypass grafting in elderly patients ıncidence and risk factor analysis(The Thoracic and Cardiovascular Surgeon, 2007) Nisanoğlu, Vedat; Erdil, Nevzat; Aldemir, Mustafa; Özgür, Bülent; Cihan, H. Berat; Yoloğlu, Saim; Battaloğlu, BektaşObjective: New-onset atrial fibrillation (AF) is the most frequent arrhythmic complication after coronary artery bypass grafting (CABG). Elderly patients who undergo this operation may have a different risk profile from the general population. The aim of this study was to identify risk factors for post-CABG AF in the elderly population. Methods: Between September 2001 and December 2005, 426 elderly patients (age ≥ 65 years) underwent CABG at our center. Ninety-one developed post-CABG AF (AF group), and the other 335 (no-AF group) did not develop this complication. Multivariate analysis (odds ratio, ± 95 % CI, p value) was used to identify independent clinical predictors of post-CABG AF. Results: The incidence of post-CABG AF in elderly patients during the study period was 21.4 %. Multivariate analysis identified age (OR 1.07, p < 0.009), age ≥ 75 years (OR 1.77, p < 0.042), preoperative renal insufficiency (OR 5.09, p < 0.035), EuroSCORE (OR 1.18, p < 0.038), and cross-clamping time (OR 1.02, p < 0.012) as predictors of AF occurrence. The AF group had a significantly longer mean intensive care unit (ICU) stay (3.8 ± 4.7 vs. 2.5 ± 1.3 days for AF vs. no-AF; p = 0.0001), and a significantly higher proportion of patients with prolonged (≥ 6 days) ICU stays (8.8 % vs. 3.2 %, respectively; p = 0.033). Hospital mortality was 3.2 % in the no-AF group and 2.2 % in the AF group (p = 0.74). Conclusion: This study of elderly patients reveals some novel predictors of post-CABG AF, most notably preoperative renal insufficiency and EuroSCORE. It is important to identify risk factors for post-CABG AF in all patient groups as this knowledge might lead to better prevention of this problem and its potential consequences.Öğe Behçet hastalarında stresli yaşam olayları ve başa çıkma yöntemleri ile hastalık belirtileri arasındaki ilişkinin araştırılması(Türk Psikiyatri Dergisi, 2001) Karlıdağ, Rifat; Evereklioğlu, Cem; Ünal, Süheyla; Sipahi, Birsen; Er, Hamdi; Yoloğlu, SaimÖz: Amaç: Behçet hastalarında stres etkenleri ve sorunlarla başa çıkma yöntemleri ile hastalığın fiziksel ve ruhsal belirtileri ile arasındaki ilişkinin araştırılmasıdır. Gereç ve yöntem: 36 Behçet hastası Sosyodemografik Veri Toplama Formu, Kısa Semptom Tarama Envanteri (KSE), Beck Depresyon Ölçeği (BDÖ), Beck Anksiyete Ölçeği (BAÖ) ve Spielberger Durumluk/Sürekli Kaygı Ölçeği (STAI I-II) kullanılarak değerlendirildi. Bulgular: Hastalığın akut başladığını belirten hastalarda KSE-depresyon (p<0.05), KSE-psikotizm (p<0.01) ve STAI-II puanlan, hastalığın görme sorunlarına neden olduğunu belirtenlerde BDÖ puanları anlamlı olarak daha yüksek bulunmuştur (p<0.05). Sağlık sorunlarıyla uğraşmakta zorlananlarda KSE-depresyon, KSE-Rahatsızlık Ciddiyeti İndeksi ve KSE-Semptom Rahatsızlık İndeksi puanları, günlük işlerini yapmakta güçlük çekenlerde BDÖ puanları, sosyal ilişkilerini sürdürmekte güçlük yaşayanlarda ve toplumsal, olaylardan etkilenenlerde KSE-anksiyete puanları anlamlı olarak yüksekti (p<0.05). Ekonomik güçlük yaşayanlarda KSE-hostilite (p<0.01), KSE-obsesif-kompulsif (p<0.001), KSE-Rahatsızlık Ciddiyeti İndeksi ve KSE-Semptom Rahatsızlık İndeksi puanları anlamlı düzeyde yüksekti (p<0.05). Sonuç: Psikososyal sorunlar hem hastalığın ortaya çıkması sürecinde, hem de ortaya çıkardığı ikincil sorunlar aracılığı ile süregenleşme döneminde önemli rol oynuyor gibi görünmektedir.Öğe Choice of medication for radial artery vasodilation in patients awaiting coronary artery bypass grafting(Türk Göğüs Kalp Damar Cerrahisi Dergisi, 2011) Erdil, Nevzat; Nisanoğlu, Vedat; Eroğlu, Tamer; Tüten, Recep; Cihan, Hasan Berat; Kutlu, Ramazan; Battaloğlu, Bektaş; Yoloğlu, SaimBackground: In this study, the vasodilatory effects of calcium antagonists and beta-blockers were investigated. Methods: After obtaining Faculty Ethics Committee approval and written informed consent from the patients, 72 adult patients (50 males, 27 females; mean age 62.9±9.3 years; range 37 to 75 years) who will undergo elective coronary artery bypass grafting (CABG) surgery were included in this study. We evaluated the vasodilatory effect of diltiazem alone (group 1), nifedipine alone (group 2), amlodipine alone (group 3), nebivolol alone (group 4) and nifedipine in combination with metoprolol (group 5). Seventy-seven patients who would undergo isolated CABG using radial artery were prospectively randomized to oral agents four or five days before operation. The dilatation of the lumen diameter and area of the radial artery were evaluated with high-resolution ultrasonography just before and 4-5 days after medical treatment. Results: Diltiazem alone group (p=0.058) and niphedipine in combination with metoprolol group (p=0.067) did not show a significant increase in the lumen diameter and area after medical treatment compared to the pretreatment values. Statistically significant increases in lumen diameter and area were observed in nifedipine (p=0007), amlodipine (p=0.003) and nebivolol (p=0.047) groups. Conclusion: Our results demonstrate that calcium channel antagonists are not equally effective in radial artery vasodilatation. Nifedipine, amlodipine and nebivolol appear to be the most effective agents in reducing radial artery spasm. Nebivolol is a betablocker and also has a potent vasodilatory effect on radial artery vasospasm.Öğe Çocukluk Çağı Basit Obezitesinde Eritrosit Sedimantasyon Hızı(Turgut Özal Tıp Merkezi Dergisi, 1998) Kutlu, Nurettin Onur; Gülcan, Hande; Yakıncı, Cengiz; Yoloğlu, SaimObez çocuklarla sağlıklı çocuklardaki eritrosit sedimantasyon hızını ve bunu etkileyen faktörleri araştırmak amacıyla; yaşları 6-12 arasında değişen (ortalama 9.13± 1.81 yıl) 21’i erkek ve 9’u kız olmak üzere toplam basit obez 30 çocuk ile yaşları 6-13 arasında değişen (ortalama 9.13± 1.69 yıl) 14’ü erkek ve 16’sı kız olmak üzere kontrol grubunu oluşturan 30 sağlıklı çocuk çalışmaya alındı. Obezite durumu BMl’e (Body Mass Index) göre hesaplandı. Her iki grupta eritrosit sedimantasyon hızı, total kolesterol ve trigliserid düzeylerine bakıldı. Eritrosit sedimantasyon hızı değerleri ve bunu etkileyebilecek total kolesterol ile trigliserid düzeyleri birbirleriyle karşılaştırıldı. Obez çocuklarda kontrol grubuna göre yaş ve cinsiyet faktöründen bağımsız olarak eritrosit sedimantasyon hızı, total kolesterol ve trigliserid düzeyleri kontrol grubuna göre anlamlı olarak yüksek bulundu (p< 0.001). BMI ile eritrosit sedimantasyon hızı, total kolesterol ve trigliserid düzeyleri arasında anlamlı bir korelasyon tespit edilemedi. (p> 0.05). [Turgut Özal Tıp Merkezi Dergisi 1998;5(l):52-54]Öğe Comparative analysis of models in confirmatory factor analysis: Exploring clinical applications and interpretation(2023) İnceoğlu, Feyza; Yoloğlu, Saim; Kanık, Arzu EmineTo demonstrate the explainability of the scales with fewer dimensions instead of the number of existing dimensions by ensuring that the scale structures created by explanatory factor analysis (EFA) are verified with confirmatory factor analysis (CFA). Data from the Nutritional Behavior Scale in Children, answered by the parents of 204 children with autism spectrum disorder (ASD) were used. EFA was performed with the data obtained from the scale. In the next step, the explained variance percentages and dimensions were determined and the model goodness of fit indexes were calculated with CFA. The dimensions with the lowest explained variance percentages were removed from the model, respectively, and three different scale models were tested. The variance explanation percentage of the first eight-dimensional model created with EFA was calculated as 72.68%. The food fussiness sub-dimension was removed and CFA was applied to the model again and new indices were calculated. Finally, the emotional under-eating sub-dimension was excluded from the model, resulting in a six-dimensional Child Eating Behavior Scale (CEBS). Goodness-of-fit indices of the CFA model established with six dimensions were ?2 / df; 1.545, AIC; 715,433 and RMSEA; 0.052 was found. It has been shown that the eight, seven, and six-dimensional scale models constructed according to the percentages of variance explained for CEBS are sufficient to explain the sample and that the six-dimensional scale model can be used for CEBS. Our study is the first to use competing models in confirmatory factor analysis in reducing scale dimensions.Öğe Comparison of intravenous ibuprofen and acetaminophen for postoperative multimodal pain management in bariatric surgery: A randomized controlled trial(ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA, 2018) Şanlı, Mukadder; Kırteke, Ramazan; Yoloğlu, SaimStudy objective: Multimodal analgesic strategies are recommended to decrease opioid requirements and opioid-induced respiratory complications in patients undergoing laparoscopic bariatric surgery. Recent studies have demonstrated that intravenous ibuprofen decreases opioid consumption compared with placebo. The primary aim of this study was to compare the effect of intravenous ibuprofen and intravenous acetaminophen on opioid consumption. We also aimed to compare postoperative pain levels and side effects of the drugs. Design: Randomized, double-blinded study. Setting: University hospital. Patients: Eighty patients, aged 18-65 years, (ASA physical status undergoing laparoscopic sleeve gastrectomy or laparoscopic Roux-en-Y gastric bypass surgery were included in this study. Interventions: Patients were randomized to receive 800 mg ibuprofen or 1 g acetaminophen intravenously every 6 h for the first 24 h following surgery; in addition, patient-controlled analgesia with morphine was administered. Measurements: Postoperative morphine consumption in the first 24 h, visual analog scale (VAS) pain scores at rest and with movement, and opioid related side effects were assessed. In addition, time to passage of flatus, surgical complications, lengths of intensive care unit and hospital stay, and laboratory parameters were recorded. Main results: The mean morphine consumption was 23.94 +/- 13.89 mg in iv ibuprofen group and 30.23 +/- 13.76 mg in the acetaminophen group [mean difference: -6.28 (95% CI, -12.70, 0.12); P = 0.055]. The use of intravenous ibuprofen was associated with reduction in pain at rest (AUC, 1- to 24-h, P < 0.001 and 12- to 24-h, P = 0.021) and pain with movement (AUC, 1-24, 6-24, and 12-24 h, P < 0.001). Intravenous ibuprofen was well tolerated with no serious side effects except dizziness. Conclusions: Intravenous ibuprofen did not significantly reduce opioid consumption compared to intravenous acetaminophen; however, it reduced the severity of pain. Intravenous ibuprofen may be a good alternative to intravenous acetaminophen as part of a multimodal postoperative analgesia in patients undergoing bariatric surgery.Öğe A comparison of multivariate statistical methods to detect risk factors for type 2 diabetes mellitus(2023) Çiçek, İpek Balıkçı; Yoloğlu, Saim; Şahin, İbrahimAim: The goal of this study is to compare the performances of Logistic Regression (LR), Artificial Neural Networks (ANN) and Decision Tree models, which are machine learning classification methods, in the diagnosis of type 2 Diabetes Mellitus (DM) and to determine the most successful method. It is also the examination of risk factors affecting type 2 DM using these models. Materials and Methods: The study’s data was collected from patients who visited the Diabetes and Thyroid polyclinic at the Inonu University Faculty of Medicine Turgut Ozal Medical Center, Department of Internal Medicine. The k-Nearest Neighbor algorithm, which is one of the missing value assignment methods, was used to eliminate the prob- lems related to missing values. Sensitivity, accuracy, precision, specificity, AUC F1-score, and classification error were used as performance evaluation criteria. Evolutionary algo- rithm parameter optimization method was used to optimize the parameters of the ANN model. Missing value assignment, modeling and parameter optimization were done with Rapidminer Studio Free version 8.1. Results: Among the three methods applied in the diagnosis of type 2 DM, the ANN gave the best classification performance. The accuracy, sensitivity, selectivity, precision, F1-score, AUC and classification error values obtained from this method are respectively; 98.94%, 100%, 97.73%, 98.04%, 99.01%, 0.978 and 1.06. For the ANN method, the im- portance values of the gender, long-term drug use, family history, concomitant disease, cortisone use, stress factor, high blood pressure, smoking, high cholesterol, heart dis- ease, exercise status, carbohydrate use, alcohol consumption, vegetable use, meat use, age, weight, height, starting age, daily bread consumption, LDL, HDL, Total Cholesterol, Triglyceride, Fasting blood sugar the importance values of independent variables are re- spectively; 0.017, 0.009, 0.013, 0.017, 0.008, 0.016, 0.008, 0.006, 0.053, 0.024, 0.023, 0.040, 0.007, 0.020, 0.007, 0.046, 0.083, 0.049, 0.024, 0.066, 0.084, 0.083, 0.020, 0.031, 0.244. Conclusion: According to the performance criteria obtained from the three classifica- tion models used to predict type 2 DM; it has been found that the best classification performance belongs to the ANN model. According to the ANN method, the three most important risk factors that may cause type 2 DM were found to be fasting blood glucose, LDL, and HDL, respectively.
