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    HBsAg Screening in the Family Members of the Patients with Chronic Hepatitis B
    (Galenos Yayincilik, 2007) Kayabas, Uner; Bayindir, Yasar; Yologlu, Salim; Akdogan, Dogan
    Hepatitis B is one of the most common viral infections around the world. It is estimated that two billion people have been infected with hepatitis B virus and higher than 350 million have chronic hepatitis B. The aim of this study was to determine HBsAg positivity in the family members of index cases with chronic hepatitis B. Totally 375 subjects who were admitted to our outpatient clinic of Infectious Diseases between 2000 and 2003, were included in this study. Eighty-eight of them were index cases that were detected as HBsAg positive while 287 of them were the family members of the index cases. Thirty (34.1%) of the index cases were female and 58 (65.9%) were male. One hundred and fifty eight (55.1%) of the family members were female, 129 (44.9) were male. There were 36 HBsAg positive family members, 20 (55.5%) of them were male, 16 (44.5%) of them were female (p>0.05). The mean age of HBsAg positive family members and HBsAg negative family members were 26.5 +/- 14.7 (6-58) and 20.1 +/- 14.2 (range 1-60) (p=0.01), respectively. HBsAg positivity of fathers was higher than mothers (p=0.0003). HBsAg positivity was higher in off-springs of families that both parents have HBsAg positivity than families with mother-negative but father-positive HBsAg positivity (p<0.0001). In conclusion, intra-familial transmission is very important for HBV, therefore the family members of HBsAg positive index cases should be screened for HBsAg and if necessary they should be vaccinated.