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Airway management using the ProSeal™ laryngeal mask airway in a child with Goldenhar syndrome
(Verduci Publisher, 2012) Aydogan, M. S.; Begec, Z.; Erdogan, M. A.; Yucel, A.; Ersoy, M. O.
Children with congenital anomalies such as Goldenhar syndrome affecting the airway can be a problem for the anaesthesiologist. We present the case of an 18 month-old child with Goldenhar syndrome, in whom the ProSeal (TM) Laryngeal Mask Airway was successfully used for inguinal hernia surgery.
Characterization of thermoluminescence kinetic parameters of beta irradiated B doped Ca5(PO4)3OH powder obtained from eggshell
(Pergamon-Elsevier Science Ltd, 2021) Depci, T.; Oglakci, M.; Sezer, S.; Yucel, A.; Dogan, T.; Souadi, G.; Topaksu, M.
In this study, we have synthesized B doped Ca5(PO4)3OH (HAP) by a sonication chemical method. The thermoluminescence (TL) properties of the family of synthesized samples (B doped Ca5(PO4)3OH (HAP) were investigated using an IRSL-TL 565 nm filter. This gave the highest TL intensity of each phosphor after 2 Gy beta-irradiation. Three TL glow peaks of B doped Ca5(PO4)3OH (HAP) are centered at around 84, 208 and 324 degrees C (with a heating rate of 2 degrees Cs-1). The trapping parameters such as activation energy (E), order of kinetics (b), frequency factor (s) were calculated by using initial rise (IR), various heating rates (VHR) and computerized glow curve deconvolution (CGCD) method. The response of TL glow curves remained constant within +/- 5% deviation from the initial value after 9 cycles of reuse; but only at tenth cycle the deviation goes up to 6%.
Determination of dosimetric properties of MgO doped natural amethyst samples
(Pergamon-Elsevier Science Ltd, 2016) Nur, N.; Guckan, V.; Kizilkaya, N.; Depci, T.; Ahmedova, C.; Yucel, A.; Ozdemir, A.
In this paper, the thermoluminescence (TL) dosimetric characteristics of MgO doped natural amethyst samples (Mg-NA) are presented. The morphologies and chemical structures of the powder form samples were identified using XRD, FTIR, SEM, SEM mapping and EDX. Comparison of the TL intensities showed that 10 wt% Mg-NA was nearly 150 times more sensitive than undoped amethyst and the main dosimetric properties proved that 10 wt% Mg-NA may be a promising phosphor for clinical and radiotherapy purposes. (C) 2016 Elsevier Ltd. All rights reserved.
Effect of Preoperative Iron Deficiency in Liver Transplant Recipients on Length of Intensive Care Unit Stay
(Elsevier Science Inc, 2013) Aydogan, M. S.; Ozgul, U.; Erdogan, M. A.; Yucel, A.; Toprak, H. I.; Durmus, M.; Colak, C.
Liver transplant (LT) recipients often display iron deficiency preoperatively, which significantly increases the quantity of blood that needs to be transfused intraoperatively, A risk factor for a prolonged intensive care unit (ICU) stay. The aim of this retrospective study was to determine whether there was a clinically significant association between iron deficiency and the length of ICU stay, among 153 patients scheduled for OLT from September 2011 to June 2012. Patients were divided into 2 groups according to their baseline iron status: iron- deficient (ID) and non-ID (normal iron profile) cohorts. Iron deficiency was assessed on the basis of several parameters; transferrin saturation as well as serum iron, ferritin, soluble transferrin receptor, and C-reactive protein levels. We retrospectively analyzed the data regarding demographic and clinical features, preoperative laboratory values, intraoperative transfusions, and length of ICU stay. Patient demographic features and preoperative values were similar between the groups. Preoperative iron deficiency, which was diagnosed in 72 patients (58.6%), was associated with a greater intraoperative use of fresh frozen plasma and red blood cell transfusions (P = .0001). The median length of ICU stay after LT was longer among the ID versus the non-ID group (5 and 3 days per patient, respectively; P = .0001). Therefore, we have suggested that preoperative iron deficiency may be a prognostic factor for the length of ICU stay after LT.
Effects of Apocynin on Liver Ischemia-Reperfusion Injury in Rats
(Elsevier Science Inc, 2019) Yucel, A.; Aydogan, M. S.; Ucar, M.; Sarici, K. B.; Karaaslan, M. G.
Objective. Ischemia-reperfusion (IR) injury is associated with various clinical conditions, such as myocardial infarction, shock, and surgery under vascular occlusion. We aimed to investigate the protective and therapeutic effects of apocynin (AP) on liver injury induced by IR in an in vivo rat model. Methods. Thirty-two rats were randomly divided into 4 experimental groups with n = 8 in each group: sham, IR, AP, and IR + AP. AP (20 mg/kg) was intraperitoneally administered to rats in the AP and IR + AP groups for 30 minutes before 60 minutes of ischemia and followed by 60 minutes of reperfusion. All rats were killed on the same day to evaluate tissue levels of oxidants and antioxidants (catalase, malondialdehyde, myeloperoxidase, superoxidedismutase (SOD), and total glutathione). Results. IR decreased SOD levels in IR group when compared with the sham group. AP supplementation to IR group significantly ameliorated SOD levels (P < .05). Also, IR caused elevation of myeloperoxidase production when compared with the sham group, whereas AP treatment prevented these hazardous effects (P < .05). However, plasma total glutathione, catalase, and malondialdehyde levels did not differ between the AP + IR and the IR rats. Conclusion. The main finding of the present study was that AP may be protective against liver IR injury. Our results suggested that AP pretreatment suppressed oxidative stress and increased antioxidant levels in an rat model of liver IR.
The effects of ephedrine on maternal hypothermia in caesarean sections: a double blind randomized clinical trial
(Verduci Publisher, 2013) Gulhas, N.; Tekdemir, D.; Durmus, M.; Yucel, A.; Erdil, F. A.; Yologlu, S.; Ersoy, M. O.
BACKGROUND: The purpose of the study was to investigate the effect of bolus and the combination of bolus and infusion of ephedrine on maternal hypotermia which are used for treating maternal hypotension under spinal anaesthesia. PATIENTS AND METHODS: 110 ASA I-II patients who developed maternal hypotension were included into the study. Spinal anaesthesia was performed with 12.5 mg heavy bupivacaine + 15 mu g fentanyl. Group I: Ephedrine bolus 5 mg plus ephedrine infusion, Group B: Ephedrine bolus 5 mg plus normal saline infusion. The systolic blood pressure was allowed to range between 20% from baseline values. Ephedrine solution infusion started after hypotension occurred (0.5 mg/minute). The body temperature under 35.5 degrees C was accepted as hypothermia. The newborns' rectal temperature was measured. Moreover, the Apgar scores, umbilical vein-arterial blood gas and acid-base status were evaluated. RESULTS: In Group I, the body core temperatures which were measured at 9, 18, 33, and 39th minutes were significantly higher than Group B (p < 0.05). The prevalence of maternal hypothermia in Group I was significantly lower than the Group B, which were as 65.5% (36/55) and 85.5% (47/55), respectively (p < 0.05). In Group I, the newborn rectal temperatures and the total dose of ephedrine were significantly higher than Group B (p < 0.05). In Group I, the systolic and mean blood pressures were higher than Group B (p < 0.05). CONCLUSIONS: As a result, we found that combined bolus and infusion of ephedrine for treating maternal hypotension prevents maternal and neonatal hypothermia during caesarean section under spinal anaesthesia compared to bolus administrations alone.
Effects of Oral ?- Glucan on Liver Ischemia/Reperfusion Injury in Rats
(Elsevier Science Inc, 2013) Aydogan, M. S.; Yucel, A.; Erdogan, M. A.; Polat, A.; Cetin, A.; Ucar, M.; Duran, Z. R.
Aim. Ischemia/reperfusion (IR) injury (IRI) in liver transplant patients may negatively affect graft function. Although beta-glucan protects kidneys against IRI, its effect on the liver is unknown. This study sought to investigate beta-glucan effects on oxidative damage to the liver after IRI in rats. Materials and Methods. Thirty-two rats were randomly divided into 4 experimental groups n = 8 in each group: sham, IR, beta-glucan and IR + beta-glucan. beta-Glucan (50 mg kg(-1) . day(-1)) was orally administered for 10 days to rats in the beta-glucan and IR + beta-glucan groups. The rats in the IR and IR + beta-glucan groups were subjected to ischemia and reperfusion (IR) for 60 minutes each. All rats were killed on day 11 to evaluate histological changes as well as tissue levels of oxidants and antioxidants. Results. Malondialdehyde (MDA) levels were significantly higher in the IR than the sham group (P = .001). MDA level was significantly higher in the IR group than in the IR + beta-glucan group (P = .001). The levels of tissue antioxidant markers (superoxide dismutase [SOD], glutathione-peroxidase [GPx], and catalase [CAT]) were significantly lower in the IR group than in the sham group (P < .05). SOD and GPx levels did not differ significantly between the IR and IR + beta-glucan groups. CAT activity was significantly higher in the IR than the IR + beta-glucan group (P = .001). Histological tissue damage was reduced in the IR + beta-glucan than the IR group. Conclusion. Liver IRI is an inevitable problem during liver surgery. Our results suggested that beta-glucan pretreatment suppressed oxidative stress and increased antioxidant levels in an rat model of liver IRI.
Effects of Preoperative Iron Deficiency on Transfusion Requirements in Liver Transplantation Recipients: A Prospective Observational Study
(Elsevier Science Inc, 2013) Aydogan, M. S.; Erdogan, M. A.; Yucel, A.; Konur, H.; Bentli, R.; Toprak, H. I.; Durmus, M.
The aims of this study were to determine the frequency of preoperative iron deficiency in adult living donor liver transplantation patients and to investigate its relationship with the need for intraoperative transfusion. Between September 1, 2011, and June 1, 2012, 103 patients scheduled for liver transplantation were included in this prospective study. Patients were divided into 2 groups according to baseline iron status: an iron-deficient group and a non deficient (normal iron profile) group. Iron deficiency was assessed on the basis of several parameters, including transferrin saturation, levels of ferritin, soluble transferrin receptor, C-reactive protein, and peripheral blood smear. Preoperative iron deficiency was diagnosed in 62 patients. Preoperative iron deficiency was associated with low preoperative hemoglobin levels (P = .01) and a high rate of intraoperative transfusion (P < .0001). Preoperative iron deficiency is prognostic factor for predicting intraoperative transfusion requirements. These findings have important implications for transfusion practices for liver transplant recipients.
Evaluation of the effects of ozone therapy on Escherichia coli-induced cytitis in rat
(Springer London Ltd, 2013) Tasdemir, C.; Tasdemir, S.; Vardi, N.; Ates, B.; Onal, Y.; Erdogan, S.; Yucel, A.
The aim of the study was to investigate the effect of ozone on oxidative/nitrosative stress and bladder injury caused by Escherichia coli in rat bladder. Twenty-one Wistar-Albino-type female rats included in the study were divided into three groups of equal number: (1) sham operation (control), (2) E. coli-only (EC), (3) EC + ozone. After ozone therapy for 3 days, urine and tissue samples were obtained for biochemical, microbiological, and histopathological analysis. Tissue malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) level were increased, whereas superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity was decreased in the EC group. MDA, MPO, and NO levels were decreased, whereas SOD, GPx activity was increased in the ozone-treated group. Also, there was no bacterial translocation in this group. The results of the present study suggest that ozone may be used as an agent to protect the bladder from oxidative/nitrosative stress occurring in cystitis.
Foodborne botulism: 4 cases report
(Elsevier Ireland Ltd, 2016) Bicakcioglu, M.; Aydogan, M. S.; Yucel, A.; Togal, T.
[Abstract Not Available]
Ketofol (mixture of ketamine and propofol) administration in electroconvulsive therapy
(Australian Soc Anaesthetists, 2012) Kayhan, G. Erdogan; Yucel, A.; Colak, Y. Z.; Ozgul, U.; Yologlu, S.; Karlidag, R.; Ersoy, M. O.
The aim of this study was to evaluate the effect of a ketamine:propofol combination ('ketofol') for electroconvulsive therapy on seizure activity, haemodynamic response and recovery parameters, and to compare with these with the effects of propofol alone. Twenty-four patients underwent a total of 144 electroconvulsive therapy sessions, allocated in this prospective, double-blind, crossover study. Patients were randomly assigned to receive 1 mg/kg ketofol (0.5 mg/kg propofol plus 0.5 mg/kg ketamine) or 1 mg/kg propofol 1% for anaesthesia induction. Seizure duration and quality, haemodynamic data, recovery parameters and side-effects were recorded and analysed between groups. Both motor and electroencephalography seizure durations in the ketofol group (29 +/- 17 and 41 +/- 17 seconds, respectively) were similar to that in the propofol group (28 +/- 13 and 38 +/- 16 seconds, respectively). Postictal suppression index was higher in the ketofol group (89.63 +/- 7.88) than in the propofol group (79.74 +/- 14.6) (P <0.05). In the ketofol group, heart rate after the seizure ended and mean arterial pressures, recorded at 0 and 5 minutes after the seizure ended, were higher than in the propofol group. Time to obeying commands was longer in the ketofol group (P <0.05). There were no untoward psychological reactions following ketofol. Although no superiority to propofol in terms of seizure duration, haemodynamic or recovery parameters was found, the ketofol mixture selected in our study provided better seizure quality than propofol. We conclude that ketofol can be an alternative strategy to enhance the seizure quality and clinical efficiency of electroconvulsive therapy.
A new activator strontium for magnesium tetraborate: PL and TL studies
(Pergamon-Elsevier Science Ltd, 2016) Evis, D.; Yucel, A.; Kizilkaya, N.; Depci, T.; Kafadar, V. E.; Ozturk, E.; Yildirim, R. G.
Strontium was used for the first time as an activator agent for magnesium tetraborate (MBO) and photoluminescence (PL) and thermoluminescence (TL) properties were determined using a spectrophotometer and a TL reader, respectively. The results proved that 0.25 wt% Sr ratio played an important role in prolonging the afterglow and the phosphor gave the main TL peak with the highest intensity at 200 degrees C like an ideal case. Therefore, it is worthwhile to carry out continuous and systematic research on it (C) 2016 Elsevier Ltd. All rights reserved.
Remifentanil without muscle relaxants for intubation in microlaryngoscopy: a double blind randomised clinical trial
(Verduci Publisher, 2013) Gulhas, N.; Topal, S.; Kayhan, G. Erdogan; Yucel, A.; Begec, Z.; Yologlu, S.; Durmus, M.
OBJECTIVES: We aimed to compare the effect of remifentanil without muscle relaxant with succinylcholine for intubation in microlaryngoscopy. PATIENTS AND METHODS: Eighty patients were randomly divided into two groups: Group R (n=40) and S (n=40) received remifentanil 4 mu g/kg intravenously or 1 mu g/kg respectively. Anesthesia was induced with 2 mg/kg propofol in both groups. Intubation was performed after bolus administration of 10 ml saline as a placebo or 1 mg/kg of succinylcholine in Group R and S respectively. Remifentanil infusion was initiated at 0.025 mu g/kg in each groups. RESULTS: Intubation conditions were similar in both groups. The mean arterial pressure (MAP) values at post-induction period were significantly lower in the Group S than in the Group R (p = 0.001). The requirement for ephedrine in Group R was found to be significantly lower than Group S (p = 0.023). Recovery times were significantly shorter (p = 0.001) and recovery scores were significantly higher (p = 0.021) in Group R. Time to patient could respond to commands was significantly longer in the Group S (p = 0.001). The surgeon's satisfaction score was significantly higher in Group R (p = 0.001). CONCLUSIONS: It was concluded that remifentanil without muscle relaxants provides similar intubating conditions as that provided by succinylcholine, and remifentanil is superior to succinylcholine with regard to haemodynamic stability and recovery duration.
Single intrathecal fentanyl for combined spinal epidural anesthesia confers no advantage over hemodynamic effects in elderly patients
(Verduci Publisher, 2012) Yucel, A.; Gulhas, N.; Aydogan, M. S.; Erdogan, M. A.; Beytur, A.; Tasdemir, C.; Ersoy, M. O.
Background: Neuroaxial blockade for ambulatory transurethral resection of the prostate is a well established technique. Patients in this group are often at high risk for perioperative complications from concurrent diseases. The purpose of this study was to compare the elderly patients who received intrathecal fentanyl alone or intrathecal fentanyl plus bupivacaine or epidural anesthesia for transurethral resection of prostate surgery. Material and Methods: Ninety-nine patients were prospectively randomized to receive fentanyl 25 mu g (Group F), fentanyl 25 mu g plus hyperbaric bupivacaine 2.5 mg (Group BF), or epidural anesthesia adding fentanyl 50 mu g (Group E) by combined spinal epidural anesthesia technique. Results: The amount of local anesthetics used until when the sensorial block reached the level of T10 was significantly lower in the Group BF than in the Group E and the Group F (p < 0.001). Maximum level of sensory block was significantly lower in the Group BF than in the Group E and the Group F (p = 0.01). The time elapsed until the sensory block reached T10, the regression of sensory block to L5 level were significantly lower in the Group BF than in the Group E and the Group F (p = 0.005, p < 0.001, respectively). Compared to the basal values, mean arterial pressures were significantly lower in the Group BF than in the Group E and the Group F (p < 0.05). The occurrence of hypotension was significantly lower in the Group BF (9.4%) than in the Group E (18.2%) and the Group F (24.2%). Conclusions: Intrathecal hyperbaric bupivacaine 2.5 mg plus fentanyl 25 mu g administration provides shorter motor block onset time, less local anesthetic usage and adequate hemodynamic stability in elderly patients.
Tracheomediastinal emphysema after tracheostomy in a post-COVID-19 patient: a case report
(Verduci Publisher, 2022) Bicakcioglu, M.; Demircan, S.; Yucel, A.; Ozer, A. B.
OBJECTIVE: There are no reports of tracheomediastinal fistula development after tracheostomy. CASE REPORT: A 72-year-old female patient with post acute COVID-19 was transferred to our intensive care unit. After two unsuccessful weaning attempts, a tracheostomy was performed at hospitalization on day 32. The patient's body mass index was 35 kg/m2 and she had a narrow neck anatomy. A percutaneous tracheostomy was performed using the Griggs method without any problems. Pneumothorax, pneumomediastinum, subcutaneous emphysema, and hemorrhage were not observed. Twenty-two days after the tracheostomy, the patient developed subcutaneous emphysema and experienced a sudden decrease in oxygen saturation. Bedside anterior-posterior chest X-ray did not detect pneumothorax and a tracheoesophageal fistula was found via esophageal endoscopy. A tracheomediastinal fistula was observed just below the cannula distal end via computed tomography. CONCLUSIONS: There are multiple reasons why a tracheomediastinal fistula could develop after tracheostomy. Therefore, this condition should be considered in cases of sudden subcutaneous emphysema and oxygen deterioration following tracheostomy.

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