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Öğe Efeitos antimicrobianos de cetamina em combinação com propofol: Um estudo in vitro(Elsevier Editora Ltda, 2013) Begec Z.; Yucel A.; Yakupogullari Y.; Erdogan M.A.; Duman Y.; Durmus M.; Ersoy M.O.[No abstract available]Öğe Effects of dexmedetomidine and midazolam on motor coordination and analgesia: A comparative analysis(2013) Aydogan M.S.; Parlakpinar H.; Ali Erdogan M.; Yucel A.; Ucar M.; Sa?ir M.; Colak C.Objective: We compared the effects of 2 sedative drugs, dexmedetomidine and midazolam, on motor performance and analgesic efficacy in a rat model. Materials and methods: Rats were randomly divided into the following 4 groups on the basis of the treatment received. The first group received 83 ?g/kg/min midazolam; the second, 1 ?g/kg/min dexmedetomidine; the third, 83 ?g/kg/min morphine; and the fourth was a control group. The rats were measured motor coordination and pain reflexes by using rotarod, accelerod, hot plate, and tail flick tests. Results: At all the tested speeds, the midazolam-injected rats remained on the rotarod longer than did the dexmedetomidine-injected rats. Furthermore, in the 10-minute accelerod test, the midazolam-injected rats remained for a longer duration than did the dexmedetomidine-injected rats. The latency time for the hot plate test was significantly higher at 10 minutes and 20 minutes in the dexmedetomidine group than in the midazolam group. Further, the latency time at 10 minutes for the tail flick test was greater in the dexmedetomidine group than in the midazolam group. Conclusions: In this rat model, midazolam results in faster recovery of motor coordination performance when compared with dexmedetomidine. © 2013 The Authors.Öğe The effects of intra-operative low-dose dexmedetomidine infusion on postoperative pain in patients undergoing septorhinoplasty(Maney Publishing, 2006) Cicek M.; Yucel A.; Gedik E.; Sagir O.; But A.K.; Ersoy M.O.Study objective: To determine the effects of intra-operative low-dose dexmedetomidine infusion on postoperative morphine consumption, pain, sedation and patient satisfaction in patients undergoing septorhinoplasty. Method: Fifty adult patients were randomised to receive either dexmedetomidine (a loading dose of 1 ?g kg-1 for the first ten minutes and a maintenance dose of 0.2 ?g kg-1 h-1 afterwards, Group D) or 0.9% saline in the same manner (Group C) after induction of anaesthesia. At the end of the operation, the infusions were discontinued. After extubation, patient controlled analgesia was started intravenously. Results: Patients in Group D consumed 47% less morphine than patients in Group C during the first 24 h and had a lower cumulative morphine consumption at all times after starting patient controlled analgesia (7.08 mg vs. 8.56 mg at 2 h (p < 0.05), 10.84 mg vs. 14.0 mg at 4 h (p < 0.05), 13.56 mg vs. 18.28 mg at 6 h (p < 0.05) and 17.96 mg vs. 33.72 mg at 24 h (p < 0.05), respectively in Group D and Group C). Visual analogue scale scores for pain were higher at all times in Group C than in Group D (p < 0.05). Sedation scores were higher in Group D than in Group C at 30 min after starting patient controlled analgesia (p < 0.05). Patient satisfaction scores were higher at all times in Group D than in Group C (p < 0.05). Conclusions: Intra-operative low-dose dexmedetomidine infusion during septorhinoplasty decreases postoperative morphine consumption, provides effective postoperative pain relief and achieves better patient satisfaction without increased adverse effects. © 2006 VSP.Öğe Effects of Perineural Administration of Dexmedetomidine in Combination with Levobupivacaine in a Rat Sciatic Nerve Block(2013) Ali Erdogan M.; Polat A.; Yucel A.; Aydogan M.S.; Parlakpinar H.; Tekin S.; Durmus M.Objective: The aim of this study was to assess if perineural administration of dexmedetomidine combined with levobupivacaine increases the duration of the sensory and motor blockade of a sciatic peripheral nerve block in rats. Methods: Forty male Sprague-Dawley rats were randomly divided into 5 experimental groups: Group 1, sham; Group 2, perineural levobupivacaine (0.2 mL of a 0.5% solution) and subcutaneous saline; Group 3, perineural levobupivacaine (0.2 mL of a 0.5% solution) plus dexmedetomidine (20 ?g/kg dexmedetomidine) and subcutaneous saline; Group 4, perineural saline and subcutaneous dexmedetomidine; and Group 5, perineural saline and subcutaneous saline. Pain reflexes in response to a thermal stimulus were measured at 0 and 240 minutes after drug administration by using a hot-plate and tail-flick tests. Neurobehavioral status, including sensory and motor functions, was assessed by an investigator who was blinded to the experimental groups every 30 minutes until normal functioning resumed. Results: The sensory and motor blockades of the rats did not increase in the treatment with dexmedetomidine plus levobupivacaine when compared with the treatment with levobupivacaine alone at all the time points ( P > 0.05). Compared with rats in Group 2, those in Group 3 showed significantly higher latency times at 30 and 60 minutes in the hot plate test ( P < 0.01). At 30 and 60 minutes, the latency times of the rats in Group 3 were longer than those in Group 2 in the tail-flick test ( P < 0.01). Furthermore, the durations of the complete sensory and motor blockade were similar when treatment with levobupivacaine plus dexmedetomidine was compared with treatment with levobupivacaine alone. Conclusions: A 20?g/kg dose of dexmedetomidine added to levobupivacaine did not increase the duration of the sensory and motor blockades in rats. However, treatment with dexmedetomidine plus levobupivacaine increased the quality of analgesia in rats. © 2013 The Authors.Öğe Volume comparison of caudal bupivacaine for inguinal hernia repair in children(2010) Dogan Z.; Yucel A.; Senoglu N.; Oksuz H.; Yildiz H.; Bakan V.; Ozkan K.U.Background: The efficacy of two different volumes of 0.25% bupivacaine for caudal blockade, in children undergoing inguinal hernia repair surgery regarding hernia pouch traction, was evaluated. Patients & Methods: Forty children aged between 1 to 5 years, undergoing elective inguinal herniorrhaphy or hydrocele repair were enrolled in the study. Patients received a caudal blockade either with bupivacaine 0.25% at 1.0 ml kg-1 (n=20), or bupivacaine 0.25% at 1.1 ml kg-1 (n=20). After caudal blockade inhalation Anaesthesia was stopped and Anaesthesia was maintained with a propofol infusion. Results: There were no significant differences between the groups with respect to sex distribution, age, weight, type of surgery, duration of Anaesthesia and surgery, and recovery time. None of patients developed a hemodynamic or respiratory problem. No nausea or vomiting was observed and no urinary retention was noted. The Anaesthesia onset time was shorter, the reached peak sensory level was higher, and duration of analgesia was longer in children receiving 1.1 ml kg-1. Total propofol consumption was statistically higher in children receiving 1.0 ml kg-1. Caudal Anaesthesia has been adequate to block the hernia pouch traction response during surgery in children receiving 1.1 ml kg-1. There were no significant differences between groups in the incidence of residual motor blockade. Conclusions: This study indicates that in children undergoing inguinal hernia repair surgery bupivacaine 0.25% at 1.1 ml kg-1 is more reliable.
