Yazar "Yucetas, Seyho Cem" seçeneğine göre listele

Listeleniyor 1 - 5 / 5
  • Küçük Resim
    Öğe
    Comparison of glutathion-s-transferase A-4 expression values between lumbar spinal canal stenosis and lumbar discal hernia patients
    (2019) Cakir, Tayfun; Yucetas, Seyho Cem
    Aim: To compare the glutathione s-transferase α-4 (GSTA4) isoenzymes expression values in patients with lumbar spinal canal stenosis (LSCS) due to ligamentum flavum (LF) hypertrophy with patients no evidence of LF hypertrophy.Material and Methods: 27 LF specimens were obtained from patients with LSCS and 27 LF specimens were obtained from patients with lumbar discal hernia (LDH). Firstly these LF samples were analyzed histologically to identify the fibrosis and elastin degradation values. Then GSTA4 isoenzyme values were measured and compared.Results: The mean LF thickness was significantly higher in the LSCS group than in the LDH group (6.72±0.86 and 3.1±0.7 mm, respectively, p 0.005). Average elastin degradation degree was significantly higher in the LSCS group than LDH group (4.4 ±0.50 vs. 0.18±0.1, respectively, p 0.001). And avarage fibrosis degree was significantly higher in the LSCS group than LDH group (4.41±0.17 vs. 0.96±0.11, respectively, p 0.001). And significantly higherexpression of GSTA4 izoenzyme was observed in the LF samples obtained from patients with LSCS compared with controls (144.1±11.16 vs 51.75±21.53, respectively, p=0.009). Conclusion: Our findings in this study suggest that there is a relationship between LF hypertrophy and GSTA4 isoenzyme expression.
  • Küçük Resim
    Öğe
    Comparison of surgery techniques for recurrent lumbar disc herniation: Total and parsiyel laminectomy
    (2020) Cakir, Tayfun; Yucetas, Seyho Cem
    Aim: The purpose of this study was to compare different surgical methods; hemi-laminectomy versus facet protective total laminectomy in recurrence lumbar discal hernia(rLDH) patients. Materials and Methods: The patients were categorized into 2 groups:34 patients underwent total laminectomy formed the group 1, and 31 patients underwent hemi-laminectomy formed group 2. Patients were compared in terms of age, sex, body mass index(BMI), duration of surgery, length of hospital stay and complications. After 3 years, visual analogue scale for leg and back pain(VASlp,bp), oswestry disability index(ODI) scores and presence of spinal instability were evaluated. Results: There was no significiantly differences about age, sex, BMI, operation segment, mean operative time and length of hospital stay. Significant improvement was observed in both groups in terms of VAS and ODI values. Dural tear was occurred in 8 patients in group 1 and 1 patient in group 2. Superficial wound infection was seen in 1 patient in group 2. Postop spinal instability was observed in 1 patient in group 2. Conclusion: Total laminectomy increased the duration of the operation, but significantly reduced the complication rates. In recurrent disc hernias facet protective total laminectomy may be used at especially in patients without evidence of spinal instability.
  • Küçük Resim
    Öğe
    The comparison of the mRNA expressions of TGFβ1, bFGF, IGF-1, NGF, and matrix metalloprotease III genes in cervical and lumbar degenerated disc tissues.
    (2018) Yucetas, Seyho Cem; Yilmaz, Atilla; Gulec, Elif; Ozic, Cem
    Aim: To evaluate and compare the mRNA expression of antioxidant genes between the cervical and lumbar degenerated disc tissues. Material and Methods: Obtained degenerated Nucleus Pulposus (DNP) materials were divided into two groups, which were cervical DNP (Group I) (n=20) and lumbar DNP (Group II) (n=20). There are 6 men and 14 women in group I with a mean age of 43.8 years and 13 men and 7 women in group II with the mean age of 40.3 years (28 to 54). All cervical DNP materials were obtained between C5 and C6 and all lumbar DNP materials were obtained between L4 and L5 levels. The TGFβ1, bFGF, IGF-1, NGF and Matrix metalloprotease III (MMP III) gene expressions of DNP materials were determined by polymerase chain reaction, Real-time polymerase chain reaction and western blotting techniques.Results: When the results of the two groups were compared by polymerase chain reaction, the expressions of TGFβ1, bFGF, IGF-1, NGF and MMP III was found lower in lumbar DNP group. Also the TGFβ1, bFGF, IGF-1, NGF, and Matrix metalloprotease III genes showed a decrease in gene expression levels when they were analyzed by Real-time polymerase chain reaction. Conclusion: These data showed that; decrease of the TGFβ1, bFGF, IGF-1, NGF and MMP III genes in the degenerated lumbar disc tissues, may related with the possibility of molecular background of the disease pathogenesis.
  • Küçük Resim
    Öğe
    Effects of epilepsy control following decompressive craniectomy on mortality and morbidity in epileptic patients with malignant MCA infarction
    (2020) Gezgin, Inan; Kafadar, Huseyin; Yucetas, Seyho Cem; Cakir, Tayfun
    Aim: The present study aims to investigate the effects of seizure or epilepsy formation on mortality and morbidity in epileptic patients after craniectomy.Material and Methods: The patients were divided into the following groups: Group 1, those who had no seizures, but were routinely treated with 3x100 mg of epanutin daily (n=6), Group 2, those who had at least one or multiple seizures and were initiated a second antiepileptic drug in addition to 3x100 mg of epanutin daily (n=13), and Group 3, those who had multiple seizures and who were sedated or narcotized in addition to being treated with 3x100 mg of epanutin daily (n=7). All patients underwent decompressive craniectomy within a maximum period of 48 hours and their characteristics such as age, gender, localization of infarct, hemiplegia, monoplegia, operation time, Glasgow coma and outcome scales were recorded. Results: According to the Glasgow Outcome Scale, 1 patient in Group 1, 8 patients in Group 2 and 6 patients in Group 3 died and there was a significant increase in patient losses in Group 2 and Group 3 compared to Group 1 (p0.05). 10 patients continued to live their lives with the support of home-care services and 2 patients with other forms of help. Conclusion: It was seen that there is a high incidence of seizure and epilepsy in MMCA infarcts after decompressive craniectomy and this significantly increased mortality or dysfunctional recovery if epilepsy could not be brought under control.
  • Küçük Resim
    Öğe
    What is the optimum time to decompressive surgery in the patients with malignant middle cerebral artery infarction?
    (2019) Yucetas, Seyho Cem; Ucler, Necati; Kafadar, Safiye; Cakir, Tayfun; Kilinc, Suleyman
    Aim: In the patients with malignant middle cerebral artery (MCA) infarctions, the mortality was as high as 70% with conservative treatment. Decompressive craniectomy (DC) was shown to decrease mortality especially in 48 hours. We aimed to investigate both the effect of decompression time and the size of craniectomy on the mortality in this patient group. Material and Methods: 45 adult patients underwent to DC due to malignant MCA infarction were evaluated in this study. The demographic and clinical features were recorded retrospectively. The patients were splitted into three groups: Group 1, DC in the first 24 hours; group 2, in 24-48th hours; group3, in 48-96th hours of the admission. The size of craniectomy was the same as the infarct (standard), or it was two centimeters larger than the size of infarct (larger). Results: Of all patients, 53.3% (n=24) was female; and mean age of the sample was 67.38±4.76. 66.7% (n=30) of the patients died due to malign MCA infarction. The size of craniectomy was larger in 26.7% (n=12), and was standard in the others. Mean time to surgery was 43.07±29.87 hours. Mortality rate was minimum in group 2 (p=0.01). The patients undergoing to larger craniectomy survived longer than the others, but the difference was non-significant (p=0.06). Conclusion: We suggested that not the approach of “surgery as soon as possible” but the surgery between 24-48th hours of the admission would be the optimal approach. This issue is especially important, because earlier or later interventions not only have a less benefit on the outcome but also may lead several unnecessary complications.