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    Acute renal injury due to rhabdomyolysis: A tertiary hospital experience
    (2021) Arac, Esref; Solmaz, Ihsan; Yuksel, Enver; Ekin, Nazim; Arac, Songul
    Aim: Rhabdomyolysis (RML) is a clinical and biochemical syndrome caused by acute necrosis of striated muscle fibers and the subsequent transportation of potentially toxic cellular contents into the systemic circulation. In this study, we present data from rhabdomyolysis patients that developed acute renal failure who were hospitalized and treated in our clinic in 2019. Materials and Methods: We reviewed all cases of RML treated in the tertiary hospital within a 12-month period, which was defined as serum creatinine kinase (CK) levels > five times the upper normal limit. The inclusion criteria were as follow: (a) being aged ≥ 18 years, (b) being treated for RML within the designated time period, (c) AKI development. The exclusion criteria are as follows: (a) being aged 5 time upper normal limit (UNL), 14 conformed to the inclusion criteria and were selected as subjects Results: A total of 14 patients were included in the study, 12 of which were male. The mean age of the patients was 48.1 (18–80). The etiologies were as follows: hypothyroidism, 3; prolonged exposure to sun, 2; electrolyte imbalance due to severe diarrhea, 1; viral upper respiratory tract infection (URTI), 3; intramuscular injection, 1; heavy exercise or falls.Conclusion: Rhabdomyolysis is an interdisciplinary clinical condition that can lead to life-threatening outcomes including AKI. Rapid diagnosis and treatment can be life-saving. AKI is a significant potential complication of RML and renal function should be evaluated irrespective of CK levels or the presence of myoglobinuria.
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    Histopathological evaluation of percutaneous renal biopsies: A single center experience
    (2021) Kaya, Seyhmus; Gunay, Emrah; Yuksel, Enver; Senol, Ayhan; Ay, Nurettin
    Aim: The aim of this study was to examine the indications, demographic features and histopathological diagnosis category of renal biopsies evaluated at the Pathology Laboratory of the University of Health Sciences Diyarbakır Gazi Yasargil Training and Research Hospital. Materials and Methods: The information of 190 patients who underwent percutaneous renal needle biopsy between July 2017 and February 2020 was obtained from the approved final pathology reports. Results: 190 biopsies were performed. 60% (n=114) and 40% (n=76) of the biopsies were native and transplant, respectively. 59.5% of the patients were male. Four of the patients were under 18 years. The mean ages of the native and transplant biopsy groupes were 37±14, and 34±14, respectively. Proteinuria was the most common biopsy indication (79.5%).Nonspecific changes were the most common diagnosis of the native biopsies. It was followed by focal segmental glomerulonephritis (FSGS), membranous glomerulonephritis (MGN), and IgA nephritis (IgAN). The most common secondary cause of glomerulonephritis was lupus nephritis. Acute cellular rejection was the most common diagnosis of the transplant renal biopsies. Conclusion: Proteinuria was identified as the most common indication for biopsy. In the present study, the primary glomerular disease was FSGS while the secondary was lupus nephritis. With electron microscopic examination, it might be possible to decrease the number of patients who cannot be definitively diagnosed histomorphologically