Yazar "Yuksel, Furkan" seçeneğine göre listele
Listeleniyor 1 - 14 / 14
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Cytotoxic and Genotoxic Effects of Nateglinide on A2780, LNCaP and Caco2 Cell Lines(Wiley, 2023) Oz, Samet; Yuksel, Furkan; Sekerci, Guldeniz; Tekin, Suat[Abstract Not Available]Öğe Effects of Meteorin-Like Protein on Pain in an Experimental Diabetes Model(Wiley, 2023) Yuksel, Furkan; Tekin, Suat; Ozcan, Mete; Sandal, Suleyman[Abstract Not Available]Öğe Evaluation of Coronary Flow Level with Mots-C in Patients with STEMI Undergoing Primary PCI(Arquivos Brasileiros Cardiologia, 2023) Cakmak, Tolga; Yasar, Erdogan; Cakmak, Esin; Tekin, Suat; Karakus, Yasin; Turkoglu, Caner; Yuksel, FurkanBackground: The protective effects of mitochondrial open reading frame of the 12S rRNA-c (MOTS-C) on cardiovascular diseases have been shown in numerous studies. However, there is little documentation of the relationship between MOTS-C and coronary blood flow in ST-segment elevation myocardial infarction (STEMI). Objective: We aimed to investigate the role of MOTS-C, which is known to have cytoprotective properties in the pathogenesis of the no-reflow phenomenon, by comparing the coronary flow rate and MOTS-C levels in patients with STEMI submitted to primary PCI. Methods: 52 patients with STEMI and 42 patients without stenosis >50% in the coronary arteries were included in the study. The STEMI group was divided into two groups according to post-PCI TIMI (Thrombolysis In Myocardial Infarction) flow grade:(i) No-reflow: grade 0, 1, and 2 and (ii) grade 3(angiographic success). A p value of <0.05 was considered significant. Results: MOTS-C levels were significantly lower in the STEMI group compared to the control group (91.9 +/- 8.9 pg/mL vs. 171.8 +/- 12.5 pg/mL, p<0.001). In addition, the Receiver Operating Characteristics (ROC) curve analysis indicated that serum MOTS-C levels had a diagnostic value in predicting no-reflow (Area Under the ROC curve [AUC]:0.95, 95% CI:0.856-0.993, p<0.001). A MOTS-C >= 84.15 pg/mL measured at admission was shown to have 95.3% sensitivity and 88.9% specificity in predicting no-reflow. Conclusion: MOTS-C is a strong and independent predictor of no-reflow and in-hospital MACE in patients with STEMI. It was also noted that low MOTS-C levels may be an important prognostic marker of and may have a role in the pathogenesis of STEMI.Öğe Investigation of anticancer effects of Meteorin like protein on different human cancer cell lines(2024) Sekerci, Guldeniz; Beytur, Leyla; Yuksel, Furkan; Tekin, SuatAim: Cancer is one of the biggest health problems threatening humanity, and the fight against cancer continues with different methods worldwide. Despite advances in cancer prevention and treatment, the low success rate and tumor recurrence make the discovery of new alternative agents important. Adipokines are among those known to be associated with cancer. The relationship of the peptide-structured Meteorin like protein (Metrnl), a member of the adipokine family, discovered in 2012, with cancer remains a mystery. This study was conducted to examine the cytotoxic effects of Metrnl on human ovarian, prostate, colon and breast cancer cell lines. Materials and Methods: In the study, ovarian (A2780), human prostate (LNCaP), colon (Caco-2) and breast cancer (MCF-7) cell lines were used. After the cells were incubated with 1, 5, 10, 50, 100 and 200 ng/mL Metrnl for 24 h, the cytotoxicity level was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT) assay method. determined. Comparisons between groups were made with the Kruskal Wallis H-Test. Results: Concentrations of Metrnl significantly reduced cell viability in A2780, LNCaP, Caco-2 and MCF-7 cell lines (p<0.05). Conclusion: These results show that Metrnl may have anticarcinogenic activity on A2780, LNCaP, Caco-2 and MCF-7 cells, but further studies are needed on this subject.Öğe Investigation of Cytotoxic and Genotoxic Properties of Hybrid Compounds Containing New Generation Amino Acid Structures(Wiley, 2023) Sekerci, Guldeniz; Yuksel, Furkan; Tekin, Suat; Caliskan, Eray; Biryan, Fatih; Koran, Kenan; Sandal, Suleyman[Abstract Not Available]Öğe Investigation of Lorentz field effects on wound healing: theoretical, computational, and experimental analysis(Iop Publishing Ltd, 2026) Gurcan, Aliye; Acikgoz, Merve; Tutuk, Rabia; Aydin, Elif Feyza; Yuksel, Furkan; Korkmaz, Engin; Tekin, CigdemObjective. This study introduces a novel non-invasive wound healing method that generates Lorentz fields (LFs) in the wound area using ultrasonic transducers under a static magnetic field, enabling localized stimulation without direct electrode contact. Approach. Theoretical derivations of the governing equations, supported by numerical simulations, demonstrate the feasibility and potential effectiveness of this technique. The model includes the two-dimensional geometry of the wound, skin layers, gel, a single-element ultrasonic probe, or a 16-element linear phased array (LPA) transducer. The pressure and velocity current density distributions in the wound area were analyzed under three different excitation configurations: (i) excitation using a single-element ultrasonic probe, (ii) beam steering of the LPA transducer at 5 degrees intervals between -30 degrees and +30 degrees at 13 different angles, and (iii) focusing of the LPA transducer at 0 degrees. In each configuration, distinct pressure distributions and velocity current density patterns were obtained in the wound region. In addition, in vivo animal experiments were conducted using the single-element ultrasonic probe to evaluate the biological effects of LF-based stimulation on wound healing. The study included four experimental groups: a static magnetic field (SMF) group, an ultrasound (US) group, a combined LF group, and a control group without any stimulation. Main results. In the single-element probe configuration, the simulated velocity current density reached approximately 4.51 mu Acm-2, corresponding to a pressure of 0.17 MPa. These values remained within the established safety limits while being sufficient to promote wound healing. For the LPA transducer, electronic beam steering enabled a uniform distribution of acoustic pressure and induced current density over a wider wound area. The pressure ranged between +/-(0.118-0.203) MPa, and the corresponding velocity current density varied between +/-(2.33-2.69) mu Acm-2. In the focusing configuration (0 degrees), the maximum pressure in the wound region reached 0.285 MPa, while the peak absolute velocity current density was 6.72 mu Acm-2, both remaining within safe limits. Animal experiments were conducted for 14 d, with each group receiving a 5 min daily treatment. The Lorentz-field group exhibited the fastest wound closure, followed by the US and magnetic-field groups, whereas the control group showed the least improvement. Significance. The proposed method offers an innovative and safe alternative for accelerating wound healing by combining US and SMFs to generate Lorentz-induced current densities in the wound, providing localized and non-invasive therapeutic stimulation.Öğe Investigation of the Effects of Agomelatine Administration on Apoptosis and Autophagy in Experimental Cerebral Ischemia/Reperfusion Modeled Rats(Wiley, 2025) Ozkaya, Semiha Nur; Tanbek, Kevser; Yuksel, Furkan; Tekin, Suat[No abstract available]Öğe Investigation of the Effects of Meteorin-Like Protein in a Model of Neuropathy Induced by Sciatic Nerve Injury(Wiley, 2023) Tekin, Suat; Yuksel, Furkan; Ozcan, Mete; Sandal, Suleyman[Abstract Not Available]Öğe Meteorin-Like Protein Reduces Oxidative Damage in Diabetic Mice(Wiley, 2023) Yuksel, Furkan; Tekin, Suat; Ozcan, Mete; Tekin, Cigdem[Abstract Not Available]Öğe Neuroprotective effect of transient receptor potential Vanilloid 1 agonist capsaicin in Alzheimer?s disease model induced with okadaic acid(Elsevier, 2023) Cakir, Murat; Yuksel, Furkan; Ozkut, Mahmud Mustafa; Durhan, Merve; Kaymak, Emin; Tekin, Suat; Cigremis, YilmazBackground: The presence of Transient Receptor Potential Vanilloid 1 (TRPV1) channels was detected in many regions of the human and rat brain, including the cortex and hippocampus. TRPV1 channels have functions such as the modulation of synaptic transmission and plasticity and the regulation of cognitive functions. Previous studies conducted with TRPV1 agonists and antagonists show that this channel is associated with the neuro-degenerative process. In the present study, the purpose was to investigate the effects of capsaicin, which is a TRPV1 agonist, and capsazepine, a TRPV1 antagonist, in the Alzheimer's Disease (AD) model that was induced by intracerebroventricular (ICV) administration of okadaic acid (OKA). Methods: The AD-like experimental model was created with bilateral ICV OKA injection. Intraperitoneal capsaicin and capsazepine injections were administered to the treatment groups for 13 days and histological and immu-nohistochemical examinations were performed from the cortex and hippocampal CA3 regions of the brain. The Morris Water Maze Test was used for spatial memory measurement.Results: ICV OKA administration increased the levels of caspase-3, phosphorylated-tau-(ser396), A beta, TNF-alpha, and IL1-beta, from the cortex and hippocampal CA3 regions of the brain and decreased the phosphorylated-Glycogen synthase kinase-3 beta-(ser9) levels. In addition, the OKA administration corrupted the spatial memory. The TRPV1 agonist capsaicin reversed the pathological changes induced by ICV OKA administration, but not the TRPV1 antagonist capsazepine.Conclusions: It was found in the study that the administration of the TRPV1 agonist capsaicin reduced neuro-degeneration, neuroinflammation, and deterioration in spatial memory in the AD model induced by OKA.Öğe Phosphazene Tripeptide Conjugates: Design, Synthesis, In Vitro Cytotoxicity and Genotoxicity, Molecular Interactions in Binding Pockets on Human Breast and Colon Cancer Cell Lines(Wiley-V C H Verlag Gmbh, 2025) Caliskan, Eray; Yuksel, Furkan; Capan, Irfan; Tekin, Suat; Bouzidi, Reda; Qaoud, Mohammed T.; Biryan, FatihThe biological activity of both cyclophosphazenes and peptides makes these compounds important for new studies in medicinal chemistry. For this purpose, five different phosphazene-peptide conjugates synthesized from dichlorocyclotriphosphazene and tyrosine-containing tripeptides. The synthesized compounds were evaluated for their in vitro cytotoxic activities against human breast (MCF-7) and colon (Caco-2) cancer cell lines using MTT assay. The derivatives induced cell death through DNA damage, with notable effects in Caco-2 cell lines. Specifically, DTVV, DTVG, and DTVA were cytotoxic at 50 and 100 mu M, while DTVP and DTVM were effective at 25, 50, and 100 mu M. DTVM outperformed Tamoxifen at 50 mu M in the MCF-7 cell line. DNA damage studies of the compounds were performed using the comet assay method, evaluating tail length, tail density, olive tail moment, head length, and head density parameters. The findings indicated that cell death occurred via a DNA damage mechanism. The molecular intricacies of DTVA, DTVG, DTVM, DTVP and DTVV within the VEGFR2 kinase domain (3VHE) and Cyclophilin_CeCYP16-Like Domain (2HQ6) binding pockets and various interactions, docking scores and potential activities of these derivatives were investigated. The differences in docking scores and interaction profiles highlight the potential efficacy and specificity of these compounds in targeting breast and colon cancer cells. These findings highlight the potential of phosphazene-peptide derivatives as therapeutic agents in cancer treatment.Öğe Synthesis and anticancer properties of novel hydrazone derivatives incorporating pyridine and isatin moieties(Wiley-V C H Verlag Gmbh, 2021) Zebbiche, Zineddine; Tekin, Suat; Kucukbay, Hasan; Yuksel, Furkan; Boumoud, BoudjemaaNine novel hydrazone derivatives (4a-i) incorporating pyridine and isatin moieties were synthesized through one-pot, four-component heterocyclic condensation reactions. The structures of all new compounds (2a-e, 3a, 3c-e, and 4a-e) were identified by H-1 nuclear magnetic resonance (NMR), C-13 NMR, and Fourier-transform infrared spectroscopic techniques and elemental analysis. Cell viability assays for the tested hydrazone derivatives were performed and the log IC50 values of the compounds were calculated after a 24-h treatment. All hydrazide derivatives tested showed a promising antitumor activity against A-2780 cells as compared with the standard drug docetaxel with a log IC50 value of 0.2200 mu M (p < .05). Seven of the examined compounds (4b-e, 4g-i) showed high cytotoxic activity against A-2780 cells as compared with the standard drug docetaxel. Whereas the log IC50 of docetaxel was 0.2200 mu M for A-2780 cells at 24 h, the IC50 values of these compounds were -0.4987, -0.4044, -0.8138, -0.3868, -0.6954, -0.4751, and 0.1809 mu M, respectively. Three of the compounds, 4b, 4d, and 4i, showed high cytotoxic activity against MCF-7 cells as compared with docetaxel (p < .05). Whereas the log IC50 of docetaxel was 0.2400 mu M for MCF-7 cells at 24 h, the log IC50 values of compounds 4b, 4d, and 4i were -0.1293, -0.1700, and 0.2459 mu M, respectively.Öğe The Effects of Meteorin-Like Protein on Diabetic Neuropathy: In Vivo and In Vitro Model Studies(Wiley, 2025) Yuksel, Furkan; Taslidere, Asli; Ozcan, Mete; Tekin, Cigdem; Tekin, SuatDiabetes is a disease characterized by insulin metabolism, and diabetic neuropathy (DN) develops as a result of prolonged hyperglycemia. Meteorin-like protein (Metrnl), which has been found to regulate insulin resistance in conducted studies, is thought to be therapeutic for type-2 diabetes. This study was conducted to investigate the efficacy of Metrnl on In Vivo and In Vitro diabetic neuropathy model. In study, 40 normoglycemic male Balb-C mice were divided into 4 groups (n = 10). Except for control, all groups received a single intraperitoneal (ip) injection of streptozotocin (STZ). After 72 h, blood glucose level was measured and animals above 250 mg/dL were considered diabetic. 14-day experiments were initiated 21 days after the onset of diabetes. Every day for 14 days, 0.9% isotonic sodium chloride was administered to DN group, and 2-4 mu g/kg/day ip Metrnl was administered to treatment groups, and nociceptive behavior tests were performed simultaneously. End of experiment, animals were decapitated, and pancreatic tissues were collected. Dorsal root ganglion (DRG) isolated from Wistar Albino rats aged 1-2 days were exposed to high glucose for 24 , and the effect of Metrnl on cell viability and cellular pathway it utilizes were determined. It was observed that Metrnl injection increased the pain threshold (p < 0.05), improved oxidative stress parameters (p < 0.05), and restored histopathological damage of the pancreas (p < 0.05) compared to the DN group. Furthermore, Metrnl was detected to increase cell viability by utilizing mitogen-activated protein kinase pathway in DRG (p < 0.05). These findings suggest that Metrnl has neuroprotective and analgesic efficacy and ameliorates oxidative damage and histopathologic status of pancreas.Öğe TRPV1 Agonist Capsaicin Reduces Neurodegeneration in Alzheimer's Disease Model Induced with Okadaic Acid(Wiley, 2023) Cakir, Murat; Yuksel, Furkan; Ozkut, Mahmud Mustafa; Tekin, Suat; Kaymak, Emin[Abstract Not Available]
