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    Crystallized phenol treatment is less effective in patients with recurrent pilonidal disease after surgery compared to patients with primary pilonidal disease
    (2020) Yuksel, Mehmet Eren
    Aim: Primary pilonidal disease can be treated with crystallized phenol with an overall cure rate of 80%. However, the effect of crystallized phenol in patients who had recurrence after pilonidal disease surgery has not been analyzed in the English medical literature in detail yet. The purpose of this study was to investigate the effect of crystallized phenol in recurrent pilonidal disease. Material and Methods: 28 male and 10 female patients who had recurrence after surgical intervention to treat pilonidal disease were evaluated. Twenty male and 8 female patients underwent excision and primary closure surgery, whereas 8 male patients and 2 female patients underwent modified Limberg flap surgery. All of these 38 patients were treated with one-time application of crystallized phenol.Results: The mean period for recurrence of patients treated with single application of crystallized phenol after primary excision and primary closure surgery was 45.85±11.82 days (range: 35-90 days) and it was 66.5±25.31 days (range: 40-120 days) after modified Limberg flap surgery. The follow-up period was 6 months. The cure rate in recurrent excision and primary closure group was 57.14%, whereas the cure rate in the recurrent modified Limberg flap group was 40%. Overall cure rate was 52.63%.Conclusion: As a result, crystallized phenol treatment was less effective in patients who had recurrence after pilonidal disease surgery in comparison to patients who were only treated with crystallized phenol without prior surgical intervention.
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    May quinacrine be considered for the treatment of patients with Covid-19?
    (2021) Tamer, Funda; Yuksel, Mehmet Eren
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    Pilonidal disease specimens of 905 patients revealed no malignancy, however we still insist on histopathological examination
    (2020) Yuksel, Mehmet Eren; Ordu, Melike
    Aim: Pilonidal disease presents with acute abscess, sinuses, pits and scarring in the sacrococcygeal region. Surgical intervention is one of the treatment options of pilonidal disease. However, it has been a matter of debate, whether histological analysis of surgically resected pilonidal disease specimens would be necessary. Material and Methods: Medical records of the patients with pilonidal disease who underwent either primary excision and closure or modified Limberg flap surgery were reviewed retrospectively. The results of the histopathological examination of the pilonidal disease specimens were evaluated.Results: This study included 905 patients (686 male and 219 female) with pilonidal disease who were treated with surgical intervention. The mean age of the patients was 23.96±7.5 years. All surgically excised pilonidal disease specimens of the patients were histopathologically evaluated in order to rule out malignancy. No malignancy was detected.Conclusion: We conducted a Pubmed search with the term “pilonidal” between January 2000 and March 2019. We identified 91 patients with malignant degeneration arising on pilonidal disease in the English medical literature. The most common pilonidal disease associated malignancy was squamous cell carcinoma. Even it is rare, malignancy may accompany pilonidal disease. Therefore, even we have not encountered any malignancy in 905 patients with pilonidal disease, we still insist on histopathological examination of all surgically resected pilonidal disease specimens in order to rule out malignancy.