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Öğe Early-married and sexually abused girls differ in their psychiatric outcomes(Pergamon-Elsevier Science Ltd, 2014) Soylu, Nusret; Ayaz, Muhammed; Yuksel, TugbaEarly marriage and sexual abuse are the two of the most frequent types of childhood abuse. Although early marriage is also a type of sexual abuse, it is associated with different physical, social, and mental outcomes than sexual abuse alone. The purpose of this study was to compare early-married girls and sexually abused girls who were referred for forensic evaluation in Turkey in terms of their sociodemographic characteristics, mental disorder rates, and mental symptom severity. We included 63 adolescent girls for whom a judicial report had been demanded and who were under 15 years old when they were married but were not yet 18 years old during the evaluation (15.51 +/- 0.78) and 72 sexually abused adolescent girls between 14 and 18 years old (15.80 +/- 1.10) in this study. Following a psychiatric evaluation, the study participants completed the Child Posttraumatic Stress Disorder Reaction Index (CPTS-RI) and the Brief Symptom Inventory (BSI). We used the Windows SPSS 16.0 software program to assess the results. At least one psychiatric disorder was determined in 44.4% of the early-married and 77.8% of the sexually abused cases (p < 0.001). A diagnosis of PTSD or ASD was observed in 11.1% of the early-married cases and in 54.2% of the sexually abused victims (p < 0.001). MDD was determined in 33.3% of the early-married cases and 56.9% of the sexually abused cases (p = 0.006). The CPTS-RI scores of the sexually abused victims were higher than those of the early-married cases (p < 0.001). All of the subscale scores of the BSI were higher in the sexually abused adolescents than in the early-married cases (p < 0.001). Although early marriage has severe physical, social and mental outcomes, it is not as severe as sexual abuse in terms of psychiatric disorder rates and the psychiatric symptom severity it causes. (C) 2014 Elsevier Ltd. All rights reserved.Öğe Heart rate variability as an indicator of autonomous nervous system activity in children withattention deficit hyperactivity disorder(Cumhurıyet unıv tıp fak psıkıyatrı anabılım dalı, cumhurıyet unıv tıp fak psıkıyatrı abd, sıvas, 58140, turkey, 2018) Yuksel, Tugba; Ozcan, OzlemObjective: The aim of the present study was to evaluate heart rate variability (HRV) in children newly diagnosed as attention-deficit/hyperactivity disorder (ADHD). Methods: A total of 51 children with new ADHD diagnosis who were not received any treatment formed the study group and 51 age and sex-matched healthy children were enrolled as the control group. 24-hour heart rate (HR) recordings were performed with rhythm Hotter monitoring and HRV parameters indicating autonomous nervous system (ANS) functions were evaluated. Children in ADHD group were further divided into two groups as 'severe' and 'mild' ADHD according to Clinical Global lmpressions-ADHD-Severity scale. Results: HRV parameters were comparable between ADHD and control groups. Whereas, percentage of consecutive NN intervals over 50 msn (pNN50) and minimum Spectral Power per hour (minSPH) values were lower; while, maximum 1-hour heart rate Hotter (maxHRH) and mean heart rate (HR) values were higher in severe ADHD group than those of control group. Conclusion: These results support that as the severity of ADHD increases, ANS dysfunction becomes more overt. Further large scale, multi-centered, randomized-controlled clinical trials are needed to clarify possible role of ANS dysfunction in ADHD etiopathogenesis.Öğe No evidence of androgenic neurosteroid involvement in pediatric OCD(Elsevier Science Bv, 2015) Erbay, Lale Gonenir; Ozcan, Ozlem Ozel; Kartalci, Sukru; Yuksel, Tugba; Kutuk, Meryem OzlemCertain androgenic neurosteroids have been shown to have a relationship with anxiety disorders in adults. Demonstrating these changes in pediatric patients as well is important in terms of elucidating the etiology of these disorders. The aim of this study was to investigate the testosterone, DHEA-S and cortisol levels in pediatric obsessive-compulsive disorder (OCD) patients. A total of 39 pediatric OCD patients aged 7-16 years and 34 healthy children of similar age and gender were included in this study. Serum total testosterone, DHEA-S and cortisol levels were measured by using the ELISA method and their relationship with clinical data was investigated. No statistically significant difference was found between the patient and control groups in terms of testosterone, DHEA-A and cortisol levels in the analyses performed (p=0.175, p=0.642. p=0.842. respectively). The results of this first study have revealed that testosterone, DHEA-S and cortisol levels in pediatric OCD patients are not different than in the controls. However, the fact that these neurosteroid levels have been found to differ between adult patients and controls previously indicates that neurosteroid changes may be a finding that appears during the course of anxiety disorders. (C) 2015 Elsevier Inc. All rights reserved.Öğe Relationship between anxiety, anxiety sensitivity and conduct disorder symptoms in children and adolescents with attention-deficit/hyperactivity disorder (ADHD)(Springer, 2013) Bilgic, Ayhan; Turkoglu, Serhat; Ozcan, Ozlem; Tufan, Ali Evren; Yilmaz, Savas; Yuksel, TugbaAttention-deficit hyperactivity disorder (ADHD) is often comorbid with anxiety disorders and previous studies observed that anxiety could have an impact on the clinical course of ADHD and comorbid disruptive behavioral disorders (conduct disorders and oppositional-defiant disorders). Anxiety sensitivity (AS) is a different concept from anxiety per se and it is believed to represent the constitutionally based sensitivity of individuals to anxiety and anxiety symptoms. We aimed to assess the associations between anxiety, AS and symptoms of disruptive behavioral disorders (DBD) in a clinical sample of children and adolescents with ADHD. The sample consisted of 274 treatment naive children with ADHD aged 8-17 years. The severity of ADHD symptoms and comorbid DBD were assessed via parent rated Turgay DSM-IV-Based Child and Adolescent Behavioral Disorders Screening and Rating Scale (T-DSM-IV-S), Conners' Parent Rating Scale (CPRS), and Conners' Teacher Rating Scale (CTRS). AS and severity of anxiety symptoms of children were evaluated by self-report inventories. The association between anxiety, AS, and DBD was evaluated using structural equation modeling. Analyses revealed that AS social subscale scores negatively predicted symptoms of conduct disorder (CD) reported in T-DSM-IV-S. On the other hand, CD symptoms positively predicted severity of anxiety. No direct relationships were detected between anxiety, AS and oppositional-defiant behavior scores in any scales. These results may suggest a protective effect of AS social area on the development of conduct disorder in the presence of a diagnosis of ADHD, while the presence of symptoms of CD may be a vulnerability factor for the development of anxiety symptoms in children and adolescents with ADHD.Öğe Stuttering after testosterone administration: A case report(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2012) Kartalci, Sukru; Erbay, Lale Gonenir; Ozcan, Ozlem Ozel; Yuksel, Tugba; Unal, SuheylaStuttering is defined as a disturbance in the normal fluency and time patterning of speech. There are two kinds of stuttering: developmental and acquired. However, the etiology of stuttering is controversial; it is well known that the sex of the patient clearly influences stuttering. There is a higher incidence of stuttering in males than in females. Furthermore, although stuttering is common in children, it often resolves before adulthood in especially females. Environmental influences, such as stressful social situations which are associated with elevated androgen secretion, may also contribute to the persistence of stuttering. Considering all this together, one of the reasons underlying this gender difference in stuttering may be sex hormones. Acquired stuttering can occur at all ages and can be caused by pharmacological agents. Testosterone is an androgenic drug that has diverse side-effects, but an extensive review of the literature has failed to show stuttering as one of the complications. We present a case in which testosterone was implicated as a potential cause of stuttering. (Anatolian Journal of Psychiatry 2012;13:82-84)
