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Öğe Adrenomedullin affects hypoxia inducible factor 1 alpha in rats under hypoxic conditions(Wiley-Blackwell, 2016) Culum, A. A.; Gurses, C.; Yurekli, M.[Abstract Not Available]Öğe Adrenomedullin: Possible predictor of insulin resistance in women with polycystic ovary syndrome(Springer, 2012) Sahin, I.; Celik, O.; Celik, N.; Keskin, L.; Dogru, A.; Dogru, I.; Yurekli, M.The aim of the study was to investigate adrenomedullin (ADM) levels and its relation with insulin resistance in women with polycystic ovary syndrome (PCOS). Twenty-nine women with PCOS and 29 age- and body mass index (BMI)-matched control subjects were included in the study. PCOS was defined according to criteria by the Rotterdam European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM)-sponsored PCOS consensus workshop group. A full clinical and biochemical examination including basal hormones and metabolic profile was performed. Insulin resistance was calculated by using the homeostasis model assessment of insulin resistance index (HOMA-IR). Plasma ADM levels were measured by high performance liquid chromatographic (HPLC) method. Plasma ADM, fasting insulin levels and HOMA-IR were significantly higher in patients with PCOS than the control group. ADM levels were positively correlated with insulin levels and HOMA-IR index. The best cut-off value of ADM levels to identify the presence of insulin resistance (HOMA-IR >= 2.7) was 30.44 ng/ml. Calculated odds ratio of insulin resistance by using logistic regression analysis, as predicted by ADM, was 0.15 (95% confidence interval, 0.037-0.628; p=0.009). In multiple regression analysis, ADM level was an independent predictor of HOMA-IR index. Our finding indicated that ADM levels increased in women with PCOS in accordance with HOMA-IR. ADM could be a significant independent determinant of insulin resistance in women with PCOS. (J. Endocrinol. Invest. 35: 553-556, 2012) (C) 2012, Editrice KurtisÖğe Antioxidant enzymes activities in rat kidney after cold stress exposure(Wiley-Blackwell Publishing, Inc, 2009) Yildirim, N. Cikcikoglu; Yurekli, M.; Matpan, F.; Yildirim, N.[Abstract Not Available]Öğe The effect of adrenomedullin and cold stress on interleukin-6 levels in some rat tissues(Wiley, 2010) Yildirim, N. C.; Yurekli, M.P>Stress known to stimulate sympathetic activity, as well as the hypothalamic-pituitary-adrenal axis (HPA), produces a significant increase in adrenomedullin (AdM) levels, suggesting a regulatory or protective role for AdM in countering HPA activation that follows a variety of stressors. Stressors can modulate the secretion of proinflammatory cytokines. Interleukin (IL)-6 is a potent activator of the HPA and appears to play a pathogenic role in conditions related to stress. In the present study, we investigated the administration of AdM on IL-6 levels in cold exposed rats. Male Wistar rats were divided into four groups as control, adrenomedullin treatment, cold stress and cold stress+adrenomedullin-treated groups. In the adrenomedullin-treated group, animals received intraperitoneal (i.p.) injection of adrenomedullin (2000 ng/kg body weight) once a day for a week. For the cold stress exposure the rats were kept in separate cages at 10 degrees C for a week. Control group rats were kept in laboratory conditions. The concentration of IL-6 was determined using an enzyme-linked immunosorbent assay (ELISA) kit. When compared to control, IL-6 levels increased significantly in the cold stress- and adrenomedullin-treated groups (P < 0 center dot 05). Administration of AdM in addition to cold stress decreased IL-6 levels in lung and liver, but increased in brain and heart when compared to control (P < 0 center dot 05). The results suggest that cold stress may induce increase of rat proinflammatory cytokine IL-6 and adrenomedullin may play a regulatory or protective role for cold stress.Öğe The effect of cold stress on adrenomedullin levels in some rat tissues(Blackwell Publishing, 2006) Yildirim, N. Cicikoglu; Yurekli, M.[Abstract Not Available]Öğe The effects of adrenomedullin and methyl-adrenomedullin treatments on TNF-alpha levels in some rat tissues(Blackwell Publishing, 2008) Yildirim, N. Cikcikoglu; Yurekli, M.; Yildirim, M.; Matpan, F.[Abstract Not Available]Öğe STIMULATED SUPEROXIDE DISMUTASE (SOD) ACTIVITY AND ENHANCED NITRIC OXIDE (NO) IN BEAN PLANT: THE EFFECT OF CADMIUM(Springer Heidelberg, 2004) Yurekli, F.; Porgali, Z. B.; Dogru, A.; Dogru, M., I; Yurekli, M.[Abstract Not Available]
