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    A molecularly imprinted cotton fabric for rapid, selective and sensitive determination of carbendazim in orange juice
    (Academic Press Inc Elsevier Science, 2024) Zengin, Adem; Toptas, Yeliz; Bilici, Mustafa; Gursoy, Tulay
    Carbendazim is a type of benzimidazole fungicide commonly used to protect agricultural crops. It has high chemical stability and a long degradation half-life, which increases the potential for environmental accumulation. Herein, carbendazim-imprinted cotton fabric (MIPCF) was fabricated for the selective and sensitive detection of carbendazim in orange juice samples using spectrofluorimetry. The imprinted cotton fabrics were characterized using a variety of surface characterization techniques, and the results revealed the grafting of a polymer layer onto the cotton fabric. Furthermore, the MIPCF had a high adsorption capacity of 96.9 mg/g and an imprinting factor of 4.36. Importantly, MIPCF demonstrated satisfactory regeneration capability, enduring up to ten regeneration cycles without significantly reducing its initial adsorption capacity. The proposed method had excellent linearity with a correlation coefficient of 0.999 and a limit of detection of 1.12 mu g/L for carbendazim in orange juice samples. The proposed method exhibited acceptable recovery ranges (99.2-100 %) accompanied by lower inter-day and intra-day precisions. It is inferred that the proposed method offers a promising alternative for quantifying fungicides compared to conventional spectroscopic or chromatographic techniques.
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    A molecularly imprinted whatman paper for clinical detection of propranolol
    (Elsevier Science Sa, 2020) Akbulut, Yeliz; Zengin, Adem
    Determination of drug concentration in body fluids is important issue for clinical studies to arrange treatment of patients. In the present study, we concentrated on the preparation of propranolol-imprinted poly (N-acryloyl-L-phenylalanine) film on a paper surface for spectrophotometric detection of propranolol in human plasma samples. The surface characterization of the imprinted surface was carried out by attenuated total reflectancefourier transform spectroscopy, x-ray photoelectron spectroscopy, scanning electron microscopy and water contact angle measurements. Rebinding isotherms and kinetics were also investigated and maximum adsorption capacity of the imprinted paper surface was found to be 64.3 mg/g with high imprinting factor (4.20). Moreover, the results for selectivity and regeneration ability of the imprinted paper indicated that propranolol selectively interacted with the imprinted paper and had satisfactory reuse without changing its adsorption capacity. Under optimized conditions, the imprinted paper surface had a limit of detection of 0.3 mu g/mL with lower intraday and interday precisions for determination of propranolol. The proposed method was successfully applied to determine propranolol in plasma samples where it showed recoveries ranging from 97.0%-99.5%. The method was also compared with traditional ELISA method and the results showed that the proposed method is sensitive and selective. It is believed that the prepared paper-based molecularly imprinted polymers can be good alternatives to traditional drug assays in clinical practice.