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  • Küçük Resim
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    Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?
    (2020) cekici, Yusuf; Sincer, Isa; Kaplangoray, Mustafa; Yilmaz, Mucahid; Yildirim, Arafat
    Aim: Several studies have found a correlation between coronary slow flow (CSF) and low serum high-density lipoprotein cholesterol (HDL-C) levels or high serum uric acid levels. The present study aimed to evaluate whether serum uric acid to HDL-C ratio predicts CSF.Material and Methods: The experimental (CSF) group included 91 patients (40 females, 51 males, mean age: 52±9) who had angiographically normal coronary arteries but had slow flow in one or more coronary arteries. The control group included 96 patients (57 females, 39 males, mean age: 50±9) with normal coronary anatomy and without slow flow. The uric acid to HDL-C ratio was calculated for the two groups and compared.Results: The HDL-C levels of the CSF group (37±8 mg/dL) were significantly lower compared to the controls (49±10 mg/dL, p0.001), whereas serum uric acid levels (5.33±0.97 mg/dL) and uric acid to HDL-C ratio (0.14±0.03) of the CSF group were significantly higher compared to the controls (4.37±0.88 mg/dL and 0.09±0.02, p0.001 and p4.64 mg/dL uric acid and >0.119 % uric acid to HDL-C ratio had a sensitivity of 81% and 85% and specificity of 76% and 80% for determination of CSF, respectively (AUC=0.850, 95% CI: 0.792 - 0.908 and AUC=0.890, 95% CI: 0.841 - 0.940,respectively).Spearman's correlation test has been performed and a significant positive correlation has been detected between the uric acid to HDL-C ratio and the mean thrombolysis in myocardial infarction (TIMI) frame count (r=0.62, p0.001).Conclusion: In this study, higher uric acid to HDL-C ratio values of the CSF group was found compared to the control group. Furthermore, uric acid to HDL-C ratio performed better than serum uric acid levels in predicting CSF.
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    Evaluation of Tpe-interval and Tpe/QT, Tpe/QTc ratios in patients with premature ovarian failure
    (2019) cekici, Yusuf; Kilic, Salih; Saracoglu, Erhan; Ovayolu, Ali; Yilmaz, Mucahid; Duzen, Veysel Irfan
    Aim: Ventricular repolarization were evaluated in patients who had POF by using novel electrocardiographic parameters including Tpe-interval and Tpe/QT and Tpe/QTc ratios. A few studies have investigated the association between premature ovarian failure (POF) and cardiovascular diseases. However, none have examined ventricular repolarization in this respect.Materials and Methods: This cross-sectional study included 60 female patients with POF (mean 32.6±4.7 years) and 54 control healthy female subjects (mean 30.9±4.6 years).All electrocardiogram (ECG) measurements were performed by a cardiologist using a computer, and the Tpe-interval, Tpe/QT, and Tpe/QTc were compared between groups.Results: There were no significant differences between groups in terms of baseline characteristics and laboratory parameters. The Tpe-interval, Tpe/QT, and Tpe/QTc were significantly prolonged in POF group than control subjects (p0.001 for all). There was a strong and positive correlation between the serum follicle-stimulating hormone (FSH) level and Tpe-interval (r=0.681; p0.001) and Tpe/QTc (r= 0.636; p0.001). Furthermore, high and negative correlation was found between serum estradiol and Tpe-interval (r=-0.531; p0.001) and Tpe/QTc (r=-0.510). Multivariate linear regression analysis showed that that the FSH and estradiol level were independent predictors of both the Tpe-interval (B=0.541 and p0.001, B=-0.202 and p0.001, respectively) and Tpe/QTc (B=0.442 and p0.001, B= -0.239 and p0.001, respectively).Conclusion: It was concluded in the study that ECG parameters of ventricular repolarization, namely, Tpe-interval, Tpe/QT, and Tpe/QTc were significantly prolonged in patients that had POF.
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    Predictors of multivessel involvement in patients under 40 years of age receiving primary PTCA for STEMI
    (2019) Duzen, Irfan Veysel; cekici, Yusuf
    Aim: The angiographic features of myocardial infarction in young patients and the factors affecting these features differ from those in elderly patients and have not been fully established. The aim of this study was to investigate the factors involved in the development of multivessel disease in patients aged 40 years or younger with ST-segment elevation myocardial infarction (STEMI).Material and Methods: A total of 148 patients aged 40 years or younger who underwent primary percutaneoustransluminal coronary angioplasty for STEMI were included in the study. The demographic features, angiographic features, biochemical data and risk factors of the patients were reviewed retrospectively. Results: Assessment of the risk factors showed that 91.2% of the patients were male, 73% were smokers, 56.8% were hyperlipidemic, 36.1% were hypertensive and 23.1% had diabetes mellitus. A positive family history was present in 31.1% of the patients. Hyperlipidemia was significantly more common (p=0.008) and the hemoglobin values were significantly lower (p0.001) in the patients with multivessel disease than those with single-vessel disease. Anemia was also significantly more prevalent in the patients with multivessel disease (p0.001).A multivariate regression analysis showed that anemia was associated with a 21.740-fold increase(95% CI: 2.921-161.817; p=0.003)in the likelihood of developing multivessel disease, irrespective of other risk factors, while hyperlipidemia was associated with a 3.742-fold increase (95% CI: 1.104-12.679; p=0.034) and male sex was associated with a 9.390-fold increase (95% CI: 1.019-86.570) (p=0.048).Conclusion: Anemia, hyperlipidemia and male sex are associated with multivessel disease in STEMI patients aged 40 years or younger.Keywords: Anemia;hyperlipidemia; multivessel; young myocardial infarction.