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Öğe Acute-onset axonal neuropathy following infection in children with biallelic RCC1 variants: a case series(Elsevier Science Inc, 2025) Harkness, J. Robert; Mcdermott, John H.; Marsden, Shea; Jamieson, Peter; Metcalfe, Kay A.; Khan, Naz; Macken, William L.Background The reasons why some individuals have severe neuropathy following an infection are not known. Through the agnostic screening of children with acute axonal neuropathy after an infection, we identified several families with biallelic variants in RCC1. We aimed to describe the clinical phenotype of these patients, and the molecular and cellular pathology associated with the genetic variants identified in these families. Methods For this case series, we identified children affected by a severe, acute-onset axonal neuropathy following infection through an international research consortium of paediatric neurologists and clinical geneticists from nine countries (Canada, Cyprus, Czechia, Germany, Iran, Saudi Arabia, Slovakia, T & uuml;rkiye, and the UK). Clinical assessments included nerve conduction studies and neuroimaging. We did exome or genome sequencing in DNA samples from all patients. We characterised the proteins encoded by the genetic variants by use of thermal stability and enzymatic assays, using recombinantly expressed proteins. We assessed cellular protein transport under heat or oxidative stress by use of immunofluorescence in primary fibroblasts, obtained from patients. We generated a humanised Drosophila knock-in model to assess the effects of stress on the in vivo function of RCC1. Findings Between Nov 2, 2011, and July 10, 2024, we identified 24 individuals from 12 families who had severe, acute-onset axonal neuropathy following infection (13 female and 11 male patients, with a mean age at diagnosis of 1 year 10 months [SD 227]). Eight biallelic missense variants in RCC1 were identified in affected individuals with autosomal recessive inheritance. Patients had variable phenotypes, ranging from rapidly progressive fatal axonal neuropathy to mild motor neuropathy with impaired walking. Neurological presentation was often secondary to an infection, resulting in initial misdiagnoses of Guillain-Barr & eacute; syndrome in several patients. 15 children had disease recurrence. The disease was fatal in 15 patients. The RCC1 variants in these patients code for proteins that alter GDP-to-GTP exchange activity and have reduced thermal stability in vitro. In primary fibroblasts, heat shock or oxidative stress revealed defects in Ran nuclear localisation and impaired nucleocytoplasmic transport. A Drosophila model of the disease revealed a fatal intolerance to oxidative stress. Interpretation We describe an autosomal recessive, acute-onset paediatric axonal neuropathy, seemingly triggered by infection, that affects individuals with biallelic RCC1 variants. In these children, the disease can mimic Guillain-Barr & eacute; syndrome. The pathological mechanisms underlying this novel axonal neuropathy might overlap with those of amyotrophic lateral sclerosis. Cellular studies indicate that RCC1 variants affect nucleocytoplasmic transport, which is crucial for healthy axonal function. Future studies should be directed at pre-symptomatic treatment by exploring ways to maintain nucleocytoplasmic transport. Copyright (c) 2025 Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Öğe Relationship of Cryptocurrency Trading to Quality of Life, Sleep and Stress Levels in Academics(Int Ctr Mental Health Policy & Economics-Icmpe, 2024) Ucar, Mehmet; Yildiz, Metin; Ciftci, Necmettin; Aylaz, RukuyeBackground: Cryptocurrency trading has become popular with a large section of society, and the number of investors is increasing daily. It is critical to address the health impacts of cryptocurrency trading. Of particular importance is the issue of how such trading affects mental health. Research should be conducted on this topic, and where necessary, national governments should develop policies to combat these effects. Aims: This study was conducted to examine the relationship of cryptocurrency trading to quality of life, sleep, and stress levels in academics. Method: This descriptive and cross-sectional study was conducted with 437 academics working at a state university in Turkey. A Personal Information Form, the SF-12 Quality of Life Scale, the Scopa Sleep Scale, and the Perceived Stress Scale were used to collect data. These data were analyzed using SPSS 25.0 and G*Power 3.1 programs. Results: The data obtained in this study were analyzed using SPSS program (SPSS-25). The effect size and r-effect size were calculated with Cohen's d value. It was found that the mean scores for the SF- 12 Quality of Life Scale were statistically lower in academics who traded cryptocurrency than in those who did not. The results showed that the mean scores for the Scopa Sleep Scale and Perceived Stress Scale were statistically higher in academics who traded cryptocurrency than in those who did not (p<0.05). Discussion: The academics who traded cryptocurrency had more negative health outcomes when compared to those who did not. Social awareness should be raised on the negative effects of cryptocurrency trading. A limitation of the study is that only data obtained from the statements of the participants were included in the study. The study may have some generalizability to other academics, but has less generalizability to populations other than academics. Implications for Health Care Provision and Use: Cryptocurrency trading is a significant public health problem. Although cryptocurrency trading has been found to profoundly affect mental health (sleep, stress, and quality of life), the current policies that address these problems are generally inadequate in terms of implementing and sustaining mental healthcare systems. The limitations of these health policies prevent many individuals in society from receiving high quality services. Implications for Health Policies: Health systems alone cannot solve the systemic problems that lead to the population's dependence of mental health services and institutions. In order to solve this basic problem, it may be necessary for governments to increase individuals' basic incomes and develop specific mental health policies for people engaged in cryptocurrency trading. Implications for Further Research: Future studies should examine expert perspectives on mental health services in different contexts (e.g., behavioral addiction services), collect targeted feedback, and explore issues such as strategic planning and funding stability. Effective decisions should be made regarding the implementation and maintenance of treatment for behavioral addictions.Öğe The influence of IQ, emotional and spiritual perceptions on sports participation in an effort to improve physical health(Univ Murcia, 2024) Gemaini, Andri; Kiram, Yanuar; Komaini, Anton; Eken, Ozgur; Jalius, Hardzikrillah; Sepdanius, Endang; Rifki, Muhamad SazeliThis study aimed to determine the influence of intellectual intelligence (IQ), emotional, and spiritual perceptions on sports participation to improve physical health. It employed a quantitative research design using a survey method, with questionnaires distributed to participants. A total of 100 respondents, comprising both men and women who were government employees, took part in the study. Data collection was carried out through questionnaires distributed via Google Forms and documentation. Data analysis was conducted using the Partial Least Squares (PLS) method with SmartPLS software version 3. The results of this research indicated that emotions had a positive and statistically significant effect on IQ (p < 0.05), a negative and statistically insignificant effect on perceptions of physical health (p > 0.05), and a positive and statistically significant effect on spirituality (p < 0.05). IQ had a negative and statistically insignificant effect on perceived physical health (p > 0.05). In contrast, spirituality had a positive and statistically significant effect on perceptions of physical health (p < 0.05). This study suggested that for sports participants aiming to enhance their health through physical activity, it was beneficial to incorporate emotional intelligence, IQ, and spirituality. Consequently, the selection of sports activities should consider these factors (emotions, IQ, and spirituality) to maximize their positive effects.Öğe Living Liver Donor Paired Exchange: Can Anaesthesia Management Challenge?(Galenos Publ House, 2025) Erdogan, Mehmet Ali; Ucar, Muharrem; Colak, Yusuf Ziya; Demiroz, Duygu; Ozdes, Oya Olcay[No abstract available]Öğe Fear of Death and Sleep Quality in the Aftermath of an Earthquake(Slack Inc, 2025) Aktura, Seher Cevik; Celik, Hanife; Saritas, Seyhan Citlik; Ozden, GurkanPURPOSE: To examine fear of death and disruption in sleep patterns in individuals who have experienced an earthquake. METHOD: A descriptive and relationship-oriented study was performed with 322 individuals who experienced the February 6, 2023, earthquake in Turkey. Data were collected between February 20 and May 15, 2023. A personal information form, the Pittsburgh Sleep Quality Index (PSQI), and Death Anxiety Scale (DAS) were used for data collection. RESULTS: Participants'mean DAS score was 7.96 (SD = 1.05), and mean PSQI score was 8.74 (SD = 4.06). Statistically significant relationships were found between sex, marital status, and mean DAS score, and these variables accounted for 11.7% of the total variance. Similarly, statistically significant relationships were found among economic status, relationship to person trapped under the rubble, financial loss from the earthquake, and mean PSQI score, accounting for 11.3% of the total variance. Women and married people had greater fear of death, and those with good economic status, whose family members were buried under rubble, and who experienced financial loss as a result of the earthquake had lower sleep quality. CONCLUSION:The earthquake led to moderate fear of death and poor sleep quality among participants. Findings highlight the need for targeted support for vulnerable groups following disasters. [Journal ofPsychosocial Nursing and Mental Health Services, 63(2), 45-54.]Öğe Assessment of the Antifungal Effect of Biotechnological Product-A New Vegan Agent Microbial Chondroitin Sulfate Against Predominant Candida Strains(Jihad Daneshgahi, 2024) Erenler, Ayse Sebnem; Unver, Tuba; Melekoglu, RaufMicrobial Chondroitin Sulfate (CS), possesses biocompatible, antiallergic, and non-toxic properties due to its polyanionic structure hold potential as an antifungal agent. This study investigated the effectiveness of microbial CS generated from recombinant Escherichia coli C2987 by biotechnological techniques as an antifungal product for treating Candida infections. Chondroitin biosynthesis was conducted utilizing a recombinant non-pathogenic E. coli, generated through the transformation of plasmid pETM6-PACF-vgb, which carries genes (kfoA, kfoC, and kfoF) responsible for chondroitin synthesis, along with the Vitreoscilla hemoglobin gene (vgb). The broth microdilution and agar dilution assays were employed to assess the antifungal activity of microbial CS and commercial CS against predominant Candida strains comparatively. The inhibitory effect of microbial CS against Candida albicans, Candida tropicalis, Candida parapsilosis, , and Candida krusei was greater than that of commercial CS. This study demonstrates the antifungal activity of microbial CS, a pharmacological agent produced from a recombinant source (vegan-halal). Microbial CS can be a potential supportive treatment not only for vaginal candidiasis but also for other Candida infections that may cause skin and mucosal infections, with its supportive effect on connective tissues and its therapeutic-preventive effect on possible Candida infections.Öğe Tribological properties of the multilayer thin films deposited on the free-form shaped Ti13Nb13Zr alloy(Malaysian Tribology Soc-Mytribos, 2024) Aslan, Ali Kemal; Bahce, ErkanSurface coating processes are carried out to increase the wear and corrosion resistance of products with free-form surfaces used in the biomedical field. In this study, Ti/TiN/TiC/TiCN/TaN multilayer thin films were deposited on the surface of Ti13Nb13Zr alloy samples with different radii of curvature using the closed-field unbalanced magnetron sputtering technique. The wear and adhesion properties of thin films were examined with a specially developed wear test setup, in a simulated body fluid environment and an ultra-high molecular weight polyethylene (UHMWPE) counterpart was used. Scanning electron microscope and X-ray diffraction measurements were used to study the morphology and microstructure of the thin films before and after wear experiments. The delamination amounts of the coatings on the sample surfaces after the wear test were measured and this value was calculated as 8.73%, 12.16%, and 16.89% for the R14, R18, and R22 samples, respectively. As a result of these findings, it was determined that the wear resistance of the coatings decreased as the radius of the curvature increased. The wear amounts of the UHMWPE components are found as 15.45, 6.75, 8.15, 15.45, 6.75, and 8.15 mg for P0, P14, P18, and P22 samples, respectively.Öğe Dosimetric analysis of SIB whole brain radiotherapy planning: Comparison of coplanar VMAT and tomotherapy techniques(Wiley, 2025) Pepele, Eda Kaya; Temelli, OztunBackground Radiotherapy techniques have advanced significantly over the past few decades. Whole-brain radiotherapy combined with a simultaneous integrated boost (WBRT+SIB) is increasingly used to treat limited brain metastases. Purpose To retrospectively compare helical tomotherapy and coplanar volumetric modulated arc therapy (VMAT) for WBRT with a SIB-WBRT in patients with multiple brain metastases. Additionally, it emphasizes the importance of selecting appropriate evaluation indices when comparing SIB plans. Materials and methods Fifteen patients with 2- 3 metastatic lesions were retrospectively analyzed in this study. Treatment planning was performed using TomoHD and eclipse planning systems for tomotherapy and VMAT, respectively. Dose-volume histograms were used to assess the doses delivered to the target volumes and organs at risk (OARs). Quantitative metrics, including the homogeneity index (HI), conformity index (CI), and plan quality index (PQI), were used for the evaluation. Results Tomotherapy yielded significantly higher D98% values for both the planning target volume (PTV) WB and PTV_met compared with VMAT (p < 0.05). It also provided lower D-max and D-mean values for the lenses and eyes (p < 0.001 and p < 0.02, respectively). Tomotherapy was superior in terms of PTV whole-brain CI and PTV_met HI and CI (p < 0.05). However, no significant difference was observed in the PQI values between the techniques (p > 0.05). Conclusion Both tomotherapy and VMAT achieved acceptable target volumes and OAR doses in SIB applications. Tomotherapy showed advantages in terms of dose conformity and critical organ sparing. Moreover, this study highlights the impact of selecting appropriate evaluation indices on interpreting plan quality, particularly for complex treatment approaches such as SIB.Öğe Bio-Inspired Graded and Uniform Cylindrical Lattices Fabricated by Material Extrusion 3D Printing: An Experimental and Numerical Investigation(Wiley, 2025) Oymak, Mehmet Akif; Bahce, Erkan; Singh, GurminderThe main requirements of the biomedical and aerospace industries are new and innovative lightweight materials. Bio-inspired structures, which are inspired by various biological designs, have demonstrated notable advancements over traditional lightweight structures. In this study, bioinspired uniform and graded cylindrical triply periodic minimal surface (TPMS) and strut-based lattice structures were studied for their mechanical qualities and energy absorption capacities fabricated by material extrusion 3D printing using PLA material. It was found that the cylindrical TPMS diamond lattice achieved maximum stress of 78.5 MPa and absorbed 19.14 MJ/m3 of energy, outperforming strut-based designs with a 48% higher energy absorption than cylindrical BCC lattice structure. Graded designs further improve energy absorption through a better stress distribution. The findings validated the Gibson-Ashby model, highlighting the enhanced load distribution and stress transfer in the strut-based and TPMS diamond structures. The finite element (FE) model results closely matched the experimental data, confirming its predictive reliability with a maximum error of energy absorption of 7.7%, elastic modulus of 6.9%, and plateau stress of 4.7%. These insights underscore the superior energy absorption and mechanical stability of cylindrical TPMS diamond lattices, indicating their potential for satisfying stringent industrial and technical performance requirements. The novelty of these designs lies in their bioinspired structures and significant enhancements in mechanical performance and energy absorption. Future research should build on these results to design efficient materials tailored to specific needs using FE models to optimize development processes before experimental testing.Öğe Imidazol-2-Ylidene-Silver(I) Complexes Bearing 4-Acetylphenyl Side Arm: Design, Synthesis, Characterization, Crystal Structure, and Inhibitory Properties Against Some Metabolic Enzymes(Wiley, 2025) Demirci, Ozlem; Demir, Yeliz; Gok, Yetkin; Yakali, Gul; Taskin-Tok, Tugba; Muhammed, Muhammed Tilahun; Aktas, AydinHerein, the synthesis of silver(I)-N-heterocyclic carbene (Ag(I)NHC) complexes is presented. These complexes were synthesized from imidazolium salts and silver oxide via the deprotonation method. Ag(I)NHC complexes were characterized using various spectroscopic and analytical techniques, including FTIR, NMR, and elemental analysis. The single crystal structures of the complexes 1e and 1g were illuminated through x-ray crystallography. The study demonstrates that the geometrical characteristics of both complexes closely match those of previously described complexes with a comparable ligand structure. Acetylcholinesterase (AChE) inhibitors prevent the excessive breakdown of acetylcholine by acting on acetylcholinesterase in its neurotransmission. In this way, they help to improve cognitive functions in patients with AD. On the other hand, human carbonic anhydrase inhibitors (CAIs) have been used clinically for many years as antiepileptic, antiglaucoma, antimetastatic, antitumor, and diuretic agents. In this study, the enzyme inhibition abilities of seven imidazol-2-ylidene-silver(I) complexes bearing 4-acetylphenyl side arm were examined against AChE and hCAs. These molecules exhibited a highly potent inhibition effect on AChE and hCAs (Ki values are in the range of 16.27 +/- 1.81 to 130.79 +/- 11.98 nM for AChE, 13.22 +/- 1.88 to 182.14 +/- 33.93 nM for hCA I, and 12.72 +/- 1.99 to 62.36 +/- 9.21 nM for hCA II). Novel imidazol-2-ylidene-silver(I) complexes bearing 4-acetylphenyl side arms 1a-g displayed efficient inhibitory profiles for the examined metabolic enzymes. Docking was additionally performed to investigate the interactions of the current complexes 1a-g with hCA I, hCA II, and AChE proteins. It has been determined that compound 1d has activity against all the tested proteins, with the most effective interaction observed with hCA I. The pharmacokinetic properties of the three top potent complexes for each target against the related proteins were also examined using the SwissADME and pkCSM web tools. In the meantime, the stabilities of the complexes with the highest binding potential according to the docking study were assessed through molecular dynamics simulation. The AChE-1a complex was found to be the one with relatively high stability. Also, further energy computations were made by using the MD simulation results. The compounds have been estimated to bind strongly with their targets.Öğe Bacterial-Based Molecular Communication: Simulation of a Fixed and Receding Receiver Scenarios in Varied Viscosities and Environmental Conditions(Wiley-V C H Verlag Gmbh, 2025) Duman, Mustafa Ozan; Isik, Ibrahim; Isik, Esme; Er, Mehmet BilalThis study introduces a novel bacterial-based molecular communication (BBMC) model for nanoscale information exchange, harnessing the chemotactic behavior of Escherichia coli (E. coli). A comprehensive 3D simulation framework is developed to analyze the impact of key parameters diffusion coefficient (D), chemoattractant release rate (Q), receiver (RX) speed (u), and initial transmitter-receiver distance (d) on communication performance. Results indicate that lower D values enhance the formation of chemoattractant gradients, leading to improved signal clarity and efficiency. Conversely, higher RX speeds distort these gradients, increasing signal reach time and reducing success rates. Elevated Q values significantly broaden the sensing range and improve reliability, particularly over larger distances, though their effect is diminished at high RX speeds. Notably, success rates drop sharply as d approaches the theoretical sensing threshold, underscoring the critical need for parameter tuning. Experimental results validate these findings and reveal a threshold beyond which bacterial movement becomes random, limiting effective signal transmission. These insights contribute to optimizing BBMC systems for greater efficiency and reliability. Applications include targeted drug delivery, environmental biosensing, and synthetic biology, where precise bacterial signaling is essential. The study also demonstrates simulation as a scalable, cost-efficient alternative to experimental methods, addressing complexity and feasibility in real-world scenarios.Öğe Utilization of a One-Pot Prepared Cobalt Selenide Embedded Carbon Matrix Electrode From ZIF-12 for High-Performance Asymmetric Supercapacitors(Wiley, 2024) Gultekin, Sirin Siyahjani; Bugday, Nesrin; Sahin, Damla; Ocakoglu, Kasim; Gultekin, Burak; Yasar, SedatIt is becoming increasingly important to create novel energy storage devices with excellent cycle stability, high power density and high energy density due to the fast advancement in technology. Rechargeable batteries and electrochemical supercapacitors (SCs) are developed as energy storage devices to meet these energy requirements. In this work, a cobalt selenide embedded in a carbon matrix (Co6.8Se8@C) produced from ZIF-12 via a one-pot method by our group for the first time was used as an asymmetric SC electrode. In this work, a cobalt selenide embedded in a carbon matrix (Co6.8Se8@C) produced from ZIF-12 as a precursor by our group previously has been used as an asymmetric SC electrode. The effects of the structural and morphological properties of this composite material on its electrochemical behaviour and capacitive performance were examined both in a three-electrode system as a single electrode and in an asymmetric SC. The superior electrochemical storage performance with a specific capacitance of 77.06 Fg(-1) at 1 Ag-1 and energy density of 27.09 Wh kg(-1) at a power density of 441.90 W kg(-1) were obtained with high stability and cycle life via the prepared electrode in asymmetric SC device.Öğe Induced Pluripotent Stem Cell-Derived Parathyroid Organoids Resemble Parathyroid Morphology and Function(Wiley, 2024) Senkal-Turhan, Selinay; Bulut-Okumus, Ezgi; Aydin, Muhterem; Turkmen, Nese Basak; Taslidere, Asli; Sahin, Fikrettin; Yilmaz, SahinThe primary role of the parathyroid glands is to maintain calcium homeostasis through the secretion of parathyroid hormone (PTH). The limited proliferative capacity and differentiation of parathyroid cells hinder the generation of cell therapy options. In this study, parathyroid organoids are successfully generated from human-induced pluripotent stem cells (hiPSCs). At the end of the 20 days of differentiation, the parathyroid organoids exhibited distinct parathyroid morphology. Stereomicroscope, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analysis demonstrated the 3D arrangement of the cell layers in which intracellular structures of parathyroid cells resemble human parathyroid cellular morphology. Comprehensive molecular analyses, including RNA sequencing (RNA-Seq) and liquid chromatography/mass spectrometry (LC-MS/MS), confirmed the expression of key parathyroid-related markers. Protein expression of CasR, CxCr4, Gcm2, and PTH are observed in parathyroid organoids. Parathyroid organoids secrete PTH, demonstrate active intercellular calcium signaling, and induce osteogenic differentiation via their secretome. The tissue integration potential of parathyroid organoids is determined by transplantation into parathyroidectomized rats. The organoid transplanted animals showed significant elevations in PTH-related markers (CasR, CxCr4, Foxn1, Gcm2, and PTH). PTH secretion is detected in organoid-transplanted animals. The findings represent a significant advancement in parathyroid organoid culture and may offer a cellular therapy for treating PTH-related diseases, including hypoparathyroidism. iPSC-derived parathyroid organoids express PTH-related markers at the protein and gene levels. The transplantation of parathyroid organoids into parathyroidectomized rats shows their functional activity and tissue integration capability. iPSC-derived parathyroid organoids successfully release PTH both in vitro and in vivo. Parathyroid organoid technology may improve defective parathyroid function and related diseases. imageÖğe COMMANLY MISUSED CONCEPTS IN MEDICINE-2(Nobel Ilac, 2024) Daloglu, Ecem Beyza; Yakinci, CengizEstablishing a Turkish terminology in medicine seems essential for Turkish to be a language of science. By preventing medical terminology confusion, unity of terms in medicine will be easily achieved. The easiest way to understand whether the term used in Turkish medicine is correct or incorrect; is to trace its origins in English and if available in Ottoman Turkish. By using this method, many terminological confusions can be avoided.Öğe Health Effects of Plant-Based Diets in University Life: A Comprehensive Study on the Constipation, Sleep and Obesity(Iranian Scientific Society Medical Entomology, 2025) Toguc, HakanBackground: Plant-based diets have gained popularity due to their nutrient density and potential to reduce chronic disease risk. The aim of the study was to examine the relationship between diet quality and plant-based diets consumed with constipation, sleep duration and obesity in university students. Methods: In this study conducted between September and October 2024, 676 students were recruited as participants and data on socio-demographic information, daily sleep duration, presence of constipation, 24-hour food consumption record and food consumption frequency were collected. Diet Quality Index (DQI) and Plant-Based Diet Index (PBDI) were calculated from food consumption record and frequency data. Results: Constipation was present in 14.5% of the participants and the BMI of the participants was 21.84 +/- 3.47 kg/m(2). There was a significant relationship between age and constipation (P=0.013) and a weak negative relationship between age and sleep duration and PBDI (r=-0.103, P=0.007; r=-0.077, P=0.045, respectively); A weak negative correlation was found between BMI and PBDI and DQI (r=-0.092, P=0.016; r=0.173, P=0.000, respectively); a significant correlation was found between the presence of constipation and gender and income level (P=0.047; P=0.013, respectively). Conclusion: PBDI and DQI were associated with lower BMI and emphasised the potential of alternative nutritional models in the fight against obesity. The lack of an association between PBDI, DQI and sleep duration and constipation suggests that further research is needed. This study emphasises the importance of healthy eating and lifestyle interventions, but its design limits causal conclusions and requires further research.Öğe Surface-Engineered TiO2 Film for Enhanced Electrochemical Biosensing and Cell Monitoring(Wiley-V C H Verlag Gmbh, 2026) Sanli, Serdar; Tabak, Eray; Kilinc, Necmettin; Kosemen, Arif; Erginer, Merve; Ozturk, Sadullah; Barlas, Firat BarisIn vitro cell density measuring studies are mostly based on colorimetric methods; however, these approaches are limited to endpoint measurements rather than continuous data. To obtain more sensitive and continuous data, real-time monitoring of cell density is essential, which requires the development of surfaces with optimal physicochemical properties. TiO2 nanoporous structures are promising due to their favorable electrical properties, simple synthesis, unique porosity, biocompatibility, and stability. This study examined TiO2 films deposited onto titanium plates and screen-printed electrodes, characterized by scanning electron microscopy (SEM) and electrochemical techniques. HeLa and A549 cell proliferation on TiO2 was assessed and compared to polystyrene. Cell adhesion was evaluated via DAPI staining, fluorescence microscopy, and SEM. Electrochemical analyses (CV and EIS) were conducted on TiO2-coated electrodes. Results showed comparable proliferation on TiO2 and polystyrene, with effective adhesion confirmed by SEM. Electrochemical data demonstrated high sensitivity in detecting cellular differences, with detection limits of 150 cells for A549 and 107 for HeLa. These findings highlight TiO2 nanoporous structures as promising candidates for cell-based biosensor platforms.Öğe Copper-Induced Phase Transitions in NaMn1-xCuxO2: Structural Insights from Operando XAS, DFT Calculations, and Electrochemical Evaluation Using Laurus Nobilis-Derived Hard Carbon(Wiley-V C H Verlag Gmbh, 2026) Whba, Rawdah; Dogan, Ebru; Harfouche, Messaoud; Ozturk, Zeynep Reyhan; Farhan, Ahlam; Ipek, Semran; Corut, SumeyyeThis study investigates the effect of Cu2+ doping on NaMn1- xCuxO2 layered cathodes. It also explores their integration with Laurus nobilis-derived hard carbon (HC) anodes for sodium-ion batteries (SIBs). Cu doping, particularly at x = 0.20, stabilizes the beta-NaMnO2 phase, suppresses Jahn-Teller distortions, and improves the structural stability of the MnO2 framework. In situ X-ray absorption spectroscopy (XAS) and density functional theory (DFT) calculations confirm that Cu improved Na+ diffusion kinetics and reduces charge-transfer resistance, despite its electrochemical inactivity. X-ray Difraction (XRD), Raman, and Fourier transform infrared spectroscopy (FTIR) analyses reveal phase destabilization and segregation at higher Cu concentrations, while XPS indicates shifts in the Mn/Cu oxidation states, consistent with improved electronic conductivity and multivalent redox behavior. The scanning electron microscope (SEM and transmission electron microscopy (TEM) images demonstrate Cu-induced morphological transitions toward denser, more crystalline structures. Brunauer-Emmett-Teller (BET) measurements reveal that the L. nobilis-derived hard carbon (HC) anode possesses a high surface area and hierarchical porosity, which facilitated efficient Na + storage and rapid ion transport. Full-cell tests demonstrate high reversible capacity (approximate to 126 mAh g-1), excellent rate capability, and 56% capacity retention over 250 cycles. This work demonstrates that Cu doping and porous HC anodes synergistically enhance the structural and electrochemical performance of SIBs, thereby providing a sustainable strategy for advanced energy storage.Öğe Development of Near Infrared Light and Electrically Responsive Shape Memory Polymer Composites Based on Copolyester Thermoplastic Elastomer/Polycaprolactone Blend and Carbon Nanotubes(Wiley, 2025) Tekay, Emre; Aslan, Vahap Uygar; Orhun, Tuana; Sen, Sinan; Aybakan, BetulCarbon nanotubes (CNTs) are carbon-based materials that not only exhibit excellent electrical and thermal conductivity but also possess the ability to absorb light, thereby providing a photothermal effect. Due to these characteristics, when utilized in conjunction with a thermally sensitive shape memory polymer (SMP) matrix, a multi-stimuli responsive shape memory effect (SME) can be achieved. In this study, a thermally responsive SMP blend composed of a copolyester thermoplastic elastomer (COPE) and polycaprolactone (PCL) was transformed into electroactive and light-responsive shape memory polymer composites by incorporating multi-walled carbon nanotubes (MWCNTs) at loadings of 3, 5, 10, and 20 phr. The composite containing 20 phr CNT achieved an electrical resistance of 2.03 Omega cm. Under a voltage of 4 V, the same composite performed Joule heating, resulting in an electroactive shape recovery of 95.67%. It was observed that the light-responsive shape memory effect is more advantageous at lower filler loadings. The composite with 3 phr filler achieved complete shape recovery under NIR light with a wavelength of 808 nm and an intensity of 108 mW/cm(2). The produced composites exhibit multifunctional properties, making them promising candidates for advanced applications including sensors, actuators, responsive smart textiles, and innovative 4D printing technologies.Öğe Effect of Earthquake-Related Trauma on Pubertal Maturation: Evidence From Skeletal Age Assessment Following the 2023 Kahramanmaras Earthquakes(Wiley, 2025) Kavasoglu, Nursezen; Bor, Sabahattin; Zortuk, Fundagul Bilgic; Hamamci, NihalThe devastating earthquakes centered in Kahramanmaras on February 6, 2023, caused significant psychosocial stress among children, which may have influenced the timing of pubertal onset. Since early puberty is associated with adverse physical and psychological outcomes, understanding the potential of environmental factors-such as natural disasters-to accelerate pubertal development is of great importance. In this retrospective study, a total of 1044 wrist radiographs taken from children aged 10-19 at four university dental faculties were evaluated. The radiographs were obtained during two time periods: pre-earthquake (February 6, 2022-February 6, 2023; n = 544) and postearthquake (February 6, 2023-February 6, 2024; n = 500). All images were assessed by a single expert using the skeletal maturation scale proposed by Grave and Brown. The MP3cap stage, which represents the peak of pubertal growth, was used as the main parameter. Due to the distribution of the data, nonparametric statistical tests were applied. In both female and male children, the age at the MP3cap stage after the earthquake was significantly lower compared to pre-earthquake values, indicating earlier pubertal growth spurts (p < 0.05). The findings indicate that the psychosocial stress induced by the Kahramanmara & scedil; earthquakes may have accelerated pubertal development in children. These results underscore the importance of closely monitoring the growth and development of children affected by natural disasters and providing them with comprehensive psychosocial and medical support.Öğe ApoE3 Christchurch and tau interaction as a protective mechanism against Alzheimer's disease(Wiley, 2025) Perez-Corredor, Paula; Arevalo-Alquichire, Said; Mazzarino, Randall; O'Hare, Michael; Muriel-Torres, Andres; Vacano, Guido; Vanderleest, TimothyINTRODUCTION: We described a protected case with familial Alzheimer's disease, homozygous for apolipoprotein E3 (APOE3) Christchurch variant (ApoE3Ch), exhibiting low tau protein levels despite genetic predisposition to the disease due to presenilin (PSEN)1-E280A. We reported the loss of interaction between ApoE3Ch and heparan sulfate proteoglycans (HSPGs) as a critical protective pathway. Here, we characterized differential interacting partners for both wild-type and Christchurch variants to identify additional protective mechanisms of ApoE3Ch. METHODS: We performed pull-down of mouse brain lysates using His-tag-ApoE3 recombinant proteins and determined interacting partners of ApoE3 via mass-spectrometry. We then performed in vitro and in vivo assays to validate the top interactors. RESULTS: We found enhanced binding of ApoE3Ch to tau and Dickkopf-1 (Dkk1, a WNT/beta-catenin antagonist) that resulted in reduced tau aggregation in vitro. We demonstrated that ApoE3Ch interacts directly with Dkk1 and tau, reducing tau pathology. These findings supported the hypothesis of novel protective effects of direct ApoE3Ch interactions.
